Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/2176
Title: Rheumatoid arthritis response to treatment across IgG1 allotype - anti-TNF incompatibility: a case-only study.
Authors: Montes, Ariana
Perez-Pampin, Eva
Navarro-Sarabia, Federico
Moreira, Virginia
Rodríguezde la Serna, Arturo
Magallares, Berta
Vasilopoulos, Yiannis
Sarafidou, Theologia
Fernández-Nebro, Antonio
Ordóñez, María Del Carmen
Narváez, Javier
Cañete, Juan D
Marquez, Ana
Pascual-Salcedo, Dora
Joven, Beatriz
Carreira, Patricia
Moreno-Ramos, Manuel J
Caliz, Rafael
Ferrer, Miguel Angel
Garcia-Portales, Rosa
Blanco, Francisco J
Magro, Cesar
Raya, Enrique
Valor, Lara
Alegre-Sancho, Juan J
Balsa, Alejandro
Martin, Javier
Plant, Darren
Isaacs, John
Morgan, Ann W
Barton, Anne
Wilson, Anthony G
Gómez-Reino, Juan J
Gonzalez, Antonio
metadata.dc.contributor.authoraffiliation: [Montes,A; Perez-Pampin,E] Laboratorio de Investigacion 10 and Rheumatology Unit, Instituto de Investigacion Sanitaria - Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain. [Navarro-Sarabia, F; Moreira,V] Rheumatology Unit, Hospital Universitario Virgen Macarena, Sevilla, Spain. [Rodríguez de la Serna,A; Magallares,B] Rheumatology Unit, Hospital Santa Creu e San Pau, Barcelona, Spain. [Vasilopoulos,Y; Sarafidou,T] Department of Biochemistry and Biotechnology, University of Thessaly, Larissa, Greece. [Fernández-Nebro,A; Ordóñez,MC] Servicio de Reumatología, HRU Carlos Haya, Universidad de Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), Málaga, Spain. [Narváez,J] Department of Rheumatology, Hospital Universitario de Bellvitge, Barcelona, Spain. [Cañete,Jd] Rheumatology Unit, Hospital Clinic, Barcelona, Spain. [Marquez,A] Instituto de Parasitología y Biomedicina López-Neyra, CSIC, Granada, Spain. [Pascual-Salcedo,D] Department of Immunology, Instituto de Investigación Hospital Universitario La Paz, Hospital La Paz, Madrid, Spain. [Joven,B; Carreira,P] Department of Rheumatology, Hospital 12 de Octubre, Madrid, Spain. [Moreno-Ramos,MJ] Department of Rheumatology, Hospital Virgen de la Arrixaca, Murcia, Spain. [Caliz,R; Ferrer,NA] Rheumatology Unit, Hospital Universitario Virgen de las Nieves, Granada, Spain. [Garcia-Portales,R] Department of Rheumatology, Hospital Virgen de la Victoria, Málaga, Spain. [Blanco,FJ] Rheumatology Department, Instituto de Investigacion Biomedica-Complejo Hospitalario Universitario A Coruna; Department of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain. [Magro,C; Raya,E] Department of Rheumatology, Hospital Clínico San Cecilio, Granada, Spain. [Valor,L] Rheumatology Unit, Hospital General Universitario Gregorio Marañón, Madrid, Spain. [Alegre-Sancho,JJ] Department of Rheumatology, Hospital Doctor Peset, Valencia, Spain. [Balsa,A] Department of Rheumatology, Instituto de Investigación Hospital Universitario La Paz, Hospital Universitario La Paz, Madrid, Spain.[Martin,J] Instituto de Parasitología y Biomedicina López-Neyra, CSIC, Granada, Spain. [Plant,D] NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK. [Isaacs,J] Musculoskeletal Research Group, Institute of Cellular Medicine, The Medical School, Newcastle University; National Institute for Health Research Newcastle Biomedical Research Centre, Newcastle upon Tyne Hospitals NHS Foundation Trust and Newcastle University, Newcastle upon Tyne, Newcastle, UK. [Morgan,AW] Leeds Institute of Rheumatic and Musculoskeletal Medicine, St. James's University Hospital, University of Leeds; NIHR Leeds Musculoskeletal Biomedical Research Unit, Leeds Teaching Hospitals NHS Trust, Leeds, UK. [Barton,A] NIHR Manchester Musculoskeletal Biomedical Research Unit, Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre; Arthritis Research UK-Centre for Genetics and Genomics, The University of Manchester, Manchester, UK. [Wilson,AG] University College Dublin, Dublin, Ireland. [Gómez-Reino,JJ] Laboratorio de Investigacion 10 and Rheumatology Unit, Instituto de Investigacion Sanitaria - Hospital Clinico Universitario de Santiago; Department of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain. [Gonzalez,A] Laboratorio de Investigacion 10 and Rheumatology Unit, Instituto de Investigacion Sanitaria - Hospital Clinico Universitario de Santiago; Laboratorio Investigacion 10, Hospital Clinico Universitario de Santiago, Santiago de Compostela, Spain.
Keywords: Artritis reumatoide;Genotipo;Articulaciones;Enfermedades reumáticas;Factor de necrosis tumoral alfa
metadata.dc.subject.mesh: Medical Subject Headings::Diseases::Musculoskeletal Diseases::Joint Diseases::Arthritis::Arthritis, Rheumatoid
Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genotype
Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
Medical Subject Headings::Anatomy::Musculoskeletal System::Skeleton::Joints
Medical Subject Headings::Diseases::Musculoskeletal Diseases::Rheumatic Diseases
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Monokines::Tumor Necrosis Factor-alpha
Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Intercellular Signaling Peptides and Proteins::Cytokines::Tumor Necrosis Factors
Issue Date: 18-Mar-2015
Publisher: BioMed Central
Citation: Montes A, Perez-Pampin E, Navarro-Sarabia F, Moreira V, de la Serna AR, Magallares B, et al. Rheumatoid arthritis response to treatment across IgG1 allotype - anti-TNF incompatibility: a case-only study. Arthritis Res. Ther. 2015; 17:63
Abstract: INTRODUCTION We have hypothesized that incompatibility between the G1m genotype of the patient and the G1m1 and G1m17 allotypes carried by infliximab (INX) and adalimumab (ADM) could decrease the efficacy of these anti-tumor necrosis factor (anti-TNF) antibodies in the treatment of rheumatoid arthritis (RA). METHODS The G1m genotypes were analyzed in three collections of patients with RA totaling 1037 subjects. The first, used for discovery, comprised 215 Spanish patients. The second and third were successively used for replication. They included 429 British and Greek patients and 393 Spanish and British patients, respectively. Two outcomes were considered: change in the Disease Activity Score in 28 joint (ΔDAS28) and the European League Against Rheumatism (EULAR) response criteria. RESULTS An association between less response to INX and incompatibility of the G1m1,17 allotype was found in the discovery collection at 6 months of treatment (P = 0.03). This association was confirmed in the replications (P = 0.02 and 0.08, respectively) leading to a global association (P = 0.001) that involved a mean difference in ΔDAS28 of 0.4 units between compatible and incompatible patients (2.3 ± 1.5 in compatible patients vs. 1.9 ± 1.5 in incompatible patients) and an increase in responders and decrease in non-responders according to the EULAR criteria (P = 0.03). A similar association was suggested for patients treated with ADM in the discovery collection, but it was not supported by replication. CONCLUSIONS Our results suggest that G1m1,17 allotypes are associated with response to INX and could aid improved therapeutic targeting in RA.
Description: Journal Article;
URI: http://hdl.handle.net/10668/2176
metadata.dc.relation.publisherversion: http://www.arthritis-research.com/content/17/1/63#abs
metadata.dc.identifier.doi: 10.1186/s13075-015-0571-z
ISSN: 1478-6362 (Online)
1478-6354 (Print)
Appears in Collections:01- Artículos - Hospital Regional de Málaga
01- Artículos - Hospital San Cecilio
01- Artículos - Hospital Virgen de la Victoria
01- Artículos - Hospital Virgen Macarena
01- Artículos - IBIMA. Instituto de Investigación Biomédica de Málaga

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