Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/845
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dc.contributor.authorQueipo-Ortuño, María Isabel-
dc.contributor.authorEscoté, Xavier-
dc.contributor.authorCeperuelo-Mallafré, María Victoria-
dc.contributor.authorGarrido-Sánchez, Lourdes-
dc.contributor.authorMiranda, Merce-
dc.contributor.authorClemente-Postigo, Mercedes-
dc.contributor.authorPérez-Pérez, Rafael-
dc.contributor.authorPeral, Belén-
dc.contributor.authorCardona Díaz, Fernando-
dc.contributor.authorFernández-Real, José Manuel-
dc.contributor.authorTinahones Madueño, Francisco José-
dc.contributor.authorVendrell, Joan-
dc.date.accessioned2013-03-18T09:50:35Z-
dc.date.available2013-03-18T09:50:35Z-
dc.date.issued2012-11-05-
dc.identifier.citationQueipo-Ortuño MI, Escoté X, Ceperuelo-Mallafré MV, Garrido-Sanchez L, Miranda M, Clemente-Postigo M, et al. FABP4 Dynamics in Obesity: Discrepancies in Adipose Tissue and Liver Expression Regarding Circulating Plasma Levels. PLoS ONE. 2012; 7(11):e48605es
dc.identifier.issn1932-6203 (Online)-
dc.identifier.otherPMC3489666-
dc.identifier.urihttp://hdl.handle.net/10668/845-
dc.descriptionJournal Article;es
dc.description.abstractBACKGROUND FABP4 is predominantly expressed in adipose tissue, and its circulating levels are linked with obesity and a poor atherogenic profile. OBJECTIVE In patients with a wide BMI range, we analyze FABP4 expression in adipose and hepatic tissues in the settings of obesity and insulin resistance. Associations between FABP4 expression in adipose tissue and the FABP4 plasma level as well as the main adipogenic and lipolytic genes expressed in adipose tissue were also analyzed. METHODS The expression of several lipogenic, lipolytic, PPAR family and FABP family genes was analyzed by real time PCR. FABP4 protein expression in total adipose tissues and its fractions were determined by western blot. RESULTS In obesity FABP4 expression was down-regulated (at both mRNA and protein levels), with its levels mainly predicted by ATGL and inversely by the HOMA-IR index. The BMI appeared as the only determinant of the FABP4 variation in both adipose tissue depots. FABP4 plasma levels showed a significant progressive increase according to BMI but no association was detected between FABP4 circulating levels and SAT or VAT FABP4 gene expression. The gene expression of FABP1, FABP4 and FABP5 in hepatic tissue was significantly higher in tissue from the obese IR patients compared to the non-IR group. CONCLUSION The inverse pattern in FABP4 expression between adipose and hepatic tissue observed in morbid obese patients, regarding the IR context, suggests that both tissues may act in a balanced manner. These differences may help us to understand the discrepancies between circulating plasma levels and adipose tissue expression in obesity.es
dc.description.sponsorshipThis work was supported by Fondo de Investigacion Sanitaria (FIS) 07/1024, 08/1195, CB06/03/0018, CP07/0095 and PI081655, 10/00967, 11/00085 from the Spanish Instituto de Salud Carlos III (ISCIII), Ministerio de Sanidad y Consumo; with the participation of the European Regional Development Fund (ERDF) SAF-2009-10461 from the Ministerio de Economia y Competitividad (MICINN), the Servicio Andaluz de Salud (PI325/2008) and Fundación Mutua Madrileñaa, Spain (BP). LGS and VCM are supported by fellowships from the Juan de la Cierva programme (JdlC) (JCI200904086 and JCI-2010-06395). CIBERs are an ISCIII Project.es
dc.language.isoenes
dc.publisherPublic Library of Sciencees
dc.relation.ispartofPloS onees
dc.subjectResistencia a la Insulinaes
dc.subjectObesidad Mórbidaes
dc.subjectObesidades
dc.subjectProteínas de Unión a Ácidos Grasoses
dc.subjectARN Mensajeroes
dc.subjectReceptores Activados del Proliferador del Peroxisomaes
dc.subjectTejido Adiposoes
dc.subjectHígadoes
dc.subjectExperimentación Animales
dc.subjectÍndice de Masa Corporales
dc.subjectGrasa Intraabdominales
dc.subjectSecuencia de Baseses
dc.subjectReacción en Cadena en Tiempo Real de la Polimerasaes
dc.subjectTejido Subcutáneoes
dc.subject.meshMedical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Hyperinsulinism::Insulin Resistancees
dc.subject.meshMedical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity::Obesity, Morbides
dc.subject.meshMedical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesityes
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Carrier Proteins::Fatty Acid-Binding Proteinses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleic Acids::RNA::RNA, Messengeres
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::DNA-Binding Proteins::Receptors, Cytoplasmic and Nuclear::Peroxisome Proliferator-Activated Receptorses
dc.subject.meshMedical Subject Headings::Anatomy::Tissues::Connective Tissue::Adipose Tissuees
dc.subject.meshMedical Subject Headings::Anatomy::Digestive System::Liveres
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Animal Experimentationes
dc.subject.meshMedical Subject Headings::Health Care::Environment and Public Health::Public Health::Epidemiologic Measurements::Biometry::Anthropometry::Body Mass Indexes
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses
dc.subject.meshMedical Subject Headings::Anatomy::Tissues::Connective Tissue::Adipose Tissue::Adipose Tissue, White::Abdominal Fat::Intra-Abdominal Fates
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Molecular Structure::Base Sequencees
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Nucleic Acid Amplification Techniques::Polymerase Chain Reaction::Real-Time Polymerase Chain Reactiones
dc.subject.meshMedical Subject Headings::Anatomy::Tissues::Connective Tissue::Subcutaneous Tissuees
dc.titleFABP4 Dynamics in Obesity: Discrepancies in Adipose Tissue and Liver Expression Regarding Circulating Plasma Levels.es
dc.typeinfo:eu-repo/semantics/articlees
dc.description.versionYeses
dc.identifier.pmid23139800-
dc.rights.accessRightsAcceso abiertoes
dc.identifier.doi10.1371/journal.pone.0048605-
dc.type.versioninfo:eu-repo/semantics/publishedes
dc.relation.publisherversionhttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0048605es
dc.contributor.authoraffiliation[Queipo-Ortuño,MI; Ceperuelo-Mallafré,MV; Clemente-Postigo,M; Cardona Díaz,F] Laboratorio de Investigaciones Biomédicas del Hospital Universitario Virgen de la Victoria, Málaga, Spain. [Queipo-Ortuño,MI; Ceperuelo-Mallafré,MV; Clemente-Postigo,M; Cardona Díaz,F] Fundación IMABIS, Málaga, Spain. [Queipo-Ortuño,MI; Pérez-Pérez,R; Peral,B; Cardona Díaz,F; Fernández-Real,JM; Tinahones Madueño,FJ] CIBER de Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. [Escoté,X; Garrido-Sánchez,L; Miranda,M; Vendrell,J] Endocrinology and Diabetes Unit.Joan XXIII University Hospital, IISPV, Universitat Rovira i Virgili, Tarragona, Spain. [Escoté,X; Ceperuelo-Mallafré,MV; Garrido-Sánchez,L; Miranda,M; Vendrell,J] CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain. [Pérez-Pérez,R; Peral,B] Instituto de Investigaciones Biomédicas, Alberto Sols, Consejo Superior de Investigaciones Científicas (CSIC) & Universidad Autónoma de Madrid (UAM), Madrid, Spain. [Fernández-Real,JM] Diabetes, Endocrinology and Nutrition Service, Institut d’Investigació Biomèdica de Girona (IdIBGi), Girona, Spain. [Tinahones Madueño,FJ] Servicio Endocrinología y Nutrición del Hospital Universitario Virgen de la Victoria, Málaga, Spain.es
dc.type.subtypeArtículoes
Appears in Collections:01- Artículos - Hospital Virgen de la Victoria
01- Artículos - IBIMA. Instituto de Investigación Biomédica de Málaga

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