The RhoB small GTPase in physiology and disease.

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dc.contributor.authorVega, Francisco M
dc.contributor.authorRidley, Anne J
dc.date.accessioned2025-01-07T13:17:38Z
dc.date.available2025-01-07T13:17:38Z
dc.date.issued2016-11-22
dc.description.abstractRhoB is a Rho family GTPase that is highly similar to RhoA and RhoC, yet has distinct functions in cells. Its unique C-terminal region is subject to specific post-translational modifications that confer different localization and functions to RhoB. Apart from the common role with RhoA and RhoC in actin organization and cell migration, RhoB is also implicated in a variety of other cellular processes including membrane trafficking, cell proliferation, DNA-repair and apoptosis. RhoB is not an essential gene in mice, but it is implicated in several physiological and pathological processes. Its multiple roles will be discussed in this review.
dc.identifier.doi10.1080/21541248.2016.1253528
dc.identifier.essn2154-1256
dc.identifier.pmcPMC5997158
dc.identifier.pmid27875099
dc.identifier.pubmedURLhttps://pmc.ncbi.nlm.nih.gov/articles/PMC5997158/pdf
dc.identifier.unpaywallURLhttps://www.tandfonline.com/doi/pdf/10.1080/21541248.2016.1253528?needAccess=true
dc.identifier.urihttps://hdl.handle.net/10668/25394
dc.issue.number5
dc.journal.titleSmall GTPases
dc.journal.titleabbreviationSmall GTPases
dc.language.isoen
dc.organizationSAS - Hospital Universitario Reina Sofía
dc.page.number384-393
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.pubmedtypeReview
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectRho GTPases
dc.subjectRhoB
dc.subjectcancer progression
dc.subjectdevelopment
dc.subjectmembrane trafficking
dc.subject.meshAmino Acid Sequence
dc.subject.meshAnimals
dc.subject.meshDisease
dc.subject.meshGrowth and Development
dc.subject.meshHumans
dc.subject.meshNeoplasms
dc.subject.meshNeovascularization, Physiologic
dc.subject.meshrhoB GTP-Binding Protein
dc.titleThe RhoB small GTPase in physiology and disease.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number9

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