Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/3888
Title: Treadmill Exercise Buffers Behavioral Alterations Related to Ethanol Binge-Drinking in Adolescent Mice
Authors: Sampedro-Piquero, Patricia
Millón, Carmelo
Moreno-Fernández, Román D.
García-Fernández, María
Diaz-Cabiale, Zaida
Santin, Luis Javier
metadata.dc.contributor.authoraffiliation: [Sampedro-Piquero,P; Moreno-Fernández,RD; Santin,LJ] Departamento de Psicobiología y Metodología de las Ciencias del Comportamiento, Facultad de Psicología, Universidad de Málaga, Málaga, Spain. [Sampedro-Piquero,P, Millón,C; Moreno-Fernández,RD; García-Fernández,M; Diaz-Cabiale,Z; Santin,LJ] Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain. [Millón,C; García-Fernández,M; Diaz-Cabiale,Z] Departamento de Fisiología Humana, Facultad de Medicina, Universidad de Málaga, Málaga, Spain.
Keywords: Adolescence;Aerobic exercise;Alcohol;Behavior;Drinking in the dark;Mice;Adolescente;Ejercicio físico;Etanol;Conducta;Ratones;Trastornos inducidos por alcohol
metadata.dc.subject.mesh: Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice
Medical Subject Headings::Organisms::Eukaryota::Animals
Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Central Nervous System Agents::Central Nervous System Depressants::Tranquilizing Agents::Anti-Anxiety Agents
Medical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Learning::Memory::Memory, Short-Term
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Methods::Research Design::Control Groups
Medical Subject Headings::Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Nervous System Physiological Phenomena::Nervous System Physiological Processes::Habituation, Psychophysiologic
Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Motivation
Medical Subject Headings::Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Musculoskeletal Physiological Processes::Movement::Motor Activity::Exercise
Medical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Cognition
Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Emotions
Medical Subject Headings::Chemicals and Drugs::Carbohydrates::Polysaccharides::Oligosaccharides::Disaccharides::Sucrose
Medical Subject Headings::Diseases::Chemically-Induced Disorders::Substance-Related Disorders::Alcohol-Related Disorders::Alcoholism
Medical Subject Headings::Diseases::Chemically-Induced Disorders::Substance-Related Disorders::Alcohol-Related Disorders::Alcohol-Induced Disorders
Issue Date: 20-Aug-2020
Publisher: MDPI
Citation: Sampedro-Piquero P, Millón C, Moreno-Fernández RD, García-Fernández M, Diaz-Cabiale Z, Santin LJ. Treadmill Exercise Buffers Behavioral Alterations Related to Ethanol Binge-Drinking in Adolescent Mice. Brain Sci. 2020 Aug 20;10(9):576
Abstract: The binge-drinking pattern of EtOH consumption, which is frequently observed in adolescents, is known to induce several neurobehavioral alterations, but protection strategies against these impairments remain scarcely explored. We aimed to study the protective role of treadmill physical exercise on the deficits caused after repeated cycles of binge-like EtOH exposure in the cognition, motivation, exploration, and emotion of C57BL/6J mice from adolescence to adulthood. Animals were divided into four groups: control group, exercised group, EtOH group, and exercised + EtOH group (20% in tap water). The exercise was performed for 20 min, 5 days/week at 20 cm/s. Then, animals were submitted to several behavioral tasks. Compared to binge-drinking mice, the exercised + EtOH group exhibited diminished anxiolytic-related behaviors in the elevated plus-maze, enhanced exploratory activity in the open field, reduced preference for alcohol odor when another rewarding stimulus was present (social stimulus) and lower latency to start self-cleaning behaviors in the sucrose splash test. In contrast, other measurements such as habituation learning and working memory were not improved by exercise. Besides, exercise was not able to reduce alcohol consumption across the weeks. In conclusion, physical activity during adolescence and early adulthood could buffer certain neurobehavioral alterations associated with binge-drinking, despite not reducing the quantity of consumed alcohol.
URI: http://hdl.handle.net/10668/3888
metadata.dc.relation.publisherversion: https://www.mdpi.com/2076-3425/10/9/576/htm
metadata.dc.identifier.doi: 10.3390/brainsci10090576
ISSN: 2076-3425 (Online)
Appears in Collections:01- Artículos - IBIMA. Instituto de Investigación Biomédica de Málaga

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