Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/3808
Title: Real world evidence of calcifediol or vitamin D prescription and mortality rate of COVID-19 in a retrospective cohort of hospitalized Andalusian patients
Authors: Loucera, Carlos
Peña-Chilet, María
Esteban-Medina, Marina
Muñoyerro-Muñiz, Dolores
Villegas, Román
Lopez-Miranda, Jose
Rodriguez-Baño, Jesus
Túnez, Isaac
Bouillon, Roger
Dopazo, Joaquin
Quesada Gomez, Jose Manuel
metadata.dc.contributor.authoraffiliation: [Loucera,C; Peña-Chilet,M; Esteban-Medina,M; Dopazo,J] Clinical Bioinformatics Area, Fundación Progreso y Salud (FPS), CDCA, Hospital Virgen del Rocio, Seville, Spain. [Loucera,C; Peña-Chilet,M; Esteban-Medina,M; Rodriguez-Baño,J; Dopazo,J] Institute of Biomedicine of Seville (IBIS), Hospital Virgen del Rocio, Seville, Spain. [Peña-Chilet,M; Dopazo,J] Bioinformatics in Rare Diseases (BiER), Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), FPS, Hospital Virgen del Rocio, Seville, Spain. [Muñoyerro-Muñiz,D; Villegas,R] Subdirección Técnica Asesora de Gestión de la Información, Servicio Andaluz de Salud, Seville, Spain. [Lopez-Miranda,J] Internal Medicine Department, IMIBIC/Reina Sofa University Hospital/University of Cordoba, Córdoba, Spain. [Lopez-Miranda,J] CIBER Fisiopatologia Obesidad y Nutricion (CIBEROBN), Instituto de Salud Carlos III, Madrid, Spain. [Rodriguez-Baño,J] Unidad Clínica de Enfermedades Infecciosas, Microbiología y Medicina Preventiva, Hospital Universitario Virgen Macarena, Seville, Spain. [Rodriguez-Baño,J] Departamento de Medicina, Universidad de Sevilla, Seville, Spain. [Túnez,I] Departamento de Bioquimica y Biología Molecular, Facultad de Medicina y Enfermería, Universidad de Córdoba, Córdoba, Spain. [Túnez,I; Quesada Gomez,JM] Instituto Maimónides de Investigacion Biomédica de Córdoba (IMIBIC), Córdoba, Spain. [Túnez,I] G. Técnico de Expertos de Andalucía para Estudios de Suplementos e Intervención Nutricional Frente a Covid-19, SGIDIS, Consejería de Salud y Familias, Junta de Andalucia, Seville, Spain. [Túnez,I] Secretaria General de Investigación, Desarrollo e Innovación en Salud, Consejería de Salud y Familias de la Junta de Andalucía, Seville, Spain. [Bouillon,R] Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KULeuven, Herestraat, Leuven, Belgium. [Dopazo,J] FPS/ELIXIR-ES, Fundación Progreso y Salud (FPS), CDCA, Hospital Virgen del Rocio, Seville, Spain. [Quesada Gomez,JM] CIBER de Fragilidad y Envejecimiento Saludable (CIBERFES), Hospital Universitario Reina Sofía, Universidad de Córdoba, Córdoba, Spain.
Keywords: Vitamin D;Calcifediol;Mortality;Hospitalization;Population health;COVID-19;Vitamina D;Mortalidad;Hospitalización;Salud poblacional;Andalucía
metadata.dc.subject.mesh: Medical Subject Headings::Chemicals and Drugs::Polycyclic Compounds::Steroids::Secosteroids::Vitamin D::Cholecalciferol::Hydroxycholecalciferols::Calcifediol
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Survival Analysis::Kaplan-Meier Estimate
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Case-Control Studies::Retrospective Studies
Medical Subject Headings::Geographical Locations::Geographic Locations::Europe::Spain
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Survival Analysis
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Records as Topic::Medical Records::Medical Records Systems, Computerized::Electronic Health Records
Medical Subject Headings::Geographical Locations::Geographic Locations::Europe::Spain
Medical Subject Headings::Anatomy::Endocrine System
Medical Subject Headings::Persons::Persons::Patients
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Patient Care::Hospitalization
Issue Date: 3-Dec-2021
Publisher: Springer Nature
Citation: Loucera C, Peña-Chilet M, Esteban-Medina M, Muñoyerro-Muñiz D, Villegas R, Lopez-Miranda J, et al. Real world evidence of calcifediol or vitamin D prescription and mortality rate of COVID-19 in a retrospective cohort of hospitalized Andalusian patients. Sci Rep. 2021 Dec 3;11(1):23380
Abstract: COVID-19 is a major worldwide health problem because of acute respiratory distress syndrome, and mortality. Several lines of evidence have suggested a relationship between the vitamin D endocrine system and severity of COVID-19. We present a survival study on a retrospective cohort of 15,968 patients, comprising all COVID-19 patients hospitalized in Andalusia between January and November 2020. Based on a central registry of electronic health records (the Andalusian Population Health Database, BPS), prescription of vitamin D or its metabolites within 15-30 days before hospitalization were recorded. The effect of prescription of vitamin D (metabolites) for other indication previous to the hospitalization was studied with respect to patient survival. Kaplan-Meier survival curves and hazard ratios support an association between prescription of these metabolites and patient survival. Such association was stronger for calcifediol (Hazard Ratio, HR = 0.67, with 95% confidence interval, CI, of [0.50-0.91]) than for cholecalciferol (HR = 0.75, with 95% CI of [0.61-0.91]), when prescribed 15 days prior hospitalization. Although the relation is maintained, there is a general decrease of this effect when a longer period of 30 days prior hospitalization is considered (calcifediol HR = 0.73, with 95% CI [0.57-0.95] and cholecalciferol HR = 0.88, with 95% CI [0.75, 1.03]), suggesting that association was stronger when the prescription was closer to the hospitalization.
URI: http://hdl.handle.net/10668/3808
metadata.dc.relation.publisherversion: https://www.nature.com/articles/s41598-021-02701-5
metadata.dc.identifier.doi: 10.1038/s41598-021-02701-5
ISSN: 2045-2322 (Online)
Appears in Collections:01- Artículos - Consejería de Salud y Consumo
01- Artículos - FPS. Fundación Pública Andaluza Progreso y Salud
01- Artículos - Hospital Reina Sofía
01- Artículos - Hospital Virgen del Rocío
01- Artículos - Hospital Virgen Macarena
01- Artículos - IBIS. Instituto de Biomedicina de Sevilla
01- Artículos - IMIBIC. Instituto Maimónides de Investigación Biomédica de Córdoba
01- Artículos - Servicio Andaluz de Salud

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