Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/402
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dc.contributor.authorBlanco-Kelly, Fiona-
dc.contributor.authorMatesanz, Fuencisla-
dc.contributor.authorAlcina, Antonio-
dc.contributor.authorTeruel, María-
dc.contributor.authorDíaz-Gallo, Lina M.-
dc.contributor.authorGómez-García, María-
dc.contributor.authorLópez-Nevot, Miguel A.-
dc.contributor.authorRodrigo, Luis-
dc.contributor.authorNieto, Antonio-
dc.contributor.authorCardeña, Carlos-
dc.contributor.authorAlcain, Guillermo-
dc.contributor.authorDíaz-Rubio, Manuel-
dc.contributor.authorG. de la Concha, Emilio-
dc.contributor.authorFernandez, Oscar-
dc.contributor.authorArroyo, Rafael-
dc.contributor.authorMartín, Javier-
dc.contributor.authorUrcelay, Elena-
dc.date.accessioned2012-06-11T09:13:01Z-
dc.date.available2012-06-11T09:13:01Z-
dc.date.issued2010-07-12-
dc.identifier.citationBlanco-Kelly F, Matesanz F, Alcina A, Teruel M, Díaz-Gallo LM, Gómez-García M et al. CD40: Novel Association with Crohn's Disease and Replication in Multiple Sclerosis Susceptibility. PLoS One. 2010 Jul 12;5(7):e11520.es
dc.identifier.issn1932-6203 (Online)-
dc.identifier.urihttp://hdl.handle.net/10668/402-
dc.descriptionFormal Correction: This article has been formally corrected to address the following errors. The values in the first column of table 1 were published incorrectly. Please view the corrected table here:http://www.plosone.org/annotation/listThread.action?inReplyTo=6983&root=6983es
dc.description.abstractBackground: A functional polymorphism located at 21 from the start codon of the CD40 gene, rs1883832, was previously reported to disrupt a Kozak sequence essential for translation. It has been consistently associated with Graves’ disease risk in populations of different ethnicity and genetic proxies of this variant evaluated in genome-wide association studies have shown evidence of an effect in rheumatoid arthritis and multiple sclerosis (MS) susceptibility. However, the protective allele associated with Graves’ disease or rheumatoid arthritis has shown a risk role in MS, an effect that we aimed to replicate in the present work. We hypothesized that this functional polymorphism might also show an association with other complex autoimmune condition such as inflammatory bowel disease, given the CD40 overexpression previously observed in Crohn’s disease (CD) lesions. Methodology: Genotyping of rs1883832C.T was performed in 1564 MS, 1102 CD and 969 ulcerative colitis (UC) Spanish patients and in 2948 ethnically matched controls by TaqMan chemistry. Principal Findings: The observed effect of the minor allele rs1883832T was replicated in our independent Spanish MS cohort [p= 0.025; OR (95% CI)= 1.12 (1.01–1.23)]. The frequency of the minor allele was also significantly higher in CD patients than in controls [p= 0.002; OR (95% CI)= 1.19 (1.06–1.33)]. This increased predisposition was not detected in UC patients [p= 0.5; OR (95% CI)= 1.04 (0.93–1.17)]. Conclusion: The impact of CD40 rs1883832 on MS and CD risk points to a common signaling shared by these autoimmune conditionses
dc.description.sponsorshipThis work was supported by grants from: “Fundación Mutua Madrileña”, “Fundación Ramón Areces”, Junta de Andalucía-Feder P07-CVI-02551, Instituto de Salud Carlos III-Fondo Europeo de Desarrollo Regional (Feder) (PI081636, PI081676, PI070353 and RETICS-REEM RD07/0060) and Ministerio de Ciencia e Innovación-Feder (SAF2009-11491, SAF2006-00398). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.es
dc.language.isoenes
dc.publisherPublic Library of Sciencees
dc.relation.ispartofPLoS ONEes
dc.subjectAdultoes
dc.subjectAleloses
dc.subjectAntígenos CD40es
dc.subjectColitis Ulcerosaes
dc.subjectEnfermedad de Crohnes
dc.subjectFrecuencia de los Geneses
dc.subjectPredisposición Genética a la Enfermedades
dc.subjectGenotipoes
dc.subjectHumanoses
dc.subjectEsclerosis Múltiplees
dc.subjectPolimorfismo Genéticoes
dc.subject.meshMedical Subject Headings::Named Groups::Persons::Age Groups::Adultes
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Alleleses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Biological Factors::Antigens::Antigens, Surface::Antigens, Differentiation::Antigens, CD::Antigens, CD40es
dc.subject.meshMedical Subject Headings::Diseases::Digestive System Diseases::Gastrointestinal Diseases::Intestinal Diseases::Colonic Diseases::Colitis::Colitis, Ulcerativees
dc.subject.meshMedical Subject Headings::Diseases::Digestive System Diseases::Gastrointestinal Diseases::Intestinal Diseases::Inflammatory Bowel Diseases::Crohn Diseasees
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Gene Frequencyes
dc.subject.meshMedical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Disease Attributes::Disease Susceptibility::Genetic Predisposition to Diseasees
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotypees
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses
dc.subject.meshMedical Subject Headings::Diseases::Immune System Diseases::Autoimmune Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosises
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetices
dc.titleCD40: Novel Association with Crohn's Disease and Replication in Multiple Sclerosis Susceptibilityes
dc.typeinfo:eu-repo/semantics/articlees
dc.description.versionYeses
dc.identifier.pmid20634952-
dc.rights.accessRightsAcceso abiertoes
dc.identifier.doi10.1371/journal.pone.0011520-
dc.type.versioninfo:eu-repo/semantics/publishedes
dc.relation.publisherversionhttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0011520es
dc.contributor.authoraffiliation[Blanco-Kelly,F; G.de la Concha,E; Urcelay,E] Department of Clinical Immunology, Hospital Clínico San Carlos, Madrid, Spain.[Matesanz,F; Alcina,A; Teruel,M; Díaz-Gallo,LM; Martín,J] Instituto Parasitología y Biomedicina “López Neyra”, C. S. I. C., Granada, Spain. [Gómez-García,M] Servicio de Digestivo, Hospital Universitario Virgen de las Nieves, Granada, Spain. [López-Nevot,MA] Servicio de Inmunología, Hospital Universitario Virgen de las Nieves, Granada, Spain. [Rodrigo,L] Servicio de Digestivo, Hospital Universitario Central de Asturias, Oviedo, Spain. [Nieto,A] Servicio de Inmunología, Hospital Puerta del Mar, Cádiz, Spain. [Cardeña,C] Servicio de Digestivo, Hospital Clínico San Cecilio, Granada, Spain. [Alcain,G] Servicio de Digestivo, Hospital Virgen de la Victoria, Málaga, Spain. [Díaz-Rubio,M] Digestive Department, Hospital Clínico San Carlos, Madrid, Spain. [Fernandez,O] Servicio de Neurología, Instituto de Neurociencias Clínicas, Hospital Carlos Haya, Málaga, Spain. [Arroyo,R] Multiple Sclerosis Unit, Neurology Department, Hospital Clínico San Carlos, Madrid, Spain. [Arroyo,R; Urcelay,E] Members of the Red Española de Esclerosis Múltiple (REEM)es
dc.type.subtypeArtículoes
Appears in Collections:01- Artículos - Hospital Puerta del Mar
01- Artículos - Hospital Regional de Málaga
01- Artículos - Hospital San Cecilio
01- Artículos - Hospital Virgen de la Victoria
01- Artículos - Hospital Virgen de las Nieves

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