Vitamin D Status in Pediatric and Young Adult Cystic Fibrosis Patients. Are the New Recommendations Effective?
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Identifiers
Date
2021-12-01
Authors
Mangas-Sanchez, Carmen
Garriga-Garcia, Maria
Serrano-Nieto, Maria Juliana
Garcia-Romero, Ruth
alvarez-Beltran, Marina
Crehua-Gaudiza, Elena
Munoz-Codoceo, Rosana
Suarez-Cortina, Lucrecia
Vicente-Santamaria, Saioa
Martinez-Costa, Cecilia
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Mdpi
Abstract
Introduction: In recent years, guidelines for vitamin D supplementation have been updated and prophylactic recommended doses have been increased in patients with cystic fibrosis (CF). Objective: To evaluate safety and efficacy of these new recommendations. Results: Two cohorts of pancreatic insufficient CF patients were compared before (cohort 1: 179 patients) and after (cohort 2: 71 patients) American CF Foundation and European CF Society recommendations were published. Cohort 2 patients received higher Vitamin D doses: 1509 (1306-1711 95% CI) vs 1084 (983-1184 95% CI) IU/Day (p
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Keywords
vitamin D, cystic fibrosis, multicenter study, D insufficiency, D deficiency, Children, Cholecalciferol, Ergocalciferol