TY  - JOUR
AU  - Martí, Juan Manuel
AU  - Garcia-Diaz, Angel
AU  - Delgado-Bellido, Daniel
AU  - O'Valle, Francisco
AU  - González-Flores, Ariannys
AU  - Carlevaris, Onintza
AU  - Rodríguez-Vargas, José Manuel
AU  - Amé, Jean Christophe
AU  - Dantzer, Françoise
AU  - King, George L.
AU  - Dziedzic, Klaudia
AU  - Berra, Edurne
AU  - de Álava, E.
AU  - Amaral, A. T.
AU  - Hammond, Ester M.
AU  - Oliver, F. Javier
PY  - 2021
DO  - 10.1016/j.redox.2021.101885
UR  - http://hdl.handle.net/10668/4345
T2  - Redox Biology
AB  - Background: The adaptation to hypoxia is mainly controlled by the HIF transcription factors. Increased expres sion/activity of HIF-1α correlates with poor prognosis in cancer patients. PARP-1 inhibitors are used in the clinic to treat BRCAness...
LA  - en
PB  - Elsevier
KW  - Hypoxia
KW  - PARP-1
KW  - PARylation
KW  - ChIP-seq
KW  - Tumor microenvironment
KW  - Hipoxia
KW  - Inhibidores de poli(ADP-Ribosa) polimerasas
KW  - Poli ADP ribosilación
KW  - Secuenciación de inmunoprecipitación de cromatina
KW  - Microambiente tumoral
KW  - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Respiration::Cell Hypoxia
KW  - Medical Subject Headings::Anatomy::Cells::Cellular Structures::Intracellular Space::Cell Nucleus::Cell Nucleus Structures::Intranuclear Space::Chromosomes::Chromosome Structures::Chromatin
KW  - Medical Subject Headings::Check Tags::Female
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Breast Neoplasms
KW  - Poly(ADP-ribose) Polymerase Inhibitors
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Vesicular Transport Proteins::Coat Protein Complex I::ADP-Ribosylation Factor 1
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Transcription Factors
KW  - Medical Subject Headings::Diseases::Neoplasms::Neoplasms by Site::Endocrine Gland Neoplasms::Ovarian Neoplasms
KW  - Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Purines::Purine Nucleotides::Adenine Nucleotides::Adenosine Diphosphate::Adenosine Diphosphate Sugars
TI  - Selective modulation by PARP-1 of HIF-1α-recruitment to chromatin during hypoxia is required for tumor adaptation to hypoxic conditions
TY  - research article
ER  -