Non-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity

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dc.contributor.authorCardenas, Casimiro
dc.contributor.authorAntonio Torres-Vargas, Jose
dc.contributor.authorCardenas-Valdivia, Abel
dc.contributor.authorJurado, Nuria
dc.contributor.authorQuesada, Ana R.
dc.contributor.authorGarcia-Caballero, Melissa
dc.contributor.authorMartinez-Poveda, Beatriz
dc.contributor.authorAngel Medina, Miguel
dc.contributor.authoraffiliation[Cardenas, Casimiro] Univ Malaga, Andalucia Tech, Fac Ciencias, Dept Biol Mol & Bioquim, E-29071 Malaga, Spain
dc.contributor.authoraffiliation[Antonio Torres-Vargas, Jose] Univ Malaga, Andalucia Tech, Fac Ciencias, Dept Biol Mol & Bioquim, E-29071 Malaga, Spain
dc.contributor.authoraffiliation[Jurado, Nuria] Univ Malaga, Andalucia Tech, Fac Ciencias, Dept Biol Mol & Bioquim, E-29071 Malaga, Spain
dc.contributor.authoraffiliation[Quesada, Ana R.] Univ Malaga, Andalucia Tech, Fac Ciencias, Dept Biol Mol & Bioquim, E-29071 Malaga, Spain
dc.contributor.authoraffiliation[Garcia-Caballero, Melissa] Univ Malaga, Andalucia Tech, Fac Ciencias, Dept Biol Mol & Bioquim, E-29071 Malaga, Spain
dc.contributor.authoraffiliation[Martinez-Poveda, Beatriz] Univ Malaga, Andalucia Tech, Fac Ciencias, Dept Biol Mol & Bioquim, E-29071 Malaga, Spain
dc.contributor.authoraffiliation[Angel Medina, Miguel] Univ Malaga, Andalucia Tech, Fac Ciencias, Dept Biol Mol & Bioquim, E-29071 Malaga, Spain
dc.contributor.authoraffiliation[Cardenas, Casimiro] Univ Malaga, Res Support Cent Serv SCAI, Malaga, Spain
dc.contributor.authoraffiliation[Antonio Torres-Vargas, Jose] IBIMA Biomed Res Inst Malaga, E-29071 Malaga, Spain
dc.contributor.authoraffiliation[Quesada, Ana R.] IBIMA Biomed Res Inst Malaga, E-29071 Malaga, Spain
dc.contributor.authoraffiliation[Garcia-Caballero, Melissa] IBIMA Biomed Res Inst Malaga, E-29071 Malaga, Spain
dc.contributor.authoraffiliation[Martinez-Poveda, Beatriz] IBIMA Biomed Res Inst Malaga, E-29071 Malaga, Spain
dc.contributor.authoraffiliation[Angel Medina, Miguel] IBIMA Biomed Res Inst Malaga, E-29071 Malaga, Spain
dc.contributor.authoraffiliation[Cardenas-Valdivia, Abel] Univ Malaga, Fac Sci, Dept Phys Chem, Malaga, Spain
dc.contributor.authoraffiliation[Quesada, Ana R.] CIBER Enfermedades Raras CIBERER, E-29071 Malaga, Spain
dc.contributor.authoraffiliation[Angel Medina, Miguel] CIBER Enfermedades Raras CIBERER, E-29071 Malaga, Spain
dc.contributor.authoraffiliation[Martinez-Poveda, Beatriz] CIBER Enfermedades Cardiovasc CIBERCV, Madrid, Spain
dc.contributor.funderSpanish Ministry of Science, Innovation and Universities
dc.contributor.funderFEDER
dc.contributor.funderAndalusian Government
dc.date.accessioned2025-01-07T16:01:07Z
dc.date.available2025-01-07T16:01:07Z
dc.date.issued2021-10-06
dc.description.abstractThe tropical plant Annona muricata has been widely used for traditional ethnobotanic and pharmacologic applications. Extracts from different parts of this plant have been shown to have a wide range of biological activities. In the present study, we carry out a metabolomic study of both aqueous and DMSO extracts from Annona muricata leaves that has allowed us to identify 33 bioactive compounds. Furthermore, we have shown that aqueous extracts are able to inhibit endothelial cell migration and both aqueous and DMSO extracts inhibit the formation of tubule-like structures by endothelial cells cultured on Matrigel. We conclude that extracts of Annona muricata leaves have great potential as anti-angiogenic natural combinations of bioactive compounds.
dc.identifier.doi10.1016/j.biopha.2021.112263
dc.identifier.essn1950-6007
dc.identifier.issn0753-3322
dc.identifier.pmid34626933
dc.identifier.unpaywallURLhttps://doi.org/10.1016/j.biopha.2021.112263
dc.identifier.urihttps://hdl.handle.net/10668/27565
dc.identifier.wosID712633500002
dc.journal.titleBiomedicine & pharmacotherapy
dc.journal.titleabbreviationBiomed. pharmacother.
dc.language.isoen
dc.organizationInstituto de Investigación Biomédica de Málaga - Plataforma Bionand (IBIMA)
dc.publisherElsevier france-editions scientifiques medicales elsevier
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectUltra-high-performance liquid
dc.subjectchromatography-high-resolution mass spec-trometry(UHPLC-HRMS)
dc.subjectAnnona muricata
dc.subjectGraviola
dc.subjectSoursop
dc.subjectAngiogenesis
dc.subjectBreast-cancer cells
dc.subjectIn-vitro
dc.subjectRing acetogenins
dc.subjectEthanol extract
dc.subjectL. annonaceae
dc.subjectFruit extract
dc.subjectLeaves
dc.subjectGraviola
dc.subjectAntioxidant
dc.subjectIdentification
dc.titleNon-targeted metabolomics characterization of Annona muricata leaf extracts with anti-angiogenic activity
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number144
dc.wostypeArticle

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