RT Journal Article T1 Changes in the Epidemiology of Diabetic Retinopathy in Spain: A Systematic Review and Meta-Analysis. A1 Romero-Aroca, Pedro A1 López-Galvez, Maribel A1 Martinez-Brocca, Maria Asuncion A1 Pareja-Ríos, Alicia A1 Artola, Sara A1 Franch-Nadal, Josep A1 Fernandez-Ballart, Joan A1 Andonegui, José A1 Baget-Bernaldiz, Marc K1 diabetes mellitus K1 diabetic retinopathy incidence K1 diabetic retinopathy prevalence K1 epidemiology K1 meta-analysis K1 screening K1 systematic review AB The aim of the present study was to determine the prevalence and incidence of diabetic retinopathy (DR) and its changes in the last 20 years in type 2 diabetes mellitus (T2DM) patients in Spain. A systematic review with a meta-analysis was carried out on the studies published between 2001-2020 on the prevalence and incidence of DR and sight-threatening diabetic retinopathy (STDR) in Spain. The articles included were selected from four databases and publications of the Spanish Ministry of Health and Regional Health Care System (RHCS). The meta-analysis to determine heterogeneity and bias between studies was carried out with the MetaXL 4.0. Since 2001, we have observed an increase in the detection of patients with DM, and at the same time, screening programs for RD have been launched; thus, we can deduce that the increase in the detection of patients with DM, many of them in the initial phases, far exceeds the increased detection of patients with DR. The prevalence of DR was higher between 2001 and 2008 with values of 28.85%. These values decreased over the following period between 2009 and 2020 with a mean of 15.28%. Similarly the STDR prevalence decrease from 3.67% to 1.92% after 2008. The analysis of the longitudinal studies determined that the annual DR incidence was 3.83%, and the STDR annual incidence was 0.41%. In Spain, for T2DM, the current prevalence of DR is 15.28% and 1.92% forSTDR. The annual incidence of DR is 3.83% and is 0.41% for STDR. SN 2227-9032 YR 2022 FD 2022-07-16 LK http://hdl.handle.net/10668/20998 UL http://hdl.handle.net/10668/20998 LA en DS RISalud RD Apr 7, 2025