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dc.contributor.authorDe-Ugarte, Laura-
dc.contributor.authorCaro-Molina, Enrique-
dc.contributor.authorRodríguez-Sanz, Maria-
dc.contributor.authorGarcía-Pérez, Miguel Angel-
dc.contributor.authorOlmos, José M-
dc.contributor.authorSosa-Henríquez, Manuel-
dc.contributor.authorPérez-Cano, Ramón-
dc.contributor.authorGómez-Alonso, Carlos-
dc.contributor.authorDel Rio, Luis-
dc.contributor.authorMateo-Agudo, Jesús-
dc.contributor.authorBlázquez-Cabrera, José Antonio-
dc.contributor.authorGonzález-Macías, Jesús-
dc.contributor.authorDel Pino-Montes, Javier-
dc.contributor.authorMuñoz-Torres, Manuel-
dc.contributor.authorDiaz-Curiel, Manuel-
dc.contributor.authorMalouf, Jorge-
dc.contributor.authorCano, Antonio-
dc.contributor.authorPérez-Castrillon, José Luis-
dc.contributor.authorNogues, Xavier-
dc.contributor.authorGarcia-Giralt, Natalia-
dc.contributor.authorDiez-Perez, Adolfo-
dc.identifier.citationDe-Ugarte L, Caro-Molina E, Rodríguez-Sanz M, García-Pérez MA, Olmos JM, Sosa-Henríquez M et al.SNPs in bone-related miRNAs are associated with the osteoporotic phenotype. Sci Rep. 2017 Mar 31;7(1):516.es_ES
dc.identifier.issn2045-2322 (Online)es_ES
dc.description.abstractBiogenesis and function of microRNAs can be influenced by genetic variants in the pri-miRNA sequences leading to phenotypic variability. This study aims to identify single nucleotide polymorphisms (SNPs) affecting the expression levels of bone-related mature microRNAs and thus, triggering an osteoporotic phenotype. An association analysis of SNPs located in pri-miRNA sequences with bone mineral density (BMD) was performed in the OSTEOMED2 cohort (n = 2183). Functional studies were performed for assessing the role of BMD-associated miRNAs in bone cells. Two SNPs, rs6430498 in the miR-3679 and rs12512664 in the miR-4274, were significantly associated with femoral neck BMD. Further, we measured these BMD-associated microRNAs in trabecular bone from osteoporotic hip fractures comparing to non-osteoporotic bone by qPCR. Both microRNAs were found overexpressed in fractured bone. Increased matrix mineralization was observed after miR-3679-3p inhibition in human osteoblastic cells. Finally, genotypes of rs6430498 and rs12512664 were correlated with expression levels of miR-3679 and miR-4274, respectively, in osteoblasts. In both cases, the allele that generated higher microRNA expression levels was associated with lower BMD values. In conclusion, two osteoblast-expressed microRNAs, miR-3679 and miR-4274, were associated with BMD; their overexpression could contribute to the osteoporotic phenotype. These findings open new areas for the study of bone disorders.es_ES
dc.description.sponsorshipThis work was supported by RETICEF (RD12/0043/0022), CIBERFES (CB16/10/00245) and the Grant FIS PI10/01537, PI12/02775, PI12/02582, and PI13/00116 (Carlos III Health Institute, Science and Innovation Ministry); FIS and Grants from the Generalitat de Catalunya (DIUE 2014 SGR 775), “664367/FOCUS” project (EU Health Programme; 2014–2020) and FEDER funds have supported this study.es_ES
dc.publisherNature Publishing Groupes_ES
dc.relation.ispartofScientific Reportses_ES
dc.subjectDensidad óseaes_ES
dc.subjectEnfermedades óseases_ES
dc.subjectCuello femorales_ES
dc.subjectFracturas de caderaes_ES
dc.subjectFracturas osteoporóticases_ES
dc.subjectPolimorfismo de nucleótido simplees_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Structures::Genome::Genome Components::Genes::Alleleses_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Bone Densityes_ES
dc.subject.meshMedical Subject Headings::Diseases::Musculoskeletal Diseases::Bone Diseaseses_ES
dc.subject.meshCancellous Bonees_ES
dc.subject.meshMedical Subject Headings::Anatomy::Musculoskeletal System::Skeleton::Bone and Bones::Bones of Lower Extremity::Leg Bones::Femur::Femur Neckes_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotypees_ES
dc.subject.meshMedical Subject Headings::Diseases::Wounds and Injuries::Fractures, Bone::Hip Fractureses_ES
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses_ES
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Antisense Elements (Genetics)::RNA, Antisense::MicroRNAses_ES
dc.subject.meshMedical Subject Headings::Anatomy::Cells::Connective Tissue Cells::Osteoblastses_ES
dc.subject.meshMedical Subject Headings::Diseases::Wounds and Injuries::Fractures, Bone::Osteoporotic Fractureses_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Phenotypees_ES
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism, Single Nucleotidees_ES
dc.subject.meshMedical Subject Headings::Anatomy::Musculoskeletal System::Skeleton::Bone and Bones::Cancellous Bonees_ES
dc.titleSNPs in bone-related miRNAs are associated with the osteoporotic phenotypees_ES
dc.rights.accessRightsAcceso abiertoes_ES
dc.contributor.authoraffiliation[De-Ugarte,L; Caro-Molina,E; Rodríguez-Sanz,M; Nogues,X; Garcia-Giralt,N; Diez-Perez,A] IMIM (Hospital del Mar Medical Research Institute), Universitat Autònoma de Barcelona, CIBERFES, RETICEF (ISCIII), Barcelona, Spain. [García-Pérez,MA] Department of Genetics and Institute of Health Research INCLIVA, University of Valencia, Valencia, Spain. [Olmos,JM] Department of Internal Medicine, Hospital Universitario Marqués de Valdecilla-IDIVAL/Hospital de Torrelavega, Universidad de Cantabria. RETICEF, Santander, Spain. [Sosa-Henríquez,M] Unidad Metabólica Ósea, Hospital Universitario Insular, Universidad de Las Palmas de Gran Canaria, Canarias, Spain. [Pérez-Cano,R] Departamento de Medicina (USE), UGC Medicina Interna, Hospital Universitario Virgen Macarena, Seville, Spain. [ Gómez-Alonso,C] Servicio de Metabolismo Óseo y Mineral, Hospital Universitario Central de Asturias, Oviedo, Spain. [Del Rio,L] CETIR Grup Mèdic, RETICEF, Barcelona, Spain. [Mateo-Agudo,J] Servicio COT, Hospital Universitario Miguel Servet, Zaragoza, Spain. [Blázquez-Cabrera,JA] Servicio de Medicina Interna, Complejo Hospitalario Universitario de Albacete, Albacete, Spain. [González-Macías,J] Departamento de Medicina Interna, H. Marqués de Valdecilla, Universidad de Cantabria, IDIVAL, RETICEF, Santander, Spain. [del Pino-Montes,J] Servicio de Reumatología. Hospital Universitario de Salamanca, RETICEF (ISCIII), IBSAL (Biomedical Research Institute of Salamanca), Salamanca, Spain. [Muñoz-Torres,M] UGC Endocrinologia y Nutrición. Hospital Universitario San Cecilio. Granada, RETICEF, Ibs, Granada, Spain. [Diaz-Curiel,M] Unidad de Enfermedades Metabólicas Óseas. Servicio de Medicina Interna. Fundacion Jimenez Diaz, Madrid, Spain. [Malouf,J] Hospital de la Santa Creu I Sant Pau. Institut d’Investigació Biomèdica Sant Pau, Barcelona, Spain. [Cano,A] Department of Pediatrics, Obstetrics and Gynecology, University of Valencia, INCLIVA, Valencia, Spain. [Pérez-Castrillon,JL] Hospital Universitario Río Hortega, Valladolid, Spain.es_ES
Appears in Collections:01- Artículos - Complejo Hospitalario Universitario de Granada
01- Artículos - Hospital Virgen Macarena
01- Artículos - ibsGRANADA. Instituto de Investigación Biosanitaria de Granada

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