Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/726
Title: Executive functions profile in extreme eating/weight conditions: from anorexia nervosa to obesity.
Authors: Fagundo, Ana B
Torre, Rafael de la
Jiménez-Murcia, Susana
Agüera, Zaida
Granero, Roser
Tárrega, Salomé
Botella, Cristina
Baños, Rosa
Fernández-Real, Jose M
Rodríguez, Roser
Forcano, Laura
Frühbeck, Gema
Gómez-Ambrosi, Javier
Tinahones Madueño, Francisco José
Fernández-García, Jose Carlos
Casanueva, Felipe F
Fernández-Aranda, Fernando
metadata.dc.contributor.authoraffiliation: [Fagundo,AB; Fernández-Aranda,F] Department of Psychiatry, University Hospital of Bellvitge-IDIBELL, Barcelona, Spain. [de la Torre,R; Jiménez-Murcia,S; Agüera,Z; Granero,R; Tárrega,S; Botella,C; Baños,R; Fernández-Real,JM; Rodríguez,R; Forcano,L; Frühbeck,G; Gómez-Ambrosi,J; Tinahones Madueño,FJ; Fernández-García,JC; Casanueva,FF; Fernández-Aranda,F] CIBER Fisiopatología Obesidad y Nutrición (CIBERObn), Instituto Salud Carlos III, Spain. [de la Torre,R] Human Pharmacology and Clinical Neurosciences Research Group, Neuroscience Research Program, IMIM-Hospital del Mar Research Institute, Parc de Salut Mar, Barcelona, Spain. [Jiménez-Murcia,S; Fernández Aranda,F] Department of Clinical Sciences, School of Medicine, University of Barcelona, Spain. [Granero,R; Tárrega,S] Laboratori d’Estadística Aplicada, Departament de Psicobiologia i Metodologia, Universitat Autònoma de Barcelona, Spain. [Botella,C] Department of Basic Psychology, Clinic and Psychobiology, University Jaume I, Castellón, Spain. [Baños,R] Department of Pyschological, Personality, Evaluation and Treatment, University of Valencia, Spain. [Fernández-Real,JM; Rodríguez,R] Service of Diabetes, Endocrinology and Nutrition, Institut d’Investigació Biomèdica de Girona (IdlBGi) Hospital Dr Josep Trueta, Girona, Spain. [Frühbeck,G; Gómez-Ambrosi,J] Department of Endocrinology, University of Navarra, Pamplona, Spain. [Tinahones Madueño,FJ; Fernández García,JC] Service of Diabetes, Endocrinology and Nutrition, Hospital Universitario Virgen de la Victoria, Málaga, Spain. [Casanueva,F] Endocrine Division, Complejo Hospitalario U. de Santiago, Santiago de Compostela University, Spain.
Keywords: Anorexia Nerviosa;Trastorno por Déficit de Atención con Hiperactividad;Obesidad;Pruebas Neuropsicológicas;Toma de Conciencia;Imagen Corporal
metadata.dc.subject.mesh: Medical Subject Headings::Psychiatry and Psychology::Mental Disorders::Eating Disorders::Anorexia Nervosa
Medical Subject Headings::Psychiatry and Psychology::Mental Disorders::Mental Disorders Diagnosed in Childhood::Attention Deficit and Disruptive Behavior Disorders::Attention Deficit Disorder with Hyperactivity
Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Nutrition Disorders::Overnutrition::Obesity
Medical Subject Headings::Psychiatry and Psychology::Behavioral Disciplines and Activities::Psychological Tests::Neuropsychological Tests
Medical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Cognition::Awareness
Medical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Perception::Body Image
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Issue Date: Aug-2012
Publisher: Public Library of Science
Citation: Fagundo AB, de la Torre R, Jiménez-Murcia S, Agüera Z, Granero R, Tárrega S, et al. Executive functions profile in extreme eating/weight conditions: from anorexia nervosa to obesity. PLoS ONE. 2012; 7(8):e43382
Abstract: BACKGROUND Extreme weight conditions (EWC) groups along a continuum may share some biological risk factors and intermediate neurocognitive phenotypes. A core cognitive trait in EWC appears to be executive dysfunction, with a focus on decision making, response inhibition and cognitive flexibility. Differences between individuals in these areas are likely to contribute to the differences in vulnerability to EWC. The aim of the study was to investigate whether there is a common pattern of executive dysfunction in EWC while comparing anorexia nervosa patients (AN), obese subjects (OB) and healthy eating/weight controls (HC). METHODS Thirty five AN patients, fifty two OB and one hundred thirty seven HC were compared using the Wisconsin Card Sorting Test (WCST); Stroop Color and Word Test (SCWT); and Iowa Gambling Task (IGT). All participants were female, aged between 18 and 60 years. RESULTS There was a significant difference in IGT score (F(1.79); p<.001), with AN and OB groups showing the poorest performance compared to HC. On the WCST, AN and OB made significantly more errors than controls (F(25.73); p<.001), and had significantly fewer correct responses (F(2.71); p<.001). Post hoc analysis revealed that the two clinical groups were not significantly different from each other. Finally, OB showed a significant reduced performance in the inhibition response measured with the Stroop test (F(5.11); p<.001) compared with both AN and HC. CONCLUSIONS These findings suggest that EWC subjects (namely AN and OB) have similar dysfunctional executive profile that may play a role in the development and maintenance of such disorders.
Description: Journal Article; Research Support, Non-U.S. Gov't;
URI: http://hdl.handle.net/10668/726
metadata.dc.relation.publisherversion: http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0043382
metadata.dc.identifier.doi: 10.1371/journal.pone.0043382
ISSN: 1932-6203 (Online)
Appears in Collections:01- Artículos - Hospital Virgen de la Victoria

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