Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/634
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dc.contributor.authorBalsa, Alejandro-
dc.contributor.authorCabezón, Arancha-
dc.contributor.authorOrozco, Gisela-
dc.contributor.authorCobo, Tatiana-
dc.contributor.authorMiranda-Carus, Eugenia-
dc.contributor.authorLópez-Nevot, Miguel Angel-
dc.contributor.authorVicario, José Luis-
dc.contributor.authorMartín-Mola, Emilio-
dc.contributor.authorMartín, Javier-
dc.contributor.authorPascual-Salcedo, Dora-
dc.date.accessioned2012-11-21T11:04:43Z-
dc.date.available2012-11-21T11:04:43Z-
dc.date.issued2010-04-06-
dc.identifier.citationBalsa A, Cabezón A, Orozco G, Cobo T, Miranda-Carus E, López-Nevot MA, et al. Influence of HLA DRB1 alleles in the susceptibility of rheumatoid arthritis and the regulation of antibodies against citrullinated proteins and rheumatoid factor. Arthritis Res. Ther.; 12(2):R62es
dc.identifier.issn1478-6362 (Online)-
dc.identifier.issn1478-6354 (Print)-
dc.identifier.urihttp://hdl.handle.net/10668/634-
dc.descriptionJournal Article; Research Support, Non-U.S. Gov't;es
dc.description.abstractINTRODUCTION The purpose of this study was to investigate the association between HLA-DRB1 alleles with susceptibility to rheumatoid arthritis (RA) and production of antibodies against citrullinated proteins (ACPA) and rheumatoid factor (RF). METHODS We studied 408 patients (235 with RA, 173 non-RA) and 269 controls. ACPA, RF and HLA-DR typing were determined. RESULTS We found an increased frequency of HLA DRB1 alleles with the shared epitope (SE) in ACPA-positive RA. Inversely, HLA DRB1 alleles encoding DERAA sequences were more frequent in controls than in ACPA-positive RA, and a similar trend was found for HLA DR3. However, these results could not be confirmed after stratification for the presence of the SE, probably due to the relatively low number of patients. These data may suggest that the presence of these alleles may confer a protective role for ACPA-positive RA. In RA patients we observed association between SE alleles and ACPA titers in a dose-dependent effect. The presence of HLA DR3 or DERAA-encoding alleles was associated with markedly reduced ACPA levels. No association between RF titers and HLA DR3 or DERAA-encoding alleles was found. CONCLUSIONS HLA DRB1 alleles with the SE are associated with production of ACPA. DERAA-encoding HLA-DR alleles and HLA DR3 may be protective for ACPA-positive RA.es
dc.description.sponsorshipThis work was supported by Fundacion Mutua Madrileña PI-668 and Beca FER-Abbott 2004es
dc.language.isoenes
dc.publisherBioMed Centrales
dc.relation.ispartofArthritis research & therapyes
dc.subjectSecuencias de Aminoácidoses
dc.subjectArtritis Reumatoidees
dc.subjectAutoanticuerposes
dc.subjectEpítoposes
dc.subjectFemeninoes
dc.subjectMarcadores Genéticoses
dc.subjectPredisposición Genética a la Enfermedades
dc.subjectAntígenos HLA-DRes
dc.subjectCadenas HLA-DRB1es
dc.subjectHumanoses
dc.subjectMasculinoes
dc.subjectMediana Edades
dc.subjectPéptidos Cíclicoses
dc.subjectConformación Proteicaes
dc.subjectFactor Reumatoidees
dc.subject.meshMedical Subject Headings::Diseases::Musculoskeletal Diseases::Joint Diseases::Arthritis::Arthritis, Rheumatoides
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Autoantibodieses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Biological Factors::Antigens::Epitopeses
dc.subject.meshMedical Subject Headings::Check Tags::Femalees
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Phenotype::Genetic Markerses
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype::Genetic Predisposition to Diseasees
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Glycoproteins::Membrane Glycoproteins::Histocompatibility Antigens Class II::HLA-D Antigens::HLA-DR Antigenses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Glycoproteins::Membrane Glycoproteins::Histocompatibility Antigens Class II::HLA-D Antigens::HLA-DR Antigens::HLA-DR beta-Chains::HLA-DRB1 Chainses
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses
dc.subject.meshMedical Subject Headings::Check Tags::Malees
dc.subject.meshMedical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Agedes
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Polycyclic Compounds::Macrocyclic Compounds::Peptides, Cyclices
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Molecular Structure::Molecular Conformation::Protein Conformationes
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Autoantibodies::Rheumatoid Factores
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Chemical Phenomena::Biochemical Phenomena::Molecular Structure::Amino Acid Sequence::Amino Acid Motifses
dc.titleInfluence of HLA DRB1 alleles in the susceptibility of rheumatoid arthritis and the regulation of antibodies against citrullinated proteins and rheumatoid factor.es
dc.typeinfo:eu-repo/semantics/articlees
dc.description.versionYeses
dc.identifier.pmid20370905-
dc.rights.accessRightsAcceso abiertoes
dc.identifier.doi10.1186/ar2975-
dc.type.versioninfo:eu-repo/semantics/publishedes
dc.relation.publisherversionhttp://arthritis-research.com/content/12/2/R62es
dc.contributor.authoraffiliation[Balsa,A; Cobo,T;,Miranda-Carus,E; Martín-Mola,E] Servicio de Reumatología, Hospital Universitario La Paz, Madrid, Spain.[Cabezón,A;Pascual-Salcedo,D] Sección de Inmunología, Hospital Universitario La Paz, Madrid, Spain. [Orozco,G;Martín,J] Instituto de Parasitología y Biomedicina López-Neyra, Granada, Spain. [López-Nevot,MA] Unidad de Inmunología, Hospital Universitario Virgen de las Nieves,Granada,Spain. [Vicario,JL] Unidad de Histocompatibilidad, Centro de Transfusión de la Comunidad de Madrid, Madrid, Spaines
dc.type.subtypeArtículoes
Appears in Collections:01- Artículos - Hospital Virgen de las Nieves

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