Radiobiological considerations in combining doses from external beam radiotherapy and brachytherapy for cervical cancer.

dc.contributor.authorTornero-López, Ana M
dc.contributor.authorGuirado, Damián
dc.date.accessioned2025-01-07T12:40:23Z
dc.date.available2025-01-07T12:40:23Z
dc.date.issued2018-07-02
dc.description.abstractThe recommended radio-therapeutic treatment for cervix cancer consists of a first phase of external beam radiotherapy (EBRT) plus a second phase of brachytherapy (BT), the combined treatment being delivered within 8 weeks. In order to assess a comprehensive dosimetry of the whole treatment, it is necessary to take into account that these two phases are characterized by different spatial and temporal dosimetric distributions, which complicates the task of the summation of the two contributions, EBRT and BT. Radiobiology allows to tackle this issue pragmatically by means of the LQ model and, in fact, this is the usual tool currently in use for this matter. In this work, we describe the rationale behind the summation of the dosimetric contributions of the two phases of the treatment, EBRT and BT, for cervix cancer, as carried out with the LQ model. Besides, we address, from a radiobiological point of view, several important considerations regarding the use of the LQ model for this task. One of them is the analysis of the effect of the overall treatment time in the result of the global treatment. Another important question considered is related to the fact that the capacity of LQ to predict the treatment outcomes is deteriorated when the dose per fraction of the radiotherapic scheme exceeds 6-10 Gy, which is a typical brachytherapy fractionation. Finally, we analyze the influence of the uncertainty and the variability of the main parameters utilized in the LQ model formulation in the assessment of the global dosimetry.
dc.identifier.doi10.1016/j.rpor.2018.05.007
dc.identifier.issn1507-1367
dc.identifier.pmcPMC6277272
dc.identifier.pmid30534020
dc.identifier.pubmedURLhttps://pmc.ncbi.nlm.nih.gov/articles/PMC6277272/pdf
dc.identifier.unpaywallURLhttps://europepmc.org/articles/pmc6277272?pdf=render
dc.identifier.urihttps://hdl.handle.net/10668/24833
dc.issue.number6
dc.journal.titleReports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology
dc.journal.titleabbreviationRep Pract Oncol Radiother
dc.language.isoen
dc.organizationSAS - Hospital de Poniente
dc.page.number562-573
dc.pubmedtypeJournal Article
dc.pubmedtypeReview
dc.rights.accessRightsopen access
dc.subjectBrachytherapy
dc.subjectCervix cancer
dc.subjectCombined treatment
dc.subjectLQ model
dc.subjectOverall treatment time
dc.subjectRadiobiology
dc.titleRadiobiological considerations in combining doses from external beam radiotherapy and brachytherapy for cervical cancer.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number23

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