Phenotypic characterisation of early COPD: a prospective case-control study.
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2020-10-05
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Cosío, Borja G
Pascual-Guardia, Sergi
Borras-Santos, Alicia
Peces-Barba, Germán
Santos, Salud
Vigil, Laura
Soler-Cataluña, Juan José
Martínez-González, Cristina
Casanova, Ciro
Marcos, Pedro J
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Abstract
The phenotypic characteristics of chronic obstructive pulmonary disease (COPD) in individuals younger than 50 years of age (early COPD) are not well defined. This prospective, multicentre, case-control study sought to describe these characteristics and compare them with those of smokers (≥10 pack-years) of similar age with normal spirometry (controls). We studied 92 cases (post-bronchodilator forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC)