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Title: Nrf2 and Heme Oxygenase-1 Involvement in Atherosclerosis Related Oxidative Stress
Authors: Alonso-Piñeiro, Jose Angel
Gonzalez-Rovira, Almudena
Sánchez-Gomar, Ismael
Moreno, Juan Antonio
Durán-Ruiz, Ma Carmen
metadata.dc.contributor.authoraffiliation: [Alonso-Piñeiro,JA; Gonzalez-Rovira,A; Sánchez-Gomar,I; Durán-Ruiz,MC] Biomedicine, Biotechnology and Public Health Department, Cádiz University, Puerto Real, Spain. [Alonso-Piñeiro,JA; Gonzalez-Rovira,A; Sánchez-Gomar,I; Durán-Ruiz,MC] Institute of Research and Innovation in Biomedical Sciences of Cádiz (INiBICA), Cádiz, Spain. [Moreno,JA] Maimonides Biomedical Research Institute of Cordoba (IMIBIC), UGC Nephrology, Hospital Universitario Reina Sofia, Cordoba, Spain. [Moreno,JA] Department of Cell Biology, Physiology, and Immunology, Agrifood Campus of International Excellence (ceiA3), University of Cordoba, Cordoba, Spain.
Keywords: Atherosclerosis;Oxidative stress;Heme oxygenase-1;Nrf2;Aterosclerosis;Estrés oxidativo;Hemo-Oxigenasa 1;Factor 2 relacionado con NF-E2
metadata.dc.subject.mesh: Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::DNA-Binding Proteins::Basic-Leucine Zipper Transcription Factors::NF-E2-Related Factor 2
Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Oxidoreductases::Oxygenases::Mixed Function Oxygenases::Heme Oxygenase (Decyclizing)::Heme Oxygenase-1
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Antioxidants
Medical Subject Headings::Anatomy::Cells::Connective Tissue Cells::Macrophages::Foam Cells
Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathological Conditions, Anatomical::Plaque, Atherosclerotic
Medical Subject Headings::Diseases::Cardiovascular Diseases
Medical Subject Headings::Chemicals and Drugs::Lipids::Lipoproteins::Lipoproteins, LDL
Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Oxidative Stress
Medical Subject Headings::Diseases::Cardiovascular Diseases::Vascular Diseases::Arterial Occlusive Diseases::Arteriosclerosis
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Issue Date: 14-Sep-2021
Publisher: MDPI
Citation: Alonso-Piñeiro JA, Gonzalez-Rovira A, Sánchez-Gomar I, Moreno JA, Durán-Ruiz MC. Nrf2 and Heme Oxygenase-1 Involvement in Atherosclerosis Related Oxidative Stress. Antioxidants. 2021 Sep 14;10(9):1463
Abstract: Atherosclerosis remains the underlying process responsible for cardiovascular diseases and the high mortality rates associated. This chronic inflammatory disease progresses with the formation of occlusive atherosclerotic plaques over the inner walls of vascular vessels, with oxidative stress being an important element of this pathology. Oxidation of low-density lipoproteins (ox-LDL) induces endothelial dysfunction, foam cell activation, and inflammatory response, resulting in the formation of fatty streaks in the atherosclerotic wall. With this in mind, different approaches aim to reduce oxidative damage as a strategy to tackle the progression of atherosclerosis. Special attention has been paid in recent years to the transcription factor Nrf2 and its downstream-regulated protein heme oxygenase-1 (HO-1), both known to provide protection against atherosclerotic injury. In the current review, we summarize the involvement of oxidative stress in atherosclerosis, focusing on the role that these antioxidant molecules exert, as well as the potential therapeutic strategies applied to enhance their antioxidant and antiatherogenic properties.
metadata.dc.identifier.doi: 10.3390/antiox10091463
ISSN: 2076-3921 (Online)
Appears in Collections:01 - Artículos - INiBICA. Instituto de Investigación e Innovación Biomédica de Cádiz
01- Artículos - Hospital Reina Sofía

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