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Title: | 18FDG PET/CT & arterial inflammation: predicting cardiovascular events in lung cancer. |
Authors: | Villena García, A C Cardo, A Gutierrez Hidalgo, C M Palomo, L Lillo, E Espíldora, J Trigo, J Manuel Chaparro, M Á Sánchez Valdivielso, P |
metadata.dc.subject.mesh: | Aged Aorta, Abdominal Aorta, Thoracic Arteritis Atherosclerosis Calcinosis Cardiovascular Diseases Female Fluorodeoxyglucose F18 Humans Lung Neoplasms Male Middle Aged Positron Emission Tomography Computed Tomography Proportional Hazards Models Retrospective Studies Risk Factors |
Issue Date: | 2019 |
Abstract: | 18F-FDG PET/CT predicts cardiovascular disease. To analyze the predictive value of cardiovascular events from inflammation and arterial calcification in patients who underwent an 18F-FDG PET/CT for lung cancer. A retrospective study of 274 patients with primary lung neoplasia. We determined: (i) TBR (target-to-background ratio), and (ii) the calcium score, at eight common arterial segments. We took as arteriosclerosis, a TBR ≥1.6 and ≥15 Calcium Score sum. We registered cardiovascular risk factors, comorbidities, histology, stage, treatment, status at the last clinical review, cause of death and cardiovascular event during the follow-up. The territory presenting the greatest uptake of 18F-FDG, was the thoracic aorta with an average of 1.77 (± 0.27 TBR) in the aortic arch, while the greatest degree of calcification was obtained in the abdominal aorta (52% with a Calcium Score ≥ 3). 24% of the patients presented a sum Calcium Score ≥15, and 17% a TBR ≥1.6. Patients with high TBR, (17%), had not a higher frequency of cardiovascular comorbidities beforehand, nor did they in the follow-up. However, those with a sum Calcium Score ≥15 (24%), were older, had more cardiovascular risk factors and ischemic events during follow-up. The calcium score, but not the TBR, predicted the emergence of a cardiovascular event (HR 4.9 IC95% 2.1-9.1, P In our cohort, a high Calcium Score was an independent predictor for developing cardiovascular events. |
URI: | http://hdl.handle.net/10668/13506 |
metadata.dc.identifier.doi: | 10.1093/qjmed/hcz036 |
Appears in Collections: | Producción 2020 |
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