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http://hdl.handle.net/10668/17533| Title: | JMJD6 Is a Druggable Oxygenase That Regulates AR-V7 Expression in Prostate Cancer. |
| Authors: | Paschalis, Alec Welti, Jonathan Neeb, Antje J Yuan, Wei Figueiredo, Ines Pereira, Rita Ferreira, Ana Riisnaes, Ruth Rodrigues, Daniel Nava Jiménez-Vacas, Juan M Kim, Soojin Uo, Takuma Micco, Patrizio Di Tumber, Anthony Islam, Md Saiful Moesser, Marc A Abboud, Martine Kawamura, Akane Gurel, Bora Christova, Rossitza Gil, Veronica S Buroni, Lorenzo Crespo, Mateus Miranda, Susana Lambros, Maryou B Carreira, Suzanne Tunariu, Nina Alimonti, Andrea Al-Lazikani, Bissan Schofield, Christopher J Plymate, Stephen R Sharp, Adam de Bono, Johann S , SU2C/PCF International Prostate Cancer Dream Team |
| metadata.dc.subject.mesh: | Alternative Splicing Antineoplastic Agents Cell Line, Tumor Cohort Studies Enzyme Inhibitors Gene Expression Regulation, Neoplastic Humans Jumonji Domain-Containing Histone Demethylases Male Molecular Targeted Therapy Oxygenases Prognosis Prostatic Neoplasms, Castration-Resistant Protein Isoforms Receptors, Androgen Retrospective Studies |
| Issue Date: | 2021 |
| Abstract: | Endocrine resistance (EnR) in advanced prostate cancer is fatal. EnR can be mediated by androgen receptor (AR) splice variants, with AR splice variant 7 (AR-V7) arguably the most clinically important variant. In this study, we determined proteins key to generating AR-V7, validated our findings using clinical samples, and studied splicing regulatory mechanisms in prostate cancer models. Triangulation studies identified JMJD6 as a key regulator of AR-V7, as evidenced by its upregulation with in vitro EnR, its downregulation alongside AR-V7 by bromodomain inhibition, and its identification as a top hit of a targeted siRNA screen of spliceosome-related genes. JMJD6 protein levels increased (P |
| URI: | http://hdl.handle.net/10668/17533 |
| metadata.dc.identifier.doi: | 10.1158/0008-5472.CAN-20-1807 |
| Appears in Collections: | Producción 2020 |
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