Cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study.

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dc.contributor.authorChuang, Shu-Chun
dc.contributor.authorBoeing, Heiner
dc.contributor.authorVollset, Stein Emil
dc.contributor.authorMidttun, Øivind
dc.contributor.authorUeland, Per Magne
dc.contributor.authorBueno-de-Mesquita, Bas
dc.contributor.authorLajous, Martin
dc.contributor.authorFagherazzi, Guy
dc.contributor.authorBoutron-Ruault, Marie-Christine
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorKüehn, Tilman
dc.contributor.authorPischon, Tobias
dc.contributor.authorDrogan, Dagmar
dc.contributor.authorTjønneland, Anne
dc.contributor.authorOvervad, Kim
dc.contributor.authorQuirós, J Ramón
dc.contributor.authorAgudo, Antonio
dc.contributor.authorMolina-Montes, Esther
dc.contributor.authorDorronsoro, Miren
dc.contributor.authorHuerta, José María
dc.contributor.authorBarricarte, Aurelio
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorWareham, Nicholas J
dc.contributor.authorTravis, Ruth C
dc.contributor.authorTrichopoulou, Antonia
dc.contributor.authorLagiou, Pagona
dc.contributor.authorTrichopoulos, Dimitrios
dc.contributor.authorMasala, Giovanna
dc.contributor.authorAgnoli, Claudia
dc.contributor.authorTumino, Rosario
dc.contributor.authorMattiello, Amalia
dc.contributor.authorPeeters, Petra H
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorPalmqvist, Richard
dc.contributor.authorLjuslinder, Ingrid
dc.contributor.authorGunter, Marc
dc.contributor.authorLu, Yunxia
dc.contributor.authorCross, Amanda J
dc.contributor.authorRiboli, Elio
dc.contributor.authorVineis, Paolo
dc.contributor.authorAleksandrova, Krasimira
dc.date.accessioned2025-01-07T12:33:09Z
dc.date.available2025-01-07T12:33:09Z
dc.date.issued2016-02-25
dc.description.abstractIncreased serum neopterin had been described in older age two decades ago. Neopterin is a biomarker of systemic adaptive immune activation that could be potentially implicated in metabolic syndrome (MetS). Measurements of waist circumference, triglycerides, high-density lipoprotein cholesterol (HDLC), systolic and diastolic blood pressure, glycated hemoglobin as components of MetS definition, and plasma total neopterin concentrations were performed in 594 participants recruited in the European Prospective Investigation into Cancer and Nutrition (EPIC). Higher total neopterin concentrations were associated with reduced HDLC (9.7 %, p  These data suggest that high total neopterin concentrations are cross-sectionally associated with reduced HDLC, but not with overall MetS.
dc.identifier.doi10.1186/s12979-016-0059-y
dc.identifier.issn1742-4933
dc.identifier.pmcPMC4766742
dc.identifier.pmid26918023
dc.identifier.pubmedURLhttps://pmc.ncbi.nlm.nih.gov/articles/PMC4766742/pdf
dc.identifier.unpaywallURLhttps://immunityageing.biomedcentral.com/track/pdf/10.1186/s12979-016-0059-y
dc.identifier.urihttps://hdl.handle.net/10668/24701
dc.journal.titleImmunity & ageing : I & A
dc.journal.titleabbreviationImmun Ageing
dc.language.isoen
dc.organizationEscuela Andaluza de Salud Pública
dc.organizationEscuela Andaluza de Salud Pública
dc.organizationInstituto de Investigación Biosanitaria de Granada (ibs.GRANADA)
dc.page.number5
dc.pubmedtypeJournal Article
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCell-mediated immunity
dc.subjectMetabolic syndrome
dc.subjectNeopterin
dc.titleCellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number13

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