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Title: Epigenetic approach in obesity: DNA methylation in a prepubertal population which underwent a lifestyle modification
Authors: Gallardo-Escribano, Cristina
Buonaiuto, Verónica
Ruiz-Moreno, M. Isabel
Vargas-Candela, Antonio
Vilches-Perez, Alberto
Benitez-Porres, Javier
Romance-Garcia, Angel Ramon
Ruiz-Moreno, Alejandro
Gomez-Huelgas, Ricardo
Bernal-Lopez, M. Rosa
metadata.dc.contributor.authoraffiliation: [Gallardo-Escribano,C] Clinical Analysis Department, Regional University Hospital of Malaga, Malaga, Spain. [Buonaiuto,V; Ruiz-Moreno,MI; Vargas-Candela,A; Ruiz-Moreno,A; Gomez-Huelgas,R; Bernal-Lopez,MR] Internal Medicine Department, Instituto de Investigación Biomédica de Malaga (IBIMA), Regional University Hospital of Malaga, Malaga, Spain. [Vilches-Perez,A] Endocrinology and Nutrition Department, Instituto de Investigación Biomédica de Malaga (IBIMA), University Hospital Virgen de la Victoria, Malaga, Spain. [Benitez-Porres,J] Department of Human Physiology, Physical Education and Sports. Faculty of Medicine, University of Malaga, Malaga, Spain. [Romance-Garcia,AR] Biodynamic and Body Composition Laboratory. Department of Didactics of Language, Arts, and Sport. Faculty of Education Science, University of Málaga, Malaga, Spain. [Gomez-Huelgas,R; Bernal-Lopez,MR] CIBER Patofisiología de la Obesidad y la Nutrición, Carlos III Health Institute, Madrid, Spain.
Keywords: Prepubertal population;Metabolically healthy obesity;Methylation;Lipid profile;Inflammatory profile;Lifestyle modification;Obesity;Obesidad metabólica benigna;Metilación;Obesidad;Niño;Niño preescolar;Inflamación;Lípidos;Estilo de vida saludable
metadata.dc.subject.mesh: Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Anthropometry::Body Weights and Measures::Body Mass Index
Medical Subject Headings::Diseases::Cardiovascular Diseases
Medical Subject Headings::Persons::Persons::Age Groups::Child
Medical Subject Headings::Persons::Persons::Age Groups::Child::Child, Preschool
Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Chemical Processes::Biochemical Processes::DNA Methylation
Medical Subject Headings::Diseases::Endocrine System Diseases::Diabetes Mellitus::Diabetes Mellitus, Type 2
Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet::Diet, Mediterranean
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Gene Expression Regulation::Epigenesis, Genetic
Medical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Computational Biology::Genomics::Epigenomics
Medical Subject Headings::Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Musculoskeletal Physiological Processes::Movement::Motor Activity::Exercise
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation
Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Hyperinsulinism::Insulin Resistance
Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Lipid Metabolism
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Puberty
Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Risk Reduction Behavior
Issue Date: 23-Sep-2020
Publisher: BioMed Central, Springer Nature
Citation: Gallardo-Escribano C, Buonaiuto V, Ruiz-Moreno MI, Vargas-Candela A, Vilches-Perez A, Benitez-Porres J, et al. Epigenetic approach in obesity: DNA methylation in a prepubertal population which underwent a lifestyle modification. Clin Epigenetics. 2020 Sep 23;12(1):144
Abstract: Background: Metabolically healthy obesity (MHO) is a considerably controversial concept as it is considered a transitory condition towards the development of different pathologies (type 2 diabetes, insulin resistance, or cardiovascular disease). MHO is closely related to lifestyle and environmental factors. Epigenetics has become an essential biological tool to analyze the link between obesity and metabolic status. The aim of this study was to determine whether MHO status is conditioned by the DNA methylation (DNAm) of several genes related to lipid metabolism (lipoprotein lipase, retinoid X receptor alpha, liver X receptor, stearoyl-CoA desaturase, sterol regulatory element binding factor 1), and inflammation (LEP) in peripheral blood mononuclear cells (PBMCs) from 131 prepubertal subjects with MHO phenotype after lifestyle modifications with personalized Mediterranean diet (MedDiet) combined with a physical activity (PA) program. Results: The DNAm of all studied genes were significantly modified in the population after 12 months of lifestyle modifications (MedDiet and PA). In addition, associations were found between the DNAm studies and BMI, homeostatic model assessment of insulin resistance, monounsaturated fatty acid and polyunsaturated fatty acid, moderate-vigorous PA, fat mass, and adherence to MedDiet. Conclusions: It was found that DNAm of genes related to lipid metabolism and inflammation are also present in childhood and that this methylation profile can be modified by interventions based on MedDiet and PA.
metadata.dc.identifier.doi: 10.1186/s13148-020-00935-0
ISSN: 1868-7083 (Online)
Appears in Collections:01- Artículos - Hospital Regional de Málaga
01- Artículos - Hospital Virgen de la Victoria
01- Artículos - IBIMA. Instituto de Investigación Biomédica de Málaga

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