RT Journal Article
T1 Late presentation of chronic HBV and HCV patients seeking first time specialist care in Spain: a 2-year registry review
A1 Picchio, Camila A.
A1 Lens, Sabela
A1 Hernandez-Guerra, Manuel
A1 Arenas, Juan
A1 Andrade, Raúl J.
A1 Crespo, Javier
A1 García-Samaniego, Javier
A1 Romero-Gómez, Manuel
A1 Turnes, Juan
A1 Calleja, José Luis
A1 Simón, Miguel Ángel
A1 White, Trenton M.
A1 Riveiro-Barciela, Mar
A1 Pocurull, Anna
A1 Morales-Arraez, Dalia
A1 Gómez, Alexandra
A1 Buti, Maria
A1 Lazarus, Jeffrey V.
K1 Hepatitis C, chronic
K1 Hepatitis B, chronic
K1 Liver disease
K1 Referral and consultation
K1 Disease progression
K1 Hepatitis C crónica
K1 Hepatitis B crónica
K1 Enfermedades hepáticas
K1 Derivación y consulta
K1 Progresión de la enfermedad
AB Chronic viral hepatitis infection affects an estimated 325 million people globally. People who initiate treatment after significant disease progression face increased risk of severe liver complications and death. Data are scarce on the characteristics and risk factors of people who present late to care in Spain and globally. Data were collected from January 2018 to December 2019 to report late presentation (LP) to specialist care at 11 large university hospitals in Spain to assess related risk factors using a multivariable logistic regression model. 2290 (CHB = 505, CHC = 1785) patients were analysed, with 581 (25.2%) presenting late. Hepatitis C patients more frequently reported LP compared to hepatitis B patients (28.1% vs 15.0%; p < 0.001). Older age (p < 0.001), being male (p < 0.001), being Spanish-born (p < 0.001), and having an unknown origin of referral (p = 0.08) were associated with a higher likelihood of LP. Advanced liver disease was identified in 533 (23%) patients and late-stage liver disease in 124 (5.4%). LP, including with irreversible liver damage, to viral hepatitis specialist care is frequent in Spain, despite being a country with unrestricted treatment access. Initiatives to reduce LP should specifically target men, older individuals, foreign-born populations for CHB, and Spanish nationals for CHC.
PB Springer Nature
YR 2021
FD 2021-12-17
LK http://hdl.handle.net/10668/4573
UL http://hdl.handle.net/10668/4573
LA en
NO Picchio CA, Lens S, Hernandez-Guerra M, Arenas J, Andrade RJ, Crespo J, et al. Late presentation of chronic HBV and HCV patients seeking first time specialist care in Spain: a 2-year registry review. Sci Rep. 2021 Dec 17;11(1):24133
DS RISalud
RD Apr 8, 2025