RT Journal Article
T1 Blood pressure and risk of cancer in the European Prospective Investigation into Cancer and Nutrition.
A1 Christakoudi, Sofia
A1 Kakourou, Artemisia
A1 Markozannes, Georgios
A1 Tzoulaki, Ioanna
A1 Weiderpass, Elisabete
A1 Brennan, Paul
A1 Gunter, Marc
A1 Dahm, Christina C
A1 Overvad, Kim
A1 Olsen, Anja
A1 Tjønneland, Anne
A1 Boutron-Ruault, Marie-Christine
A1 Madika, Anne-Laure
A1 Severi, Gianluca
A1 Katzke, Verena
A1 Kühn, Tilman
A1 Bergmann, Manuela M
A1 Boeing, Heiner
A1 Karakatsani, Anna
A1 Martimianaki, Georgia
A1 Thriskos, Paschalis
A1 Masala, Giovanna
A1 Sieri, Sabina
A1 Panico, Salvatore
A1 Tumino, Rosario
A1 Ricceri, Fulvio
A1 Agudo, Antonio
A1 Redondo-Sanchez, Daniel
A1 Colorado-Yohar, Sandra M
A1 Mokoroa, Olatz
A1 Melander, Olle
A1 Stocks, Tanja
A1 Häggström, Christel
A1 Harlid, Sophia
A1 Bueno-de-Mesquita, Bas
A1 van Gils, Carla H
A1 Vermeulen, Roel C H
A1 Khaw, Kay-Tee
A1 Wareham, Nicholas J
A1 Tong, Tammy Y N
A1 Freisling, Heinz
A1 Johansson, Mattias
A1 Lennon, Hannah
A1 Aune, Dagfinn
A1 Riboli, Elio
A1 Trichopoulos, Dimitrios
A1 Trichopoulou, Antonia
A1 Tsilidis, Konstantinos K
K1 Europe
K1 association
K1 cancer
K1 cohort
K1 epidemiology
K1 hypertension
K1 morphology
K1 risk factors
AB Several studies have reported associations of hypertension with cancer, but not all results were conclusive. We examined the association of systolic (SBP) and diastolic (DBP) blood pressure with the development of incident cancer at all anatomical sites in the European Prospective Investigation into Cancer and Nutrition (EPIC). Hazard ratios (HRs) (95% confidence intervals) were estimated using multivariable Cox proportional hazards models, stratified by EPIC-participating center and age at recruitment, and adjusted for sex, education, smoking, body mass index, physical activity, diabetes and dietary (in women also reproductive) factors. The study included 307,318 men and women, with an average follow-up of 13.7 (standard deviation 4.4) years and 39,298 incident cancers. We confirmed the expected positive association with renal cell carcinoma: HR = 1.12 (1.08-1.17) per 10 mm Hg higher SBP and HR = 1.23 (1.14-1.32) for DBP. We additionally found positive associations for esophageal squamous cell carcinoma (SCC): HR = 1.16 (1.07-1.26) (SBP), HR = 1.31 (1.13-1.51) (DBP), weaker for head and neck cancers: HR = 1.08 (1.04-1.12) (SBP), HR = 1.09 (1.01-1.17) (DBP) and, similarly, for skin SCC, colon cancer, postmenopausal breast cancer and uterine adenocarcinoma (AC), but not for esophageal AC, lung SCC, lung AC or uterine endometroid cancer. We observed weak inverse associations of SBP with cervical SCC: HR = 0.91 (0.82-1.00) and lymphomas: HR = 0.97 (0.93-1.00). There were no consistent associations with cancers in other locations. Our results are largely compatible with published studies and support weak associations of blood pressure with cancers in specific locations and morphologies.
PB John Wiley & Sons, Inc.
YR 2019
FD 2019-07-14
LK http://hdl.handle.net/10668/14253
UL http://hdl.handle.net/10668/14253
LA en
NO Christakoudi S, Kakourou A, Markozannes G, Tzoulaki I, Weiderpass E, Brennan P, et al. Blood pressure and risk of cancer in the European Prospective Investigation into Cancer and Nutrition. Int J Cancer. 2020 May 15;146(10):2680-2693.
DS RISalud
RD Apr 11, 2025