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Title: Factors Associated with Serum Vitamin D Metabolites and Vitamin D Metabolite Ratios in Premenopausal Women
Authors: Toribio, María José
Priego-Capote, Feliciano
Pérez-Gómez, Beatriz
Fernández de Larrea-Baz, Nerea
Ruiz-Moreno, Emma
Castelló, Adela
Lucas, Pilar
Sierra, María Ángeles
Pino, Marina Nieves
Martínez-Cortés, Mercedes
Luque de Castro, María Dolores
Lope, Virginia
Pollán, Marina
metadata.dc.contributor.authoraffiliation: [Toribio,MJ; Lope,V] Servicio de Admisión, Hospital General Universitario Gregorio Marañón, Madrid, Spain. [Toribio,MJ] Department of Preventive Medicine, Public Health and Microbiology, Universidad Autónoma de Madrid, Madrid, Spain. [Priego-Capote,F; Luque de Castro,MD] Department of Analytical Chemistry, University of Córdoba, Córdoba, Spain. [Priego-Capote,F; Luque de Castro,MD] Maimónides Institute of Biomedical Research (IMIBIC), Reina Sofia University Hospital, University of Córdoba, Córdoba, Spain. [Pérez-Gómez,B; Fernández de Larrea-Baz,N; Ruiz-Moreno,E; Lucas,P; Sierra,MÁ; Lope,V; Pollán,M] Department of Epidemiology of Chronic Diseases, National Center for Epidemiology, Carlos III Institute of Health, Madrid, Spain. [Pérez-Gómez,B; Fernández de Larrea-Baz,N; Ruiz-Moreno,E; Sierra,MÁ; Lope,V; Pollán,M] Consortium for Biomedical Research in Epidemiology & Public Health, CIBERESP, Madrid, Spain. [Castelló,A] Faculty of Medicine, University of Alcalá, Alcalá de Henares, Spain. [Pino,MN; Martínez-Cortés,M] Servicio de Prevención y Promoción de la Salud, Madrid Salud, Ayuntamiento de Madrid, Madrid, Spain.
Keywords: Vit D3;25(OH)D3;1,25(OH)2D3;24,25(OH)2D3;Vitamin D metabolite ratios;Colecalciferol;Calcifediol;Calcitriol;24,25-Dihidroxivitamina D 3;Vitamina D
metadata.dc.subject.mesh: Medical Subject Headings::Persons::Persons::Age Groups::Adult
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Persons::Persons::Age Groups::Adult::Middle Aged
Medical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Reproductive Physiological Processes::Sexual Development::Climacteric::Menopause::Premenopause
Medical Subject Headings::Chemicals and Drugs::Polycyclic Compounds::Steroids::Cholestanes::Cholestenes::Cholecalciferol::Hydroxycholecalciferols::Dihydroxycholecalciferols::24,25-Dihydroxyvitamin D 3
Medical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolome
Issue Date: 23-Oct-2021
Publisher: MDPI
Citation: Toribio MJ, Priego-Capote F, Pérez-Gómez B, Fernández de Larrea-Baz N, Ruiz-Moreno E, Castelló A, et al. Factors Associated with Serum Vitamin D Metabolites and Vitamin D Metabolite Ratios in Premenopausal Women. Nutrients. 2021 Oct 23;13(11):3747
Abstract: The most representative indicator of vitamin D status in clinical practice is 25(OH)D3, but new biomarkers could improve the assessment of vitamin D status and metabolism. The objective of this study is to investigate the association of serum vitamin D metabolites and vitamin D metabolite ratios (VMRs) with potentially influential factors in premenopausal women. This is a cross-sectional study based on 1422 women, aged 39-50, recruited from a Madrid Medical Diagnostic Center. Participants answered an epidemiological and a food frequency questionnaire. Serum vitamin D metabolites were determined using an SPE-LC-MS/MS platform. The association between participant's characteristics, vitamin D metabolites, and VMRs was quantified by multiple linear regression models. Mean 25(OH)D3 concentration was 49.2 + 18.9 nmol/L, with greater deficits among obese, nulliparous, dark-skinned women, and with less sun exposure. A lower R2 ratio (1,25(OH)2D3/25(OH)D3) and a higher R4 (24,25(OH)2D3/1,25(OH)2D3) were observed in nulliparous women, with high sun exposure, and those with low caloric intake or high consumption of calcium, vitamin D supplements, or alcohol. Nulliparous women had lower R1 (25(OH)D3/Vit D3) and R3 (24,25(OH)2D3/25(OH)D3), and older women showed lower R3 and R4. Vitamin D status modified the association of the VMRs with seasons. VMRs can be complementary indicators of vitamin D status and its endogenous metabolism, and reveal the influence of certain individual characteristics on the expression of hydroxylase enzymes.
metadata.dc.identifier.doi: 10.3390/nu13113747
ISSN: 2072-6643 (Online)
Appears in Collections:01- Artículos - Hospital Reina Sofía
01- Artículos - IMIBIC. Instituto Maimónides de Investigación Biomédica de Córdoba

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