Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/622
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dc.contributor.authorGarrido-Sánchez, Lourdes-
dc.contributor.authorGarcía-Fuentes, E-
dc.contributor.authorRojo-Martínez, Gemma-
dc.contributor.authorCardona, Fernando-
dc.contributor.authorSoriguer, Federico-
dc.contributor.authorTinahones Madueño, Francisco José-
dc.date.accessioned2012-11-14T10:09:57Z-
dc.date.available2012-11-14T10:09:57Z-
dc.date.issued2008-02-06-
dc.identifier.citationGarrido-Sánchez L, García-Fuentes E, Rojo-Martínez G, Cardona F, Soriguer F, Tinahones Madueño FJ. Inverse relation between levels of anti-oxidized-LDL antibodies and eicosapentanoic acid (EPA). Br. J. Nutr. 2008;100(3):585-9es
dc.identifier.issn1475-2662 (Online)-
dc.identifier.issn0007-1145 (Print)-
dc.identifier.urihttp://hdl.handle.net/10668/622-
dc.descriptionJournal Article; Research Support, Non-U.S. Gov't;es
dc.description.abstractOxidative modification of LDL is thought to play an important role in the development of atherosclerosis. Susceptibility of LDL to peroxidation may partly depend on the compositional characteristics of the antioxidant and fatty acid content. The aim of this study was to examine the association between levels of antibodies to oxidized LDL and the various serum fatty acids in women. A total of 465 women aged 18-65 years were selected randomly from the adult population census of Pizarra, a town in southern Spain. Measurement of anti-oxidized-LDL was done by ELISA and the fatty acid composition of serum phospholipids was determined by GC. The levels of anti-oxidized-LDL antibodies were significantly related with age (r - 0.341, P < 0.001), BMI (r - 0.239, P < 0.001), waist:hip ratio (r - 0.285, P < 0.001), glucose (r - 0.208, P < 0.001), cholesterol (r - 0.243, P < 0.001), LDL-cholesterol (r - 0.185, P = 0.002), EPA (r - 0.159, P = 0.003), DHA (r - 0.121, P = 0.026), and the sum of the serum phospholipid n-3 PUFA (r - 0.141, P = 0.009). Multiple regression analysis showed that the variables that explained the behaviour of the levels of anti-oxidized-LDL antibodies were age (P < 0.001) and the serum phospholipid EPA (P < 0.001). This study showed that the fatty acid composition of serum phospholipids, and especially the percentage of EPA, was inversely related with the levels of anti-oxidized-LDL antibodies.es
dc.description.sponsorshipThe research group belongs to the Physiopathology of Obesity and Nutrition CIBER (CB06/03/0018), CIBER Diabetes y Enfermedades metabólicas (CB07/08/0019) of the Instituto de Salud Carlos III and FIS G03/152.es
dc.language.isoenes
dc.publisherCambridge University Presses
dc.relation.ispartofThe British Journal of Nutritiones
dc.subjectoxidized low density lipoproteines
dc.subjectAntibodieses
dc.subjectAtherosclerosises
dc.subjectAnticuerposes
dc.subjectAterosclerosises
dc.subjectFactores de edades
dc.subjectAutoanticuerposes
dc.subjectÁcido Eicosapentaenoicoes
dc.subjectÁcidos Grasoses
dc.subjectÁcidos Grasos Insaturadoses
dc.subjectLipoproteínas LDLes
dc.subjectFosfolípidoses
dc.subjectAnálisis de Regresiónes
dc.subjectOxidized LDLes
dc.subjectAntibodieses
dc.subjectFatty acidses
dc.subject.meshMedical Subject Headings::Named Groups::Persons::Age Groups::Adultes
dc.subject.meshMedical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Epidemiologic Factors::Age Factorses
dc.subject.meshMedical Subject Headings::Named Groups::Persons::Age Groups::Adult::Agedes
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Blood Proteins::Immunoproteins::Immunoglobulins::Antibodies::Autoantibodieses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Lipids::Fats::Dietary Fats::Dietary Fats, Unsaturated::Fatty Acids, Omega-3::Eicosapentaenoic Acides
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acidses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids, Unsaturatedes
dc.subject.meshMedical Subject Headings::Check Tags::Femalees
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Lipids::Lipoproteins::Lipoproteins, LDLes
dc.subject.meshMedical Subject Headings::Named Groups::Persons::Age Groups::Adult::Middle Agedes
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Lipids::Phospholipidses
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Regression Analysises
dc.subject.meshMedical Subject Headings::Named Groups::Persons::Age Groups::Adult::Young Adultes
dc.subject.meshMedical Subject Headings::Named Groups::Persons::Age Groups::Adolescentes
dc.titleInverse relation between levels of anti-oxidized-LDL antibodies and eicosapentanoic acid (EPA).es
dc.typeinfo:eu-repo/semantics/articlees
dc.description.versionYeses
dc.identifier.pmid18252023-
dc.rights.accessRightsAcceso abiertoes
dc.identifier.doi10.1017/S0007114508921723-
dc.type.versioninfo:eu-repo/semantics/publishedes
dc.relation.publisherversionhttp://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=2128916es
dc.contributor.authoraffiliation[Garrido-Sánchez,L; García-Fuentes,E; Cardona,F; Tinahones Madueño,FJ] Ciber Fisiopatología, Obesidad y Nutrición (CB06/03), Instituto de Salud Carlos III, Spain. [Tinahones Madueño,FJ] Servicio de Endocrinología y Nutrición, Hospital Universitario Virgen de la Victoria, Málaga, Spain. [García-Fuentes,E; Rojo-Martínez,G; Cardona,F] Fundación IMABIS (Instituto Mediterráneo para el Avance de la Biotecnología y la Investigación Sanitaria), Málaga, Spain. [Rojo-Martínez,G; Soriguer,F] Ciber Diabetes y Enfermedades metabólicas (CB07/08/0019), Instituto de salud Carlos III, Spain. [Soriguer,F] Servicio de Endocrinología y Nutrición, Hospital Regional Universitario Carlos Haya, Málaga, Spain.es
dc.type.subtypeArtículoes
Appears in Collections:01- Artículos - Hospital Regional de Málaga
01- Artículos - Hospital Virgen de la Victoria
01- Artículos - IBIMA. Instituto de Investigación Biomédica de Málaga

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