Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson's disease

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dc.contributor.authorMartinez-Horta, Saul
dc.contributor.authorBejr-Kasem, Helena
dc.contributor.authorHorta-Barba, Andrea
dc.contributor.authorPascual-Sedano, Berta
dc.contributor.authorSantos-Garcia, Diego
dc.contributor.authorDe Deus-Fonticoba, Teresa
dc.contributor.authorJesus, Silvia
dc.contributor.authorAguilar, Miquel
dc.contributor.authorPlanellas, Lluis
dc.contributor.authorGarcia-Caldentey, Juan
dc.contributor.authorCaballol, Nuria
dc.contributor.authorVives-Pastor, Barbara
dc.contributor.authorHernandez-Vara, Jorge
dc.contributor.authorCabo-Lopez, Iria
dc.contributor.authorLopez-Manzanares, Lydia
dc.contributor.authorGonzalez-Aramburu, Isabel
dc.contributor.authorAsuncion Avila-Rivera, Maria
dc.contributor.authorJose Catalan, Maria
dc.contributor.authorManuel Lopez-Diaz, Luis
dc.contributor.authorPuente, Victor
dc.contributor.authorManuel Garcia-Moreno, Jose
dc.contributor.authorBorrue, Carmen
dc.contributor.authorSolano-Vila, Berta
dc.contributor.authorAlvarez-Sauco, Maria
dc.contributor.authorVela, Lydia
dc.contributor.authorEscalante, Sonia
dc.contributor.authorCubo, Esther
dc.contributor.authorCarrillo-Padilla, Francisco
dc.contributor.authorCarlos Martinez-Castrillo, Juan
dc.contributor.authorSanchez-Alonso, Pilar
dc.contributor.authorGema Alonso-Losada, Maria
dc.contributor.authorLopez-Ariztegui, Nuria
dc.contributor.authorGaston, Itziar
dc.contributor.authorBlazquez-Estrada, Marta
dc.contributor.authorSeijo-Martinez, Manual
dc.contributor.authorRuiz-Martinez, Javier
dc.contributor.authorValero-Merino, Caridad
dc.contributor.authorKurtis, Monica
dc.contributor.authorDe Fabregues-Boixar, Oriol
dc.contributor.authorGonzalez-Ardura, Jessica
dc.contributor.authorPrieto-Jurczynska, Cristina
dc.contributor.authorMartinez-Martin, Pablo
dc.contributor.authorMir, Pablo
dc.contributor.authorKulisevsky, Jaime
dc.contributor.authorCOPPADIS Study
dc.contributor.authoraffiliation[Martinez-Horta, Saul] Hosp Santa Creu & Sant Pau, Movement Disorders Unit, Neurol Dept, Mas Casanovas 90, Barcelona 08041, Spain
dc.contributor.authoraffiliation[Bejr-Kasem, Helena] Hosp Santa Creu & Sant Pau, Movement Disorders Unit, Neurol Dept, Mas Casanovas 90, Barcelona 08041, Spain
dc.contributor.authoraffiliation[Horta-Barba, Andrea] Hosp Santa Creu & Sant Pau, Movement Disorders Unit, Neurol Dept, Mas Casanovas 90, Barcelona 08041, Spain
dc.contributor.authoraffiliation[Pascual-Sedano, Berta] Hosp Santa Creu & Sant Pau, Movement Disorders Unit, Neurol Dept, Mas Casanovas 90, Barcelona 08041, Spain
dc.contributor.authoraffiliation[Kulisevsky, Jaime] Hosp Santa Creu & Sant Pau, Movement Disorders Unit, Neurol Dept, Mas Casanovas 90, Barcelona 08041, Spain
dc.contributor.authoraffiliation[Martinez-Horta, Saul] IIB St Pau, Biomed Res Inst St Pau, Barcelona, Spain
dc.contributor.authoraffiliation[Bejr-Kasem, Helena] IIB St Pau, Biomed Res Inst St Pau, Barcelona, Spain
dc.contributor.authoraffiliation[Horta-Barba, Andrea] IIB St Pau, Biomed Res Inst St Pau, Barcelona, Spain
dc.contributor.authoraffiliation[Pascual-Sedano, Berta] IIB St Pau, Biomed Res Inst St Pau, Barcelona, Spain
dc.contributor.authoraffiliation[Kulisevsky, Jaime] IIB St Pau, Biomed Res Inst St Pau, Barcelona, Spain
dc.contributor.authoraffiliation[Martinez-Horta, Saul] Ctr Invest Red Enfermedades Neurodegenerat CIBERN, Madrid, Spain
dc.contributor.authoraffiliation[Bejr-Kasem, Helena] Ctr Invest Red Enfermedades Neurodegenerat CIBERN, Madrid, Spain
dc.contributor.authoraffiliation[Horta-Barba, Andrea] Ctr Invest Red Enfermedades Neurodegenerat CIBERN, Madrid, Spain
dc.contributor.authoraffiliation[Pascual-Sedano, Berta] Ctr Invest Red Enfermedades Neurodegenerat CIBERN, Madrid, Spain
dc.contributor.authoraffiliation[Jesus, Silvia] Ctr Invest Red Enfermedades Neurodegenerat CIBERN, Madrid, Spain
dc.contributor.authoraffiliation[Martinez-Martin, Pablo] Ctr Invest Red Enfermedades Neurodegenerat CIBERN, Madrid, Spain
dc.contributor.authoraffiliation[Mir, Pablo] Ctr Invest Red Enfermedades Neurodegenerat CIBERN, Madrid, Spain
dc.contributor.authoraffiliation[Kulisevsky, Jaime] Ctr Invest Red Enfermedades Neurodegenerat CIBERN, Madrid, Spain
dc.contributor.authoraffiliation[Santos-Garcia, Diego] Complejo Hosp Univ A Coruna, CHUAC, La Coruna, Spain
dc.contributor.authoraffiliation[De Deus-Fonticoba, Teresa] Complejo Hosp Univ Ferrol CHUF, Ferrol, A Coruna, Spain
dc.contributor.authoraffiliation[Jesus, Silvia] Univ Seville, Hosp Univ Virgen del Rocio, Inst Biomed Sevilla,CSIC, Unidad Trastornos Movimiento,Serv Neurol & Neuro, Seville, Spain
dc.contributor.authoraffiliation[Mir, Pablo] Univ Seville, Hosp Univ Virgen del Rocio, Inst Biomed Sevilla,CSIC, Unidad Trastornos Movimiento,Serv Neurol & Neuro, Seville, Spain
dc.contributor.authoraffiliation[Aguilar, Miquel] Hosp Univ Mutua de Terrassa, Barcelona, Spain
dc.contributor.authoraffiliation[Planellas, Lluis] Hosp Clin Barcelona, Barcelona, Spain
dc.contributor.authoraffiliation[Garcia-Caldentey, Juan] Hosp Quiron Palmaplanas, Clin Rotger, Palma De Mallorca, Spain
dc.contributor.authoraffiliation[Garcia-Caldentey, Juan] Ctr Neurol Oms 42, Palma De Mallorca, Spain
dc.contributor.authoraffiliation[Caballol, Nuria] Hosp Moises Broggi, Consorci Sanitari Integral, Barcelona, Spain
dc.contributor.authoraffiliation[Asuncion Avila-Rivera, Maria] Hosp Moises Broggi, Consorci Sanitari Integral, Barcelona, Spain
dc.contributor.authoraffiliation[Vives-Pastor, Barbara] Hosp Univ Son Espases, Palma De Mallorca, Spain
dc.contributor.authoraffiliation[Hernandez-Vara, Jorge] Vall DHebron Univ Campus, Neurol Dept, Barcelona, Spain
dc.contributor.authoraffiliation[De Fabregues-Boixar, Oriol] Vall DHebron Univ Campus, Neurol Dept, Barcelona, Spain
dc.contributor.authoraffiliation[Hernandez-Vara, Jorge] Vall DHebron Univ Campus, Neurodegenerat Dis Res Grp, Barcelona, Spain
dc.contributor.authoraffiliation[De Fabregues-Boixar, Oriol] Vall DHebron Univ Campus, Neurodegenerat Dis Res Grp, Barcelona, Spain
dc.contributor.authoraffiliation[Cabo-Lopez, Iria] Complejo Hosp Univ Pontevedra CHOP, Pontevedra, Spain
dc.contributor.authoraffiliation[Seijo-Martinez, Manual] Complejo Hosp Univ Pontevedra CHOP, Pontevedra, Spain
dc.contributor.authoraffiliation[Lopez-Manzanares, Lydia] Hosp Princesa, Madrid, Spain
dc.contributor.authoraffiliation[Gonzalez-Aramburu, Isabel] Hosp Univ Marques de Valdecilla, Santander, Spain
dc.contributor.authoraffiliation[Jose Catalan, Maria] Hosp Univ Clin San Carlos, Madrid, Spain
dc.contributor.authoraffiliation[Manuel Lopez-Diaz, Luis] Hosp Costa de Burela, Lugo, Spain
dc.contributor.authoraffiliation[Puente, Victor] Hosp Mar, Barcelona, Spain
dc.contributor.authoraffiliation[Manuel Garcia-Moreno, Jose] Hosp Univ Virgen Macarena, Seville, Spain
dc.contributor.authoraffiliation[Borrue, Carmen] Hosp Univ Infanta Sofia, Madrid, Spain
dc.contributor.authoraffiliation[Solano-Vila, Berta] Hosp Univ Josep Trueta, Girona, Spain
dc.contributor.authoraffiliation[Solano-Vila, Berta] Hosp Santa Caterina, Girona, Spain
dc.contributor.authoraffiliation[Alvarez-Sauco, Maria] Hosp Gen Univ Elche, Alicante, Spain
dc.contributor.authoraffiliation[Vela, Lydia] Fdn Hosp Alcorcon, Madrid, Spain
dc.contributor.authoraffiliation[Escalante, Sonia] Hosp Tortosa Verge de la Cinta HTVC, Tarragona, Spain
dc.contributor.authoraffiliation[Cubo, Esther] Complejo Asistencial Univ Burgos, Burgos, Spain
dc.contributor.authoraffiliation[Carrillo-Padilla, Francisco] Hosp Univ Canarias, Serv Neurol & Neurofisiol Clin, Unidad Trastornos Movimiento, Tenerife, Spain
dc.contributor.authoraffiliation[Carlos Martinez-Castrillo, Juan] Hosp Ramon & Cajal, Madrid, Spain
dc.contributor.authoraffiliation[Sanchez-Alonso, Pilar] Hosp Univ Puerta de Hierro, Madrid, Spain
dc.contributor.authoraffiliation[Gema Alonso-Losada, Maria] Complejo Hosp Univ Vigo CHUVI, Hosp Alvaro Cunqueiro, Vigo, Spain
dc.contributor.authoraffiliation[Lopez-Ariztegui, Nuria] Complejo Hosp Univ Toledo, Serv Neurol, Toledo, Spain
dc.contributor.authoraffiliation[Gaston, Itziar] Complejo Hosp Navarra, Pamplona, Spain
dc.contributor.authoraffiliation[Blazquez-Estrada, Marta] Hosp Univ Cent Asturias, Oviedo, Spain
dc.contributor.authoraffiliation[Ruiz-Martinez, Javier] Hosp Univ Donostia, San Sebastian, Spain
dc.contributor.authoraffiliation[Valero-Merino, Caridad] Hosp Arnau Vilanova, Serv Neurol, Valencia, Spain
dc.contributor.authoraffiliation[Kurtis, Monica] Hosp Ruber Int, Madrid, Spain
dc.contributor.authoraffiliation[Gonzalez-Ardura, Jessica] Hosp Lucus Augusti, Lugo, Spain
dc.contributor.authoraffiliation[Prieto-Jurczynska, Cristina] Hosp Rey Juan Carlos, Madrid, Spain
dc.contributor.authoraffiliation[Martinez-Martin, Pablo] Inst Salud Carlos III, Ctr Nacl Epidemiol, Madrid, Spain
dc.contributor.authoraffiliation[Martinez-Martin, Pablo] Inst Salud Carlos III, CIBERNED, Madrid, Spain
dc.contributor.authoraffiliation[Mir, Pablo] Univ Seville, Fac Med, Dept Med, Seville, Spain
dc.contributor.funderFundacion Curemos el Parkinson
dc.date.accessioned2025-01-07T16:41:34Z
dc.date.available2025-01-07T16:41:34Z
dc.date.issued2021-12-08
dc.description.abstractBackground Identifying modifiable risk factors for cognitive impairment in the early stages of Parkinson's disease (PD) and estimating their impact on cognitive status may help prevent dementia (PDD) and the design of cognitive trials. Methods Using a standard approach for the assessment of global cognition in PD and controlling for the effects of age, education and disease duration, we explored the associations between cognitive status, comorbidities, metabolic variables and lifestyle variables in 533 PD participants from the COPPADIS study. Results Among the overall sample, 21% of participants were classified as PD-MCI (n = 114) and 4% as PDD (n = 26). The prevalence of hypertension, diabetes and dyslipidemia was significantly higher in cognitively impaired patients while no between-group differences were found for smoking, alcohol intake or use of supplementary vitamins. Better cognitive scores were significantly associated with regular physical exercise (p
dc.identifier.doi10.1186/s12883-021-02485-1
dc.identifier.essn1471-2377
dc.identifier.pmid34879838
dc.identifier.unpaywallURLhttps://bmcneurol.biomedcentral.com/track/pdf/10.1186/s12883-021-02485-1
dc.identifier.urihttps://hdl.handle.net/10668/27946
dc.identifier.wosID728171100003
dc.issue.number1
dc.journal.titleBmc neurology
dc.journal.titleabbreviationBmc neurol.
dc.language.isoen
dc.organizationInstituto de Investigación Biomédica de Sevilla (IBIS)
dc.organizationSAS - Hospital Universitario Virgen del Rocío
dc.organizationSAS - Hospital Universitario Virgen Macarena
dc.publisherBmc
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectParkinson's disease
dc.subjectPD-MCI
dc.subjectCognition
dc.subjectLifestyle
dc.subjectCoppadis
dc.subjectPlasma homocysteine levels
dc.subjectDementia
dc.subjectImpairment
dc.subjectDecline
dc.subjectRisk
dc.subjectAssociation
dc.subjectMulticenter
dc.subjectPrevalence
dc.subjectCytokines
dc.subjectBeta
dc.titleIdentifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson's disease
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number21
dc.wostypeArticle

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