Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/2339
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dc.contributor.authorRivera, Patricia-
dc.contributor.authorBlanco, Eduardo-
dc.contributor.authorBindila, Laura-
dc.contributor.authorAlen, Francisco-
dc.contributor.authorVargas, Antonio-
dc.contributor.authorRubio, Leticia-
dc.contributor.authorPavón, Francisco J-
dc.contributor.authorSerrano, Antonia-
dc.contributor.authorLutz, Beat-
dc.contributor.authorRodríguez de Fonseca, Fernando-
dc.contributor.authorSuárez, Juan-
dc.date.accessioned2016-08-09T10:15:10Z-
dc.date.available2016-08-09T10:15:10Z-
dc.date.issued2015-09-29-
dc.identifier.citationRivera P, Blanco E, Bindila L, Alen F, Vargas A, Rubio L, et al. Pharmacological activation of CB2 receptors counteracts the deleterious effect of ethanol on cell proliferation in the main neurogenic zones of the adult rat brain. Front Cell Neurosci. 2015; 9:379es
dc.identifier.issn1662-5102 (Online)-
dc.identifier.otherPMC4587308-
dc.identifier.urihttp://hdl.handle.net/10668/2339-
dc.descriptionJournal Article;es
dc.description.abstractChronic alcohol exposure reduces endocannabinoid activity and disrupts adult neurogenesis in rodents, which results in structural and functional alterations. Cannabinoid receptor agonists promote adult neural progenitor cell (NPC) proliferation. We evaluated the protective effects of the selective CB1 receptor agonist ACEA, the selective CB2 receptor agonist JWH133 and the fatty-acid amide-hydrolase (FAAH) inhibitor URB597, which enhances endocannabinoid receptor activity, on NPC proliferation in rats with forced consumption of ethanol (10%) or sucrose liquid diets for 2 weeks. We performed immunohistochemical and stereological analyses of cells expressing the mitotic phosphorylation of histone-3 (phospho-H3+) and the replicating cell DNA marker 5-bromo-2'-deoxyuridine (BrdU+) in the main neurogenic zones of adult brain: subgranular zone of dentate gyrus (SGZ), subventricular zone of lateral ventricles (SVZ) and hypothalamus. Animals were allowed ad libitum ethanol intake (7.3 ± 1.1 g/kg/day) after a controlled isocaloric pair-feeding period of sucrose and alcoholic diets. Alcohol intake reduced the number of BrdU+ cells in SGZ, SVZ, and hypothalamus. The treatments (URB597, ACEA, JWH133) exerted a differential increase in alcohol consumption over time, but JWH133 specifically counteracted the deleterious effect of ethanol on NPC proliferation in the SVZ and SGZ, and ACEA reversed this effect in the SGZ only. JWH133 also induced an increased number of BrdU+ cells expressing neuron-specific β3-tubulin in the SVZ and SGZ. These results indicated that the specific activation of CB2 receptors rescued alcohol-induced impaired NPC proliferation, which is a potential clinical interest for the risk of neural damage in alcohol dependence.es
dc.description.sponsorshipGrant sponsor: 7th Framework Programme of European Union. Grant number: HEALTH-F2-2008-223713, REPROBESITY to FR and BL. Grant sponsor: Ministerio de Ciencia e Innovación. Grant numbers: SAF2010-19087 and SAF 2010-20521 to FR. Grant sponsor: Instituto de Salud Carlos III (ISCIII), Ministerio de Economía y Competitividad (MINECO), UE-ERDF. Grant number: CP12/03109 to JS. Grant sponsor: Red de Trastornos Adictivos, ISCIII, MINECO. Grant number: RD12/0028/0001 to FR. Grant sponsor: Plan Nacional Sobre Drogas, Ministerio de Sanidad y Consumo. Grant number: PNSD2010/143 to JS. Grant sponsor: Consejería de Economía, Innovación y Ciencia, Junta de Andalucía, UE/ERDF. Grant numbers: PI45403 and CTS-8221 to FR. Grant sponsor: Consejería de Salud, Junta de Andalucía, UE/ERDF. Grant numbers: SAS111224 to JS. Grant sponsor: German Research Foundation DFG. Grant number: FOR926, project CP to BL. JS, FP, and AS hold “Miguel Servet” research contracts from the National System of Health, ISCIII (grant numbers: CP12/03109, CP14/00212 and CP14/00173, respectively).es
dc.language.isoenes
dc.publisherFrontiers Mediaes
dc.relation.ispartofFrontiers in Cellular Neurosciencees
dc.subjectAlcoholes
dc.subjectACEAes
dc.subjectJWH133es
dc.subjectCB1 receptores
dc.subjectNeurogenesises
dc.subjectCB2 receptores
dc.subjectConsumo de alcoholes
dc.subjectAlcoholismoes
dc.subjectBenzamidases
dc.subjectbromodesoxiuridinaes
dc.subjectCarbamatoses
dc.subjectGiro dentadoes
dc.subjectDietaes
dc.subjectEndocannabinoideses
dc.subjectEtanoles
dc.subjectmarcadores genéticoses
dc.subjectHistonases
dc.subjectHidrolasases
dc.subjectHipotálamoes
dc.subjectVentrículos lateraleses
dc.subjectCélulas madre nerviosases
dc.subjectNeuronases
dc.subjectFosforilaciónes
dc.subjectRatases
dc.subjectReceptor cannabinoide CB1es
dc.subjectSacarosaes
dc.subjectTubulina (proteína)es
dc.subject.meshMedical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Drinking Behavior::Alcohol Drinkinges
dc.subject.meshMedical Subject Headings::Psychiatry and Psychology::Mental Disorders::Substance-Related Disorders::Alcohol-Related Disorders::Alcoholismes
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animalses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amides::Benzamideses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Nucleic Acids, Nucleotides, and Nucleosides::Nucleosides::Deoxyribonucleosides::Deoxyuridine::Bromodeoxyuridinees
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Organic Chemicals::Carboxylic Acids::Acids, Acyclic::Carbamateses
dc.subject.meshMedical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain::Prosencephalon::Telencephalon::Cerebrum::Cerebral Cortex::Hippocampus::Dentate Gyruses
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Dietes
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Neurotransmitter Agents::Endocannabinoidses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Organic Chemicals::Alcohols::Ethanoles
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Phenotype::Genetic Markerses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Nuclear Proteins::Histoneses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolaseses
dc.subject.meshMedical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain::Prosencephalon::Diencephalon::Hypothalamuses
dc.subject.meshMedical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain::Cerebral Ventricles::Lateral Ventricleses
dc.subject.meshMedical Subject Headings::Anatomy::Cells::Stem Cells::Neural Stem Cellses
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::Growth and Development::Morphogenesis::Embryonic and Fetal Development::Organogenesis::Neurogenesises
dc.subject.meshMedical Subject Headings::Anatomy::Nervous System::Neuronses
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Metabolic Phenomena::Metabolism::Phosphorylationes
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Ratses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, G-Protein-Coupled::Receptors, Cannabinoid::Receptor, Cannabinoid, CB1es
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, G-Protein-Coupled::Receptors, Cannabinoid::Receptor, Cannabinoid, CB2es
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Carbohydrates::Polysaccharides::Oligosaccharides::Disaccharides::Sucrosees
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Nerve Tissue Proteins::Tubulines
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Molecular Mechanisms of Pharmacological Action::Neurotransmitter Agents::Cannabinoid Receptor Modulators::Cannabinoid Receptor Agonistses
dc.titlePharmacological activation of CB2 receptors counteracts the deleterious effect of ethanol on cell proliferation in the main neurogenic zones of the adult rat brain.es
dc.typeinfo:eu-repo/semantics/articlees
dc.description.versionYeses
dc.identifier.pmid26483633-
dc.rights.accessRightsAcceso abiertoes
dc.identifier.doi10.3389/fncel.2015.00379-
dc.type.versioninfo:eu-repo/semantics/publishedes
dc.relation.publisherversionhttp://journal.frontiersin.org/article/10.3389/fncel.2015.00379/fulles
dc.contributor.authoraffiliation[Rivera,P; Blanco,E; Alen,F; Vargas,A; Pavón,FJ; Serrano,A; Rodríguez de Fonseca,F; Suárez,J[ UGC Salud Mental, Instituto de Investigación Biomédica de Málaga, Universidad de Málaga-Hospital Universitario Regional de Málaga, Málaga, Spain. [Blanco,E] Departament de Pedagogia i Psicologia, Facultat de Ciències de l'Educació, Universitat de Lleida, Lleida, Spain. [Bindila,L; Lutz,B] Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg-University of Mainz, Mainz, Germany. [Rubio,L] Departamento de Anatomía y Medicina Legal, Universidad de Málaga, Málaga, Spain.es
dc.type.subtypeArtículoes
Appears in Collections:01- Artículos - Hospital Regional de Málaga
01- Artículos - IBIMA. Instituto de Investigación Biomédica de Málaga

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