Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/2667
Title: Knee Viscosupplementation: Cost-Effectiveness Analysis between Stabilized Hyaluronic Acid in a Single Injection versus Five Injections of Standard Hyaluronic Acid
Authors: Estades-Rubio, Francisco J
Reyes-Martín, Alvaro
Morales-Marcos, Victor
García-Piriz, Mercedes
García-Vera, Juan J
Perán, Macarena
Marchal, Juan A
Montañez-Heredia, Elvira
metadata.dc.contributor.authoraffiliation: [Estades-Rubio, JF; García-Piriz,M; García-Vera,J; Montañez-Heredia,E] Department of Orthopedic Surgery and Traumatology, Virgen de la Victoria University Hospital, Málaga, Spain. [Reyes-Martín,A] Department of Orthopedic Surgery and Traumatology, Hospital Regional Universitario Carlos Haya, Malaga, Málaga, Spain. [Morales-Marcos,V] Department of Orthopedic Surgery and Traumatology, Hospital Quirónsalud Málaga, Málaga, Spain. [Perán,M] Department of Health Sciences, University of Jaén, Jaén, Spain. [Perán,M; Marchal,JA] Biopathology and Regenerative Medicine Institute (IBIMER), Centre for Biomedical Research, University of Granada, Granada, Spain. [Marchal,JA] Department of Human Anatomy and Embryology, Faculty of Medicine, University of Granada, Granada, Spain. Biosanitary Institute of Granada (ibs. GRANADA), University Hospitals of Granada-University of Granada, Granada, Granada, Spain. [Montañez-Heredia,E] Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain.
Keywords: Knee osteoarthritis;Hyalunonic acid;Stabilized hyaluronic acid (NASHA);Inyecciones intraarticulares;Masculino;Mediana edad;Osteoartritis de la rodilla;Distribución aleatoria;Viscosuplementación;Costos de la atención en salud;Adulto;Anciano;Femenino;Humanos;Ácido hialurónico
metadata.dc.subject.mesh: Medical Subject Headings::Persons::Persons::Age Groups::Adult
Medical Subject Headings::Persons::Persons::Age Groups::Adult::Aged
Medical Subject Headings::Check Tags::Female
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Chemicals and Drugs::Carbohydrates::Polysaccharides::Glycosaminoglycans::Hyaluronic Acid
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Drug Administration Routes::Injections::Injections, Intra-Articular
Medical Subject Headings::Check Tags::Male
Medical Subject Headings::Persons::Persons::Age Groups::Adult::Middle Aged
Medical Subject Headings::Diseases::Musculoskeletal Diseases::Joint Diseases::Arthritis::Osteoarthritis::Osteoarthritis, Knee
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Methods::Research Design::Random Allocation
Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Therapeutics::Drug Therapy::Drug Administration Routes::Injections::Injections, Intra-Articular::Viscosupplementation
Medical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Delivery of Health Care::Health Care Costs
Issue Date: 17-Mar-2017
Publisher: MDPI
Citation: Estades-Rubio FJ, Reyes-Martín A, Morales-Marcos V, García-Piriz M, García-Vera JJ, Perán M, et al.Knee Viscosupplementation: Cost-Effectiveness Analysis between Stabilized Hyaluronic Acid in a Single Injection versus Five Injections of Standard Hyaluronic Acid. Int J Mol Sci. 2017; 18(3).
Abstract: Given the wide difference in price per vial between various presentations of hyaluronic acid, this study seeks to compare the effectiveness and treatment cost of stabilized hyaluronic acid (NASHA) in a single injection with standard preparations of hyaluronic acid (HA) in five injections in osteoarthritis (OA) of the knee. Fifty-four patients with knee osteoarthritis (Kellgren-Lawrence Grade II and III) and the Western Ontario and McMaster Universities Arthritis Index (WOMAC) pain score greater than 7, with a homogeneous distribution of age, sex, BMI, and duration of disease, were included in this study. Patients were randomized into two groups: Group I was treated with NASHA (Durolane(®)) and Group II with HA (Go-ON(®)). Patient's evolution was followed up at the 1st, 2nd, 4th, 8th, 12th, and 26th week after treatment. A statistically significant improvement in WOMAC score was observed for patients treated with NASHA versus those who received HA at Week 26. In addition, the need for analgesia was significantly reduced at Week 26 in the NASHA-treated group. Finally, the economic analysis showed an increased cost of overall treatment with HA injections. Our data support the use of the NASHA class of products in the treatment of knee OA.
URI: http://hdl.handle.net/10668/2667
metadata.dc.relation.publisherversion: http://www.mdpi.com/1422-0067/18/3/658
metadata.dc.identifier.doi: 10.3390/ijms18030658
ISSN: 1422-0067 (Online)
Appears in Collections:01- Artículos - Hospital Regional de Málaga
01- Artículos - Hospital Virgen de la Victoria
01- Artículos - IBIMA. Instituto de Investigación Biomédica de Málaga
01- Artículos - ibsGRANADA. Instituto de Investigación Biosanitaria de Granada

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