Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/3631
Title: Podoplanin Gene Disruption in Mice Promotes in vivo Neural Progenitor Cells Proliferation, Selectively Impairs Dentate Gyrus Synaptic Depression and Induces Anxiety-Like Behaviors
Authors: Cicvaric, Ana
Sachernegg, Hannah M.
Stojanovic, Tamara
Symmank, Dörte
Smani, Tarik
Moeslinger, Thomas
Uhrin, Pavel
Monje, Francisco J.
metadata.dc.contributor.authoraffiliation: [Cicvaric,A; Sachernegg,HM; Stojanovic,T, Monje,FJ] Center for Physiology and Pharmacology, Department of Neurophysiology and Neuropharmacology, Medical University of Vienna, Vienna, Austria. [Symmank,D; Moeslinger,T] Center for Physiology and Pharmacology, Institute for Physiology, Medical University of Vienna, Vienna, Austria. [Smani,T] Department of Medical Physiology and Biophysics, Institute of Biomedicine of Seville (IBiS)/University of Seville/CIBERCV, Seville, Spain. [Uhrin,P] Center for Physiology and Pharmacology, Department of Vascular Biology and Thrombosis Research, Medical University of Vienna, Vienna, Austria
Keywords: Neurogenesis;Podoplanin;LTD;Anxiety-like behavior;NGF;Cell proliferation;The hippocampus;Neurogénesis;Depresión sináptica a largo plazo;Ansiedad;Factor de crecimiento nervioso;Proliferación celular;Hipocampo
metadata.dc.subject.mesh: Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Differentiation::Neurogenesis
Medical Subject Headings::Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Nervous System Physiological Phenomena::Nervous System Physiological Processes::Neuronal Plasticity::Long-Term Synaptic Depression
Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Emotions::Anxiety
Medical Subject Headings::Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins::Nerve Growth Factors
Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Growth Processes::Cell Proliferation
Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain::Limbic System::Hippocampus
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice
Medical Subject Headings::Organisms::Eukaryota::Animals
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Behavioral Symptoms::Depression
Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain::Limbic System::Hippocampus::Dentate Gyrus
Medical Subject Headings::Anatomy::Nervous System::Synapses
Medical Subject Headings::Anatomy::Cells::Neurons
Medical Subject Headings::Psychiatry and Psychology::Mental Disorders::Anxiety Disorders
Medical Subject Headings::Anatomy::Cells::Stem Cells
Issue Date: 15-Jan-2020
Publisher: Frontiers
Citation: Cicvaric A, Sachernegg HM, Stojanovic T, Symmank D, Smani T, Moeslinger T, et al. Podoplanin Gene Disruption in Mice Promotes in vivo Neural Progenitor Cells Proliferation, Selectively Impairs Dentate Gyrus Synaptic Depression and Induces Anxiety-Like Behaviors. Front Cell Neurosci. 2020 Jan 15;13:561
Abstract: Podoplanin (Pdpn), a brain-tumor-related glycoprotein identified in humans and animals, is endogenously expressed in several organs critical for life support such as kidney, lung, heart and brain. In the brain, Pdpn has been identified in proliferative nestin-positive adult neural progenitor cells and in neurons of the neurogenic hippocampal dentate gyrus (DG), a structure associated to anxiety, critical for learning and memory functions and severely damaged in people with Alzheimer's Disease (AD). The in vivo role of Pdpn in adult neurogenesis and anxiety-like behavior remained however unexplored. Using mice with disrupted Pdpn gene as a model organism and applying combined behavioral, molecular biological and electrophysiological assays, we here show that the absence of Pdpn selectively impairs long-term synaptic depression in the neurogenic DG without affecting the CA3-Schaffer's collateral-CA1 synapses. Pdpn deletion also enhanced the proliferative capacity of DG neural progenitor cells and diminished survival of differentiated neuronal cells in vitro. In addition, mice with podoplanin gene disruption showed increased anxiety-like behaviors in experimentally validated behavioral tests as compared to wild type littermate controls. Together, these findings broaden our knowledge on the molecular mechanisms influencing hippocampal synaptic plasticity and neurogenesis in vivo and reveal Pdpn as a novel molecular target for future studies addressing general anxiety disorder and synaptic depression-related memory dysfunctions.
URI: http://hdl.handle.net/10668/3631
metadata.dc.relation.publisherversion: https://www.frontiersin.org/articles/10.3389/fncel.2019.00561/full
metadata.dc.identifier.doi: 10.3389/fncel.2019.00561
ISSN: 1662-5102 (Online)
Appears in Collections:01- Artículos - IBIS. Instituto de Biomedicina de Sevilla

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