Emergence of cfr-Mediated Linezolid Resistance in a Methicillin-Resistant Staphylococcus aureus Epidemic Clone Isolated from Patients with Cystic Fibrosis

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dc.contributor.authorde Dios Caballero, Juan
dc.contributor.authorDolores Pastor, Maria
dc.contributor.authorVindel, Ana
dc.contributor.authorMaiz, Luis
dc.contributor.authorYague, Genoveva
dc.contributor.authorSalvador, Carme
dc.contributor.authorCobo, Marta
dc.contributor.authorMorosini, Maria-Isabel
dc.contributor.authordel Campo, Rosa
dc.contributor.authorCanton, Rafael
dc.contributor.authorGEIFQ Study Grp
dc.contributor.authoraffiliation[de Dios Caballero, Juan] Hosp Univ Ramon y Cajal, Microbiol Serv, Madrid, Spain
dc.contributor.authoraffiliation[Cobo, Marta] Hosp Univ Ramon y Cajal, Microbiol Serv, Madrid, Spain
dc.contributor.authoraffiliation[Morosini, Maria-Isabel] Hosp Univ Ramon y Cajal, Microbiol Serv, Madrid, Spain
dc.contributor.authoraffiliation[del Campo, Rosa] Hosp Univ Ramon y Cajal, Microbiol Serv, Madrid, Spain
dc.contributor.authoraffiliation[Canton, Rafael] Hosp Univ Ramon y Cajal, Microbiol Serv, Madrid, Spain
dc.contributor.authoraffiliation[de Dios Caballero, Juan] Inst Ramon y Cajal Invest Sanitaria, Madrid, Spain
dc.contributor.authoraffiliation[Cobo, Marta] Inst Ramon y Cajal Invest Sanitaria, Madrid, Spain
dc.contributor.authoraffiliation[Morosini, Maria-Isabel] Inst Ramon y Cajal Invest Sanitaria, Madrid, Spain
dc.contributor.authoraffiliation[del Campo, Rosa] Inst Ramon y Cajal Invest Sanitaria, Madrid, Spain
dc.contributor.authoraffiliation[Canton, Rafael] Inst Ramon y Cajal Invest Sanitaria, Madrid, Spain
dc.contributor.authoraffiliation[de Dios Caballero, Juan] REIPI, Madrid, Spain
dc.contributor.authoraffiliation[Morosini, Maria-Isabel] REIPI, Madrid, Spain
dc.contributor.authoraffiliation[del Campo, Rosa] REIPI, Madrid, Spain
dc.contributor.authoraffiliation[Canton, Rafael] REIPI, Madrid, Spain
dc.contributor.authoraffiliation[Dolores Pastor, Maria] Hosp Univ Virgen Arrixaca, Serv Neumol, Murcia, Spain
dc.contributor.authoraffiliation[Vindel, Ana] Inst Salud Carlos III, Ctr Nacl Microbiol, Serv Bacteriol, Staphylococcus Reference Lab, Madrid, Spain
dc.contributor.authoraffiliation[Maiz, Luis] Hosp Univ Ramon y Cajal, Serv Neumol, Madrid, Spain
dc.contributor.authoraffiliation[Yague, Genoveva] Hosp Univ Virgen Arrixaca, Microbiol Serv, Murcia, Spain
dc.contributor.authoraffiliation[Salvador, Carme] Hosp Univ Virgen Arrixaca, Microbiol Serv, Murcia, Spain
dc.contributor.funderREIPI
dc.contributor.funderInstituto de Salud Carlos III (ISCIII)
dc.contributor.funderMINECO
dc.date.accessioned2025-01-07T15:37:31Z
dc.date.available2025-01-07T15:37:31Z
dc.date.issued2016-03-01
dc.description.abstractResistance to linezolid (LZD) in methicillin-resistant Staphylococcus aureus (MRSA) isolates from patients with cystic fibrosis (CF) is due mainly to ribosomal mutations. We report on four CF patients with LZD-resistant MRSA bronchopulmonary infections by strains carrying the cfr gene. Strains from one patient also harbored the G2576U mutation (23S rRNA) and the G139R substitution (L3 protein). All strains belonged to the epidemic clone ST125 MRSA IVc. Our results support the monitoring of LZD resistance emergence in CF and non-CF MRSA isolates.
dc.identifier.doi10.1128/AAC.02067-15
dc.identifier.essn1098-6596
dc.identifier.issn0066-4804
dc.identifier.pmid26666940
dc.identifier.unpaywallURLhttps://aac.asm.org/content/aac/60/3/1878.full.pdf
dc.identifier.urihttps://hdl.handle.net/10668/27280
dc.identifier.wosID376490800090
dc.issue.number3
dc.journal.titleAntimicrobial agents and chemotherapy
dc.journal.titleabbreviationAntimicrob. agents chemother.
dc.language.isoen
dc.organizationSAS - Hospital Universitario Virgen del Rocío
dc.page.number1878-1882
dc.publisherAmer soc microbiology
dc.rights.accessRightsopen access
dc.subjectClinical isolate
dc.subjectGene
dc.subjectMechanisms
dc.subjectInfection
dc.subjectStrain
dc.titleEmergence of cfr-Mediated Linezolid Resistance in a Methicillin-Resistant Staphylococcus aureus Epidemic Clone Isolated from Patients with Cystic Fibrosis
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number60
dc.wostypeArticle

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