Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/3900
Title: Clinical Factors Associated with Reinfection versus Relapse in Infective Endocarditis: Prospective Cohort Study
Authors: Calderón-Parra, Jorge
Kestler, Martha
Ramos-Martínez, Antonio
Bouza, Emilio
Valerio, Maricela
de Alarcón, Arístides
Luque, Rafael
Goenaga, Miguel Ángel
Echeverría, Tomás
Fariñas, M. Carmen
Pericàs, Juan M.
Ojeda-Burgos, Guillermo
Fernández-Cruz, Ana
Plata, Antonio
Vinuesa, David
Muñoz, Patricia
metadata.dc.contributor.authoraffiliation: [Calderón-Parra,J; Ramos-Martínez,A; Fernández-Cruz,A] Unidad de Enfermedades Infecciosas, Hospital Universitario Puerta de Hierro- Majadahonda (IDIPHSA), Madrid, Spain. [Kestler,M; Bouza,E; Valerio,M; Muñoz,P] Servicio de Microbiología Clínica y Enfermedades Infecciosas, Hospital General Universitario Gregorio Marañón, Madrid, Spain. [Bouza,E; Muñoz,P] Enfermedades Respiratorias-CIBERES (CB06/06/0058), Facultad de Medicina, Universidad Complutense de Madrid, Madrid, Spain. [de Alarcón,A; Luque,R] Clinical Unit of Infectious Diseases, Microbiology and Preventive Medicine Infectious Diseases Research Group, University of Seville/CSIC/University Virgen del Rocío and Virgen Macarena (IBIS), Sevilla, Spain. [Goenaga,MÁ] Servicio de Enfermedades Infecciosas, Hospital Universitario Donostia, San Sebastián, Spain. [Echeverría,T] Servicio de Cardiología, Hospital Donosti, San Sebastián, Spain. [Fariñas,MC] Infectious Diseases Unit, Hospital Universitario Marqués de Valdecilla, University of Cantabria, Santander, Spain. [Pericàs,JM] Infectious Disease Department, Hospital Clínic de Barcelona (IDIBAPS), Barcelona, Spain. [Ojeda-Burgos,G] Unidad de Gestión Clínica de Enfermedades Infecciosas, Hospital Universitario Virgen de la Victoria, Málaga, Spain. [Plata,A] Servicio de Enfermedades Infecciosas, Hospital Regional de Málaga, Málaga, Spain. [Vinuesa,D] Servicio de Medicina Interna y Enfermedades Infecciosas, Hospital Clínico San Cecilio, Granada, Spain.
metadata.dc.contributor.group: GAMES Investigators
Keywords: Endocarditis;Bacterial;Recurrence;Enterococcus;Bacteremia;Cardiac surgical procedures;Liver disease;Recurrencia;Bacteriemia;Procedimientos quirúrgicos cardíacos;Hepatopatía;Reinfection;Reinfección;Cirrosis hepática
metadata.dc.subject.mesh: Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Diseases::Bacterial Infections and Mycoses::Infection::Cross Infection
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal Studies::Follow-Up Studies
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Patient Care::Hospitalization::Patient Discharge
Medical Subject Headings::Diseases::Cardiovascular Diseases::Heart Diseases::Endocarditis
Medical Subject Headings::Diseases::Bacterial Infections and Mycoses::Bacterial Infections::Bacteremia
Medical Subject Headings::Diseases::Digestive System Diseases::Liver Diseases
Medical Subject Headings::Organisms::Bacteria::Gram-Positive Bacteria::Lactobacillales::Enterococcaceae::Enterococcus
Medical Subject Headings::Diseases::Digestive System Diseases::Liver Diseases::Liver Cirrhosis
Issue Date: 13-Feb-2021
Publisher: MDPI
Citation: Calderón-Parra J, Kestler M, Ramos-Martínez A, Bouza E, Valerio M, de Alarcón A, et al. Clinical Factors Associated with Reinfection versus Relapse in Infective Endocarditis: Prospective Cohort Study. J Clin Med. 2021 Feb 13;10(4):748
Abstract: We aimed to identify clinical factors associated with recurrent infective endocarditis (IE) episodes. The clinical characteristics of 2816 consecutive patients with definite IE (January 2008-2018) were compared according to the development of a second episode of IE. A total of 2152 out of 2282 (94.3%) patients, who were discharged alive and followed-up for at least the first year, presented a single episode of IE, whereas 130 patients (5.7%) presented a recurrence; 70 cases (53.8%) were due to other microorganisms (reinfection), and 60 cases (46.2%) were due to the same microorganism causing the first episode. Thirty-eight patients (29.2%), whose recurrence was due to the same microorganism, were diagnosed during the first 6 months of follow-up and were considered relapses. Relapses were associated with nosocomial endocarditis (OR: 2.67 (95% CI: 1.37-5.29)), enterococci (OR: 3.01 (95% CI: 1.51-6.01)), persistent bacteremia (OR: 2.37 (95% CI: 1.05-5.36)), and surgical treatment (OR: 0.23 (0.1-0.53)). On the other hand, episodes of reinfection were more common in patients with chronic liver disease (OR: 3.1 (95% CI: 1.65-5.83)) and prosthetic endocarditis (OR: 1.71 (95% CI: 1.04-2.82)). The clinical factors associated with reinfection and relapse in patients with IE appear to be different. A better understanding of these factors would allow the development of more effective therapeutic strategies.
URI: http://hdl.handle.net/10668/3900
metadata.dc.relation.publisherversion: https://www.mdpi.com/2077-0383/10/4/748/htm
metadata.dc.identifier.doi: 10.3390/jcm10040748
ISSN: 2077-0383 (Online)
Appears in Collections:01- Artículos - Hospital Regional de Málaga
01- Artículos - Hospital San Cecilio
01- Artículos - Hospital Virgen de la Victoria
01- Artículos - Hospital Virgen del Rocío
01- Artículos - Hospital Virgen Macarena
01- Artículos - IBIS. Instituto de Biomedicina de Sevilla

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