RT Journal Article
T1 Role of the satiety factor oleoylethanolamide in alcoholism.
A1 Bilbao, Ainhoa
A1 Serrano, Antonia
A1 Cippitelli, Andrea
A1 Pavon, Francisco J
A1 Giuffrida, Andrea
A1 Suarez, Juan
A1 Garcia-Marchena, Nuria
A1 Baixeras, Elena
A1 Gomez de Heras, Raquel
A1 Orio, Laura
A1 Alen, Francisco
A1 Ciccocioppo, Roberto
A1 Cravatt, Benjamin F
A1 Parsons, Loren H
A1 Piomelli, Daniele
A1 Rodriguez de Fonseca, Fernando
K1 Alcohol self-administration
K1 PPAR-α
K1 Alcoholism
K1 Oleoylethanolamide
K1 Relapse
AB Oleoylethanolamide (OEA) is a satiety factor that controls motivational responses to dietary fat. Here we show that alcohol administration causes the release of OEA in rodents, which in turn reduces alcohol consumption by engaging peroxisome proliferator-activated receptor-alpha (PPAR-α). This effect appears to rely on peripheral signaling mechanisms as alcohol self-administration is unaltered by intracerebral PPAR-α agonist administration, and the lesion of sensory afferent fibers (by capsaicin) abrogates the effect of systemically administered OEA on alcohol intake. Additionally, OEA is shown to block cue-induced reinstatement of alcohol-seeking behavior (an animal model of relapse) and reduce the severity of somatic withdrawal symptoms in alcohol-dependent animals. Collectively, these findings demonstrate a homeostatic role for OEA signaling in the behavioral effects of alcohol exposure and highlight OEA as a novel therapeutic target for alcohol use disorders and alcoholism.
PB Wiley-Blackwell Publishing Ltd.
YR 2015
FD 2015-06-02
LK http://hdl.handle.net/10668/9861
UL http://hdl.handle.net/10668/9861
LA en
NO Bilbao A, Serrano A, Cippitelli A, Pavón FJ, Giuffrida A, Suárez J, et al. Role of the satiety factor oleoylethanolamide in alcoholism. Addict Biol. 2016 Jul;21(4):859-72.
DS RISalud
RD Apr 6, 2025