The genetic architecture of the human cerebral cortex.

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dc.contributor.authorGrasby, Katrina L
dc.contributor.authorJahanshad, Neda
dc.contributor.authorPainter, Jodie N
dc.contributor.authorColodro-Conde, Lucía
dc.contributor.authorBralten, Janita
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dc.contributor.authorde Zwarte, Sonja M C
dc.contributor.authorden Braber, Anouk
dc.contributor.authorDoan, Nhat Trung
dc.contributor.authorDohm, Katharina
dc.contributor.authorEhrlich, Stefan
dc.contributor.authorEngelbrecht, Hannah-Ruth
dc.contributor.authorErk, Susanne
dc.contributor.authorFan, Chun Chieh
dc.contributor.authorFedko, Iryna O
dc.contributor.authorFoley, Sonya F
dc.contributor.authorFord, Judith M
dc.contributor.authorFukunaga, Masaki
dc.contributor.authorGarrett, Melanie E
dc.contributor.authorGe, Tian
dc.contributor.authorGiddaluru, Sudheer
dc.contributor.authorGoldman, Aaron L
dc.contributor.authorGreen, Melissa J
dc.contributor.authorGroenewold, Nynke A
dc.contributor.authorGrotegerd, Dominik
dc.contributor.authorGurholt, Tiril P
dc.contributor.authorGutman, Boris A
dc.contributor.authorHansell, Narelle K
dc.contributor.authorHarris, Mathew A
dc.contributor.authorHarrison, Marc B
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dc.contributor.authorHauser, Michael
dc.contributor.authorHerms, Stefan
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dc.contributor.authorHo, New Fei
dc.contributor.authorHoehn, David
dc.contributor.authorHoffmann, Per
dc.contributor.authorHolleran, Laurena
dc.contributor.authorHoogman, Martine
dc.contributor.authorHottenga, Jouke-Jan
dc.contributor.authorIkeda, Masashi
dc.contributor.authorJanowitz, Deborah
dc.contributor.authorJansen, Iris E
dc.contributor.authorJia, Tianye
dc.contributor.authorJockwitz, Christiane
dc.contributor.authorKanai, Ryota
dc.contributor.authorKarama, Sherif
dc.contributor.authorKasperaviciute, Dalia
dc.contributor.authorKaufmann, Tobias
dc.contributor.authorKelly, Sinead
dc.contributor.authorKikuchi, Masataka
dc.contributor.authorKlein, Marieke
dc.contributor.authorKnapp, Michael
dc.contributor.authorKnodt, Annchen R
dc.contributor.authorKrämer, Bernd
dc.contributor.authorLam, Max
dc.contributor.authorLancaster, Thomas M
dc.contributor.authorLee, Phil H
dc.contributor.authorLett, Tristram A
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dc.contributor.authorLopes-Cendes, Iscia
dc.contributor.authorLuciano, Michelle
dc.contributor.authorMacciardi, Fabio
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dc.contributor.authorMota, Nina Roth
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dc.contributor.authorSchlag, Fenja
dc.contributor.authorSchmaal, Lianne
dc.contributor.authorSchofield, Peter R
dc.contributor.authorSecolin, Rodrigo
dc.contributor.authorShapland, Chin Yang
dc.contributor.authorShen, Li
dc.contributor.authorShin, Jean
dc.contributor.authorShumskaya, Elena
dc.contributor.authorSønderby, Ida E
dc.contributor.authorSprooten, Emma
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dc.contributor.authorThalamuthu, Anbupalam
dc.contributor.authorTordesillas-Gutiérrez, Diana
dc.contributor.authorTurner, Jessica A
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dc.contributor.authorVallerga, Costanza Ludovica
dc.contributor.authorvan der Meer, Dennis
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dc.contributor.authorWalton, Esther
dc.contributor.authorWang, Mingyuan
dc.contributor.authorWang, Yunpeng
dc.contributor.authorWardlaw, Joanna M
dc.contributor.authorWen, Wei
dc.contributor.authorWestlye, Lars T
dc.contributor.authorWhelan, Christopher D
dc.contributor.authorWitt, Stephanie H
dc.contributor.authorWittfeld, Katharina
dc.contributor.authorWolf, Christiane
dc.contributor.authorWolfers, Thomas
dc.contributor.authorWu, Jing Qin
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dc.contributor.authorZhang, Zuo
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dc.contributor.authorBelger, Aysenil
dc.contributor.authorBrandt, Christine L
dc.contributor.authorBrown, Gregory G
dc.contributor.authorCichon, Sven
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dc.contributor.authorDennis, Michelle F
dc.contributor.authorDietsche, Bruno
dc.contributor.authorDjurovic, Srdjan
dc.contributor.authorDoherty, Colin P
dc.contributor.authorEspiritu, Ryan
dc.contributor.authorGarijo, Daniel
dc.contributor.authorGil, Yolanda
dc.contributor.authorGowland, Penny A
dc.contributor.authorGreen, Robert C
dc.contributor.authorHäusler, Alexander N
dc.contributor.authorHeindel, Walter
dc.contributor.authorHo, Beng-Choon
dc.contributor.authorHoffmann, Wolfgang U
dc.contributor.authorHolsboer, Florian
dc.contributor.authorHomuth, Georg
dc.contributor.authorHosten, Norbert
dc.contributor.authorJack, Clifford R
dc.contributor.authorJang, MiHyun
dc.contributor.authorJansen, Andreas
dc.contributor.authorKimbrel, Nathan A
dc.contributor.authorKolskår, Knut
dc.contributor.authorKoops, Sanne
dc.contributor.authorKrug, Axel
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dc.contributor.authorLuykx, Jurjen J
dc.contributor.authorMathalon, Daniel H
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dc.contributor.authorMayoral Van Son, Jaqueline
dc.contributor.authorMcEwen, Sarah C
dc.contributor.authorMelle, Ingrid
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dc.contributor.authorMueller, Bryon A
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dc.contributor.authorMartinot, Marie-Laure Paillère
dc.contributor.authorPike, G Bruce
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dc.contributor.authorQuinlan, Erin B
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dc.contributor.authorRatnakar, Varun
dc.contributor.authorReppermund, Simone
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dc.contributor.authorWhelan, Robert
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dc.contributor.authorYamamori, Hidenaga
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dc.contributor.authorDecarli, Charles
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dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorHofer, Edith
dc.contributor.authorIkram, M Arfan
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dc.contributor.authorYang, Qiong
dc.contributor.authorAlzheimer’s Disease Neuroimaging Initiative
dc.contributor.authorCHARGE Consortium
dc.contributor.authorEPIGEN Consortium
dc.contributor.authorIMAGEN Consortium
dc.contributor.authorSYS Consortium
dc.contributor.authorParkinson’s Progression Markers Initiative
dc.contributor.authorAlvim, Marina K M
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dc.contributor.authorHeinz, Andreas
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dc.contributor.authorHoekstra, Pieter J
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dc.contributor.authorHulshoff Pol, Hilleke E
dc.contributor.authorJernigan, Terry L
dc.contributor.authorJönsson, Erik G
dc.contributor.authorKahn, René S
dc.contributor.authorKennedy, Martin A
dc.contributor.authorKircher, Tilo T J
dc.contributor.authorKochunov, Peter
dc.contributor.authorKwok, John B J
dc.contributor.authorLe Hellard, Stephanie
dc.contributor.authorLoughland, Carmel M
dc.contributor.authorMartin, Nicholas G
dc.contributor.authorMartinot, Jean-Luc
dc.contributor.authorMcDonald, Colm
dc.contributor.authorMcMahon, Katie L
dc.contributor.authorMeyer-Lindenberg, Andreas
dc.contributor.authorMichie, Patricia T
dc.contributor.authorMorey, Rajendra A
dc.contributor.authorMowry, Bryan
dc.contributor.authorNyberg, Lars
dc.contributor.authorOosterlaan, Jaap
dc.contributor.authorOphoff, Roel A
dc.contributor.authorPantelis, Christos
dc.contributor.authorPaus, Tomas
dc.contributor.authorPausova, Zdenka
dc.contributor.authorPenninx, Brenda W J H
dc.contributor.authorPolderman, Tinca J C
dc.contributor.authorPosthuma, Danielle
dc.contributor.authorRietschel, Marcella
dc.contributor.authorRoffman, Joshua L
dc.contributor.authorRowland, Laura M
dc.contributor.authorSachdev, Perminder S
dc.contributor.authorSämann, Philipp G
dc.contributor.authorSchall, Ulrich
dc.contributor.authorSchumann, Gunter
dc.contributor.authorScott, Rodney J
dc.contributor.authorSim, Kang
dc.contributor.authorSisodiya, Sanjay M
dc.contributor.authorSmoller, Jordan W
dc.contributor.authorSommer, Iris E
dc.contributor.authorSt Pourcain, Beate
dc.contributor.authorStein, Dan J
dc.contributor.authorToga, Arthur W
dc.contributor.authorTrollor, Julian N
dc.contributor.authorVan der Wee, Nic J A
dc.contributor.authorvan 't Ent, Dennis
dc.contributor.authorVölzke, Henry
dc.contributor.authorWalter, Henrik
dc.contributor.authorWeber, Bernd
dc.contributor.authorWeinberger, Daniel R
dc.contributor.authorWright, Margaret J
dc.contributor.authorZhou, Juan
dc.contributor.authorStein, Jason L
dc.contributor.authorThompson, Paul M
dc.contributor.authorMedland, Sarah E
dc.contributor.authorEnhancing NeuroImaging Genetics through Meta-Analysis Consortium (ENIGMA)—Genetics working group
dc.date.accessioned2025-01-07T16:21:14Z
dc.date.available2025-01-07T16:21:14Z
dc.date.issued2020
dc.description.abstractThe cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder.
dc.identifier.doi10.1126/science.aay6690
dc.identifier.essn1095-9203
dc.identifier.pmcPMC7295264
dc.identifier.pmid32193296
dc.identifier.pubmedURLhttps://pmc.ncbi.nlm.nih.gov/articles/PMC7295264/pdf
dc.identifier.unpaywallURLhttp://www.bristol.ac.uk/alspac/external/documents/grant-acknowledgements.pdf
dc.identifier.urihttps://hdl.handle.net/10668/27761
dc.issue.number6484
dc.journal.titleScience (New York, N.Y.)
dc.journal.titleabbreviationScience
dc.language.isoen
dc.organizationSAS - Hospital Universitario Virgen del Rocío
dc.organizationInstituto de Investigación Biomédica de Sevilla (IBIS)
dc.pubmedtypeJournal Article
dc.pubmedtypeMeta-Analysis
dc.pubmedtypeResearch Support, N.I.H., Extramural
dc.pubmedtypeResearch Support, N.I.H., Intramural
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.pubmedtypeResearch Support, U.S. Gov't, Non-P.H.S.
dc.rights.accessRightsopen access
dc.subject.meshAttention Deficit Disorder with Hyperactivity
dc.subject.meshBrain Mapping
dc.subject.meshCerebral Cortex
dc.subject.meshCognition
dc.subject.meshGenetic Loci
dc.subject.meshGenetic Variation
dc.subject.meshGenome-Wide Association Study
dc.subject.meshHumans
dc.subject.meshMagnetic Resonance Imaging
dc.subject.meshOrgan Size
dc.subject.meshParkinson Disease
dc.titleThe genetic architecture of the human cerebral cortex.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number367

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