Single nucleotide variations in ZBTB46 are associated with post-thrombolytic parenchymal haematoma.

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dc.contributor.authorCarrera, Caty
dc.contributor.authorCárcel-Márquez, Jara
dc.contributor.authorCullell, Natalia
dc.contributor.authorTorres-Águila, Nuria
dc.contributor.authorMuiño, Elena
dc.contributor.authorCastillo, José
dc.contributor.authorSobrino, Tomás
dc.contributor.authorCampos, Francisco
dc.contributor.authorRodríguez-Castro, Emilio
dc.contributor.authorLlucià-Carol, Laia
dc.contributor.authorMillán, Mònica
dc.contributor.authorMuñoz-Narbona, Lucía
dc.contributor.authorLópez-Cancio, Elena
dc.contributor.authorBustamante, Alejandro
dc.contributor.authorRibó, Marc
dc.contributor.authorÁlvarez-Sabín, José
dc.contributor.authorJiménez-Conde, Jordi
dc.contributor.authorRoquer, Jaume
dc.contributor.authorGiralt-Steinhauer, Eva
dc.contributor.authorSoriano-Tárraga, Carolina
dc.contributor.authorMola-Caminal, Marina
dc.contributor.authorVives-Bauza, Cristófol
dc.contributor.authorNavarro, Rosa Díaz
dc.contributor.authorTur, Silvia
dc.contributor.authorObach, Victor
dc.contributor.authorArenillas, Juan Francisco
dc.contributor.authorSegura, Tomás
dc.contributor.authorSerrano-Heras, Gemma
dc.contributor.authorMartí-Fàbregas, Joan
dc.contributor.authorDelgado-Mederos, Raquel
dc.contributor.authorFreijo-Guerrero, M Mar
dc.contributor.authorMoniche, Francisco
dc.contributor.authorCabezas, Juan Antonio
dc.contributor.authorCastellanos, Mar
dc.contributor.authorGallego-Fabrega, Cristina
dc.contributor.authorGonzález-Sanchez, Jonathan
dc.contributor.authorKrupinsky, Jurek
dc.contributor.authorStrbian, Daniel
dc.contributor.authorTatlisumak, Turgut
dc.contributor.authorThijs, Vincent
dc.contributor.authorLemmens, Robin
dc.contributor.authorSlowik, Agnieszka
dc.contributor.authorPera, Johanna
dc.contributor.authorKittner, Steven
dc.contributor.authorCole, John
dc.contributor.authorHeitsch, Laura
dc.contributor.authorIbañez, Laura
dc.contributor.authorCruchaga, Carlos
dc.contributor.authorLee, Jin-Moo
dc.contributor.authorMontaner, Joan
dc.contributor.authorFernández-Cadenas, Israel
dc.date.accessioned2025-01-07T16:18:12Z
dc.date.available2025-01-07T16:18:12Z
dc.date.issued2021
dc.description.abstractHaemorrhagic transformation is a complication of recombinant tissue-plasminogen activator treatment. The most severe form, parenchymal haematoma, can result in neurological deterioration, disability, and death. Our objective was to identify single nucleotide variations associated with a risk of parenchymal haematoma following thrombolytic therapy in patients with acute ischaemic stroke. A fixed-effect genome-wide meta-analysis was performed combining two-stage genome-wide association studies (n = 1904). The discovery stage (three cohorts) comprised 1324 ischaemic stroke individuals, 5.4% of whom had a parenchymal haematoma. Genetic variants yielding a P-value
dc.identifier.doi10.1093/brain/awab090
dc.identifier.essn1460-2156
dc.identifier.pmcPMC8418348
dc.identifier.pmid33723576
dc.identifier.pubmedURLhttps://pmc.ncbi.nlm.nih.gov/articles/PMC8418348/pdf
dc.identifier.unpaywallURLhttps://academic.oup.com/brain/article-pdf/144/8/2416/40305952/awab090.pdf
dc.identifier.urihttps://hdl.handle.net/10668/27741
dc.issue.number8
dc.journal.titleBrain : a journal of neurology
dc.journal.titleabbreviationBrain
dc.language.isoen
dc.organizationInstituto de Investigación Biomédica de Sevilla (IBIS)
dc.organizationSAS - Hospital Universitario Virgen del Rocío
dc.page.number2416-2426
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, N.I.H., Extramural
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.rights.accessRightsopen access
dc.subjectGWAS
dc.subjectischaemic stroke
dc.subjectparenchymal haematoma
dc.subjectpharmacogenetics
dc.subjectthrombolysis
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshCerebral Hemorrhage
dc.subject.meshFemale
dc.subject.meshFibrinolytic Agents
dc.subject.meshGenome-Wide Association Study
dc.subject.meshHumans
dc.subject.meshIschemic Stroke
dc.subject.meshMale
dc.subject.meshMiddle Aged
dc.subject.meshPolymorphism, Single Nucleotide
dc.subject.meshThrombolytic Therapy
dc.subject.meshTissue Plasminogen Activator
dc.subject.meshTranscription Factors
dc.subject.meshTreatment Outcome
dc.titleSingle nucleotide variations in ZBTB46 are associated with post-thrombolytic parenchymal haematoma.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number144

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