Control of hyperparathyroidism with the intravenous calcimimetic etelcalcetide in dialysis patients adherent and non-adherent to oral calcimimetics.

dc.contributor.authorArenas, Maria Dolores
dc.contributor.authorRodelo-Haad, Cristian
dc.contributor.authorde Mier, M Victoria Pendón-Ruiz
dc.contributor.authorRodriguez, Mariano
dc.date.accessioned2025-01-07T13:45:01Z
dc.date.available2025-01-07T13:45:01Z
dc.date.issued2020-02-12
dc.description.abstractIn dialysis patients, non-adherence to oral cinacalcet adds complexity to the control of secondary hyperparathyroidism. The present study aims to evaluate the use of intravenous calcimimetic, etelcalcetide, in the control of secondary hyperparathyroidism in patients adherent and non-adherent to oral calcimimetics. The Simplified Medication Adherence Questionnaire was used to identify non-adherence. Almost half of the patients were non-adherent to the treatment with cinacalcet. Twenty-five patients (15 non-adherent) were switched from cinacalcet to etelcalcetide and were followed-up monthly for 8 months. Cinacalcet was discontinued for 1 week before the initiation of etelcalcetide. After this period, the serum PTH levels increased by2-fold in adherent patients, whereas it did not change in non-adherent patients suggesting that they were not taking the medication. Etelcalcetide progressively reduced serum parathyroid hormone (PTH) (mean ± standard deviation) from 818 ± 395 to 367 ± 289 pg/mL (P  The lack of adherence to cinacalcet is a possible cause of the apparent lack of response to oral calcimimetic. The use of etelcalcetide ensures compliance and control of secondary hyperparathyroidism in both non-adherent and adherent patients.
dc.identifier.doi10.1093/ckj/sfaa005
dc.identifier.issn2048-8505
dc.identifier.pmcPMC7986320
dc.identifier.pmid33777366
dc.identifier.pubmedURLhttps://pmc.ncbi.nlm.nih.gov/articles/PMC7986320/pdf
dc.identifier.unpaywallURLhttps://academic.oup.com/ckj/article-pdf/14/3/840/36670563/sfaa005.pdf
dc.identifier.urihttps://hdl.handle.net/10668/25825
dc.issue.number3
dc.journal.titleClinical kidney journal
dc.journal.titleabbreviationClin Kidney J
dc.language.isoen
dc.organizationSAS - Hospital Universitario Reina Sofía
dc.organizationSAS - Hospital Universitario Reina Sofía
dc.organizationInstituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC)
dc.page.number840-846
dc.pubmedtypeJournal Article
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.subjectPTH
dc.subjectadherence
dc.subjectcalcium
dc.subjectcinacalcet
dc.subjectetelcalcetide
dc.titleControl of hyperparathyroidism with the intravenous calcimimetic etelcalcetide in dialysis patients adherent and non-adherent to oral calcimimetics.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number14

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