Anti-CD137 and PD-1/PD-L1 Antibodies En Route toward Clinical Synergy.
| dc.contributor.author | Pérez-Ruiz, Elisabeth | |
| dc.contributor.author | Etxeberria, Iñaki | |
| dc.contributor.author | Rodriguez-Ruiz, Maria E | |
| dc.contributor.author | Melero, Ignacio | |
| dc.date.accessioned | 2025-01-07T14:53:17Z | |
| dc.date.available | 2025-01-07T14:53:17Z | |
| dc.date.issued | 2017-08-08 | |
| dc.description.abstract | T-cell costimulation and coinhibition can be respectively exploited by blocking and agonist mAbs. Both strategies can be synergistically combined in mouse models. Early clinical results from combinations of anti-PD-1 mAbs in conjunction with agonist anti-CD137 (4-1BB) mAbs show excellent safety and promising efficacy. Clin Cancer Res; 23(18); 5326-8. ©2017 AACRSee related article by Tolcher et al., p. 5349. | |
| dc.identifier.doi | 10.1158/1078-0432.CCR-17-1799 | |
| dc.identifier.essn | 1557-3265 | |
| dc.identifier.pmid | 28790118 | |
| dc.identifier.uri | https://hdl.handle.net/10668/26705 | |
| dc.issue.number | 18 | |
| dc.journal.title | Clinical cancer research : an official journal of the American Association for Cancer Research | |
| dc.journal.titleabbreviation | Clin Cancer Res | |
| dc.language.iso | en | |
| dc.organization | SAS - Hospital Costa del Sol | |
| dc.page.number | 5326-5328 | |
| dc.pubmedtype | Letter | |
| dc.subject.mesh | Antibodies, Monoclonal | |
| dc.subject.mesh | Antineoplastic Agents, Immunological | |
| dc.subject.mesh | Antineoplastic Combined Chemotherapy Protocols | |
| dc.subject.mesh | B7-H1 Antigen | |
| dc.subject.mesh | Clinical Trials, Phase I as Topic | |
| dc.subject.mesh | Drug Synergism | |
| dc.subject.mesh | Humans | |
| dc.subject.mesh | Molecular Targeted Therapy | |
| dc.subject.mesh | Neoplasms | |
| dc.subject.mesh | Programmed Cell Death 1 Receptor | |
| dc.subject.mesh | Treatment Outcome | |
| dc.subject.mesh | Tumor Necrosis Factor Receptor Superfamily, Member 9 | |
| dc.title | Anti-CD137 and PD-1/PD-L1 Antibodies En Route toward Clinical Synergy. | |
| dc.type | research article | |
| dc.volume.number | 23 |