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dc.contributor.authorAlonso-Piñeiro, Jose Angel-
dc.contributor.authorGonzalez-Rovira, Almudena-
dc.contributor.authorSánchez-Gomar, Ismael-
dc.contributor.authorMoreno, Juan Antonio-
dc.contributor.authorDurán-Ruiz, Ma Carmen-
dc.identifier.citationAlonso-Piñeiro JA, Gonzalez-Rovira A, Sánchez-Gomar I, Moreno JA, Durán-Ruiz MC. Nrf2 and Heme Oxygenase-1 Involvement in Atherosclerosis Related Oxidative Stress. Antioxidants. 2021 Sep 14;10(9):1463es_ES
dc.identifier.issn2076-3921 (Online)es_ES
dc.description.abstractAtherosclerosis remains the underlying process responsible for cardiovascular diseases and the high mortality rates associated. This chronic inflammatory disease progresses with the formation of occlusive atherosclerotic plaques over the inner walls of vascular vessels, with oxidative stress being an important element of this pathology. Oxidation of low-density lipoproteins (ox-LDL) induces endothelial dysfunction, foam cell activation, and inflammatory response, resulting in the formation of fatty streaks in the atherosclerotic wall. With this in mind, different approaches aim to reduce oxidative damage as a strategy to tackle the progression of atherosclerosis. Special attention has been paid in recent years to the transcription factor Nrf2 and its downstream-regulated protein heme oxygenase-1 (HO-1), both known to provide protection against atherosclerotic injury. In the current review, we summarize the involvement of oxidative stress in atherosclerosis, focusing on the role that these antioxidant molecules exert, as well as the potential therapeutic strategies applied to enhance their antioxidant and antiatherogenic properties.es_ES
dc.description.sponsorshipThis research was funded by the Institute of Health Carlos III, ISCIII (PI16-00784 PI17/00130,PI20/00375, and PI20-00716), Spanish Biomedical Research Center in Cardiovascular Diseases (CIBERCV), Spanish Ministry of Science and Innovation (RYC-2017-22369), Spanish Society of Nephrology (SEN), Consejería de Salud y Familias-FEDER, Junta de Andalucía (PIGE-0052-2020), and the Programa Operativo de Andalucia-FEDER, Iniciativa Territorial Integrada ITI 2014-2020, Consejería de Salud, Junta de Andalucía (PI0026-2017), co-funded by European Regional Development Fund. A way to make Europe.es_ES
dc.format.extent21 p.es_ES
dc.rightsAtribución 4.0 Internacional*
dc.subjectOxidative stresses_ES
dc.subjectHeme oxygenase-1es_ES
dc.subjectEstrés oxidativoes_ES
dc.subjectHemo-Oxigenasa 1es_ES
dc.subjectFactor 2 relacionado con NF-E2es_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::DNA-Binding Proteins::Basic-Leucine Zipper Transcription Factors::NF-E2-Related Factor 2es_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases::Oxygenases::Mixed Function Oxygenases::Heme Oxygenase (Decyclizing)::Heme Oxygenase-1es_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antioxidantses_ES
dc.subject.meshMedical Subject Headings::Anatomy::Cells::Connective Tissue Cells::Macrophages::Foam Cellses_ES
dc.subject.meshMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathological Conditions, Anatomical::Plaque, Atherosclerotices_ES
dc.subject.meshMedical Subject Headings::Diseases::Cardiovascular Diseaseses_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Lipids::Lipoproteins::Lipoproteins, LDLes_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Oxidative Stresses_ES
dc.subject.meshMedical Subject Headings::Diseases::Cardiovascular Diseases::Vascular Diseases::Arterial Occlusive Diseases::Arteriosclerosises_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses_ES
dc.titleNrf2 and Heme Oxygenase-1 Involvement in Atherosclerosis Related Oxidative Stresses_ES
dc.rights.accessRightsAcceso abiertoes_ES
dc.contributor.authoraffiliation[Alonso-Piñeiro,JA; Gonzalez-Rovira,A; Sánchez-Gomar,I; Durán-Ruiz,MC] Biomedicine, Biotechnology and Public Health Department, Cádiz University, Puerto Real, Spain. [Alonso-Piñeiro,JA; Gonzalez-Rovira,A; Sánchez-Gomar,I; Durán-Ruiz,MC] Institute of Research and Innovation in Biomedical Sciences of Cádiz (INiBICA), Cádiz, Spain. [Moreno,JA] Maimonides Biomedical Research Institute of Cordoba (IMIBIC), UGC Nephrology, Hospital Universitario Reina Sofia, Cordoba, Spain. [Moreno,JA] Department of Cell Biology, Physiology, and Immunology, Agrifood Campus of International Excellence (ceiA3), University of Cordoba, Cordoba, Spain.es_ES
Appears in Collections:01 - Artículos - INiBICA. Instituto de Investigación e Innovación Biomédica de Cádiz
01- Artículos - Hospital Reina Sofía

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