Association between the APOA2 rs3813627 Single Nucleotide Polymorphism and HDL and APOA1 Levels Through BMI.
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2020-02-27
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Boughanem, Hatim
Bandera-Merchán, Borja
Hernández-Alonso, Pablo
Moreno-Morales, Noelia
Tinahones, Francisco José
Lozano, José
Morcillo, Sonsoles
Macias-Gonzalez, Manuel
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Abstract
Background: The interaction between obesity and genetic traits on high density lipoprotein (HDL) levels has been extensively studied. The variance of serum HDL has a strong genetic heritability, although the studied variant only explains a small part of this variation. The goal of this study was to investigate the associations between the apolipoprotein type 2 (APOA2) rs3813627 single nucleotide polymorphism (SNP) and anthropometric and biochemical variables, though body mass index (BMI). Methods: This study included 153 subjects (91 overweight/obese (BMI³25 kg/m2) and 62 non-obese individuals (BMI
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APOA1, APOA2, BMI, HDL, SNP, rs3813627