Please use this identifier to cite or link to this item: http://hdl.handle.net/10668/1376
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dc.contributor.authorRivera, Patricia-
dc.contributor.authorPérez-Martín, Margarita-
dc.contributor.authorPavón, Francisco J-
dc.contributor.authorSerrano, Antonia-
dc.contributor.authorCrespillo, Ana-
dc.contributor.authorCifuentes, Manuel-
dc.contributor.authorLópez-Ávalos, María-Dolores-
dc.contributor.authorGrondona, Jesús M-
dc.contributor.authorVida, Margarita-
dc.contributor.authorFernández-Llebrez, Pedro-
dc.contributor.authorRodríguez de Fonseca, Fernando-
dc.contributor.authorSuárez, Juan-
dc.date.accessioned2013-11-14T10:51:56Z-
dc.date.available2013-11-14T10:51:56Z-
dc.date.issued2013-05-31-
dc.identifier.citationRivera P, Pérez-Martín M, Pavón FJ, Serrano A, Crespillo A, Cifuentes M, et al. Pharmacological administration of the isoflavone daidzein enhances cell proliferation and reduces high fat diet-induced apoptosis and gliosis in the rat hippocampus. PLoS ONE. 2013; 8(5):e64750es
dc.identifier.issn1932-6203 (Online)-
dc.identifier.otherPMC3669353-
dc.identifier.urihttp://hdl.handle.net/10668/1376-
dc.descriptionJournal Article; Research Support, Non-U.S. Gov't;es
dc.description.abstractSoy extracts have been claimed to be neuroprotective against brain insults, an effect related to the estrogenic properties of isoflavones. However, the effects of individual isoflavones on obesity-induced disruption of adult neurogenesis have not yet been analyzed. In the present study we explore the effects of pharmacological administration of daidzein, a main soy isoflavone, in cell proliferation, cell apoptosis and gliosis in the adult hippocampus of animals exposed to a very high-fat diet. Rats made obese after 12-week exposure to a standard or high-fat (HFD, 60%) diets were treated with daidzein (50 mg kg(-1)) for 13 days. Then, plasma levels of metabolites and metabolic hormones, cell proliferation in the subgranular zone of the dentate gyrus (SGZ), and immunohistochemical markers of hippocampal cell apoptosis (caspase-3), gliosis (GFAP and Iba-1), food reward factor FosB and estrogen receptor alpha (ERα) were analyzed. Treatment with daidzein reduced food/caloric intake and body weight gain in obese rats. This was associated with glucose tolerance, low levels of HDL-cholesterol, insulin, adiponectin and testosterone, and high levels of leptin and 17β-estradiol. Daidzein increased the number of phospho-histone H3 and 5-bromo-2-deoxyuridine (BrdU)-ir cells detected in the SGZ of standard diet and HFD-fed rats. Daidzein reversed the HFD-associated enhanced immunohistochemical expression of caspase-3, FosB, GFAP, Iba-1 and ERα in the hippocampus, being more prominent in the dentate gyrus. These results suggest that pharmacological treatment with isoflavones regulates metabolic alterations associated with enhancement of cell proliferation and reduction of apoptosis and gliosis in response to high-fat diet.es
dc.description.sponsorshipThis work is supported by 7th Framework Programme of European Union [grant number HEALTH-F2-2008-223713, REPROBESITY]; Ministerio de Ciencia e Innovación [grant numbers SAF2010-19087 and SAF 2010-20521]; Instituto de Salud Carlos III del Ministerio de Ciencia e Innovación, UE-ERDF, Red de Trastornos Adictivos [grant number RD06/0001/0000]; Instituto de Salud Carlos III del Ministerio de Ciencia e Innovación, UE-ERDF, CIBERobn; Consejería de Economía, Innovación y Ciencia de la Junta de Andalucía, UE/ERDF [grant number CTS-433, P07-CVI-03079 and P-11-CVI-07637]; Consejería de salud de la Junta de Andalucía [grant numbers PI0232/2008 and PI0029/2008]. JS is recipient of a ‘‘Miguel Servet’’ research contract from the National System of Health (Instituto de Salud Carlos III, grant number CP12/03109).es
dc.language.isoenes
dc.publisherPublic Library of Sciencees
dc.relation.ispartofPloS onees
dc.subjectAlimentos a base de sojaes
dc.subjectIsoflavonases
dc.subjectProliferación celulares
dc.subjectHipocampoes
dc.subjectRatases
dc.subjectAlimentación rica en grasaes
dc.subjectHormonases
dc.subject.meshMedical Subject Headings::Technology, Industry, Agriculture::Food and Beverages::Food::Vegetables::Fabaceae::Soybeans::Soy Foodses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Benzopyrans::Chromones::Flavonoids::Isoflavoneses
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Growth Processes::Cell Proliferationes
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death::Apoptosises
dc.subject.meshMedical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain::Limbic System::Hippocampuses
dc.subject.meshMedical Subject Headings::Named Groups::Persons::Age Groups::Adultes
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animalses
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Ratses
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Diet::Diet, High-Fates
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormoneses
dc.subject.meshMedical Subject Headings::Technology, Industry, Agriculture::Food and Beverages::Foodes
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Receptors, Cytoplasmic and Nuclear::Receptors, Steroid::Receptors, Estrogen::Estrogen Receptor alphaes
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Clinical Laboratory Techniques::Clinical Chemistry Tests::Blood Chemical Analysis::Glucose Tolerance Testes
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Lipoproteins::Lipoproteins, HDL::Cholesterol, HDLes
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Pancreatic Hormones::Insulinses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Adipokines::Adiponectines
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Polycyclic Compounds::Steroids::Androstanes::Androstenes::Androstenols::Testosteronees
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Peptide Hormones::Adipokines::Leptines
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Hormones, Hormone Substitutes, and Hormone Antagonists::Hormones::Gonadal Hormones::Gonadal Steroid Hormones::Estradiol Congeners::Estradioles
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 1-Ring::Pyrimidines::Pyrimidine Nucleosides::Uridine::Deoxyuridine::Bromodeoxyuridinees
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Peptide Hydrolases::Cysteine Proteases::Cysteine Endopeptidases::Caspases::Caspases, Effector::Caspase 3es
dc.subject.meshMedical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain::Limbic System::Hippocampus::Dentate Gyruses
dc.titlePharmacological administration of the isoflavone daidzein enhances cell proliferation and reduces high fat diet-induced apoptosis and gliosis in the rat hippocampus.es
dc.typeinfo:eu-repo/semantics/articlees
dc.description.versionYeses
dc.identifier.pmid23741384-
dc.rights.accessRightsAcceso abiertoes
dc.identifier.doi10.1371/journal.pone.0064750-
dc.type.versioninfo:eu-repo/semantics/publishedes
dc.relation.publisherversionhttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0064750es
dc.contributor.authoraffiliation[Rivera,P; Pavón, FJ; Serrano,A; Crespillo,A; Vida, M; Rodríguez de Fonseca,F; Suárez,J] Laboratorio de Medicina Regenerativa (UGC Salud Mental), Instituto de Investigación Biomédica (IBIMA), Complejo Hospitalario de Málaga (Hospital Carlos Haya), Pabellón de Gobierno, Málaga, Spain. CIBER OBN, Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación, Madrid, Spain. [Pérez-Martin, M; Cifuentes,M; López-Ávalos,MD; Grondona,JM; Fernández-Llebrez,P] Departamento de Biología Celular, Genética y Fisiología, Facultad de Ciencias, Universidad de Málaga, Málaga, Spain. [Cifuentes,M] CIBER BBN, Instituto de Salud Carlos III, Ministerio de Ciencia e Innovación, Madrid, Spain.es
dc.type.subtypeArtículoes
Appears in Collections:01- Artículos - Hospital Regional de Málaga

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