Podocyte and tubular involvement in AngioJet-induced kidney injury.
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2019-08-23
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Esteras, Raquel
Cannata-Ortiz, Pablo
Del Palacio-Tamarit, Marta
Guerrero-Hue, Melania
García-Caballero, Cristina
Egido, Jesús
Gimeno, Javier
Ortiz, Alberto
Gracia-Iguacel, Carolina
Moreno, Juan Antonio
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Abstract
The AngioJet technique combines localized thrombolysis and percutaneous mechanical thrombectomy (PMT). However, PMT may cause acute kidney injury (AKI), which has been ascribed to severe mechanical haemolysis, although no renal biopsies have been reported. We now report the first renal biopsy in a patient with AKI following PMT. There is histological evidence of haemoglobin (Hb)-induced tubular injury and podocyte stress characterized by intracellular Hb and staining for ferritin and hemo-oxygenase-1, suggestive of an adaptive response to oxidative stress. This confirms that Hb is involved in kidney cell injury and supports the existence of several different kidney cellular targets.
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AngioJet, acute kidney injury, haemoglobinuria, mechanical thrombolysis, podocyte, tubular cell