Mortality prediction in chronic obstructive pulmonary disease comparing the GOLD 2015 and GOLD 2019 staging: a pooled analysis of individual patient data.

dc.contributor.authorGarcía Castillo, Elena
dc.contributor.authorAlonso Pérez, Tamara
dc.contributor.authorAncochea, Julio
dc.contributor.authorPastor Sanz, Maria Teresa
dc.contributor.authorAlmagro, Pere
dc.contributor.authorMartínez-Camblor, Pablo
dc.contributor.authorMiravitlles, Marc
dc.contributor.authorRodríguez-Carballeira, Mónica
dc.contributor.authorNavarro, Annie
dc.contributor.authorLamprecht, Bernd
dc.contributor.authorRamírez-García Luna, Ana S
dc.contributor.authorKaiser, Bernhard
dc.contributor.authorAlfageme, Inmaculada
dc.contributor.authorCasanova, Ciro
dc.contributor.authorEsteban, Cristóbal
dc.contributor.authorSoler-Cataluña, Juan J
dc.contributor.authorde-Torres, Juan P
dc.contributor.authorCelli, Bartolomé R
dc.contributor.authorMarín, Jose M
dc.contributor.authorTer Riet, Gerben
dc.contributor.authorSobradillo, Patricia
dc.contributor.authorLange, Peter
dc.contributor.authorGarcia-Aymerich, Judith
dc.contributor.authorAnto, Josep M
dc.contributor.authorTurner, Alice M
dc.contributor.authorHan, MeiLan K
dc.contributor.authorLanghammer, Arnulf
dc.contributor.authorVikjord, Sigrid Anna Aalberg
dc.contributor.authorSternberg, Alice
dc.contributor.authorLeivseth, Linda
dc.contributor.authorBakke, Per
dc.contributor.authorJohannessen, Ane
dc.contributor.authorOga, Toru
dc.contributor.authorCosío, Borja G
dc.contributor.authorEchazarreta, Andrés
dc.contributor.authorRoche, Nicolás
dc.contributor.authorBurgel, Pierre-Régis
dc.contributor.authorSin, Don D
dc.contributor.authorPuhan, Milo A
dc.contributor.authorLópez-Campos, Jose Luis
dc.contributor.authorCarrasco, Laura
dc.contributor.authorSoriano, Joan B
dc.date.accessioned2025-01-07T16:34:45Z
dc.date.available2025-01-07T16:34:45Z
dc.date.issued2020-11-02
dc.description.abstractIn 2019, The Global Initiative for Chronic Obstructive Lung Disease (GOLD) modified the grading system for patients with COPD, creating 16 subgroups (1A-4D). As part of the COPD Cohorts Collaborative International Assessment (3CIA) initiative, we aim to compare the mortality prediction of the 2015 and 2019 COPD GOLD staging systems. We studied 17 139 COPD patients from the 3CIA study, selecting those with complete data. Patients were classified by the 2015 and 2019 GOLD ABCD systems, and we compared the predictive ability for 5-year mortality of both classifications. In total, 17 139 patients with COPD were enrolled in 22 cohorts from 11 countries between 2003 and 2017; 8823 of them had complete data and were analysed. Mean±sd age was 63.9±9.8 years and 62.9% were male. GOLD 2019 classified the patients in milder degrees of COPD. For both classifications, group D had higher mortality. 5-year mortality did not differ between groups B and C in GOLD 2015; in GOLD 2019, mortality was greater for group B than C. Patients classified as group A and B had better sensitivity and positive predictive value with the GOLD 2019 classification than GOLD 2015. GOLD 2015 had better sensitivity for group C and D than GOLD 2019. The area under the curve values for 5-year mortality were only 0.67 (95% CI 0.66-0.68) for GOLD 2015 and 0.65 (95% CI 0.63-0.66) for GOLD 2019. The new GOLD 2019 classification does not predict mortality better than the previous GOLD 2015 system.
dc.identifier.doi10.1183/23120541.00253-2020
dc.identifier.issn2312-0541
dc.identifier.pmcPMC7682666
dc.identifier.pmid33263033
dc.identifier.pubmedURLhttps://pmc.ncbi.nlm.nih.gov/articles/PMC7682666/pdf
dc.identifier.unpaywallURLhttps://openres.ersjournals.com/content/erjor/6/4/00253-2020.full.pdf
dc.identifier.urihttps://hdl.handle.net/10668/27872
dc.issue.number4
dc.journal.titleERJ open research
dc.journal.titleabbreviationERJ Open Res
dc.language.isoen
dc.organizationInstituto de Investigación Biomédica de Sevilla (IBIS)
dc.organizationSAS - Hospital Universitario Virgen del Rocío
dc.organizationInstituto de Investigación Biomédica de Sevilla (IBIS)
dc.pubmedtypeJournal Article
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.titleMortality prediction in chronic obstructive pulmonary disease comparing the GOLD 2015 and GOLD 2019 staging: a pooled analysis of individual patient data.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number6

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