Expert recommendations on the management of patients with metastatic castration-resistant prostate cancer who progress after CHAARTED or LATITUDE.
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Identifiers
Date
2020-03-19
Authors
Puente, Javier
Anido, Urbano
Climent, Miguel Angel
Gonzalez-Billalabeitia, Enrique
Lainez, Nuria
Lambea, Julio
Maroto, Jose Pablo
Mendez-Vidal, Maria Jose
Montesa, Alvaro
Rodriguez, Angel
Advisors
Journal Title
Journal ISSN
Volume Title
Publisher
Sage Publications
Abstract
Our aim was to provide practical recommendations on the management of patients with metastatic castration-resistant prostate cancer (mCRPC) who have progressed after docetaxel plus androgen-deprivation therapy (ADT) or abiraterone plus ADT. Systematic literature review (SLR), nominal group meeting, and Delphi process. A panel of 12 experts was established who defined the scope, users, and sections of the document. We performed an SLR in order to assess the efficacy and safety of available drugs in patients with mCRPC. Abstracts from the American Society of Oncology and European Society for Medical Oncology meetings were also examined. The results were discussed during an expert meeting in which 14 recommendations were generated. The level of agreement with the recommendations was also tested by 13 additional experts following the Delphi process. Recommendations were voted by means of scores ranging from 0 (total disagreement) to 10 (total agreement). We defined agreement when at least 70% of the experts voted ⩾7. Next, we assigned a level of evidence and grade to the recommendation using the Oxford Centre for Evidence-based Medicine Levels of Evidence, following which the final document was drafted. The literature search did not find any articles meeting the inclusion criteria. Finally, 13 out of 14 recommendations were accepted after two Delphi rounds (two were modified after the first round). They pertain to general and individual case-based treatment recommendations. In mCRPC patients who have progressed after docetaxel or abiraterone plus ADT in the metastatic hormone-sensitive prostate cancer setting, these recommendations may support treatment decision-making, due to the lack of evidence or other globally accepted sequencing algorithms.
Description
MeSH Terms
Docetaxel
Prostatic Neoplasms, Castration-Resistant
Androgen Antagonists
Evidence-Based Medicine
Medical Oncology
Prostatic Neoplasms, Castration-Resistant
Androgen Antagonists
Evidence-Based Medicine
Medical Oncology
DeCS Terms
Neoplasias de la Próstata
Hormonas
Toma de Decisiones
Oncología Médica
Medicina Basada en la Evidencia
Castración
Hormonas
Toma de Decisiones
Oncología Médica
Medicina Basada en la Evidencia
Castración
CIE Terms
Keywords
Abiraterone acetate, Androgen-deprivation therapy, Chemotherapy, Enzalutamide, Metastatic castration-resistant prostate cancer, Radium-223
Citation
Puente J, Anido U, Climent MÁ, Gonzalez-Billalabeitia E, Lainez N, Lambea J, et al. Expert recommendations on the management of patients with metastatic castration-resistant prostate cancer who progress after CHAARTED or LATITUDE. Ther Adv Med Oncol. 2020 May 27;12:1758835920920067