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Title: 18FDG PET/CT & arterial inflammation: predicting cardiovascular events in lung cancer.
Authors: Villena García, A C
Cardo, A Gutierrez
Hidalgo, C M
Palomo, L
Lillo, E
Espíldora, J
Trigo, J Manuel
Chaparro, M Á Sánchez
Valdivielso, P
metadata.dc.subject.mesh: Aged
Aorta, Abdominal
Aorta, Thoracic
Cardiovascular Diseases
Fluorodeoxyglucose F18
Lung Neoplasms
Middle Aged
Positron Emission Tomography Computed Tomography
Proportional Hazards Models
Retrospective Studies
Risk Factors
Issue Date: 2019
Abstract: 18F-FDG PET/CT predicts cardiovascular disease. To analyze the predictive value of cardiovascular events from inflammation and arterial calcification in patients who underwent an 18F-FDG PET/CT for lung cancer. A retrospective study of 274 patients with primary lung neoplasia. We determined: (i) TBR (target-to-background ratio), and (ii) the calcium score, at eight common arterial segments. We took as arteriosclerosis, a TBR ≥1.6 and ≥15 Calcium Score sum. We registered cardiovascular risk factors, comorbidities, histology, stage, treatment, status at the last clinical review, cause of death and cardiovascular event during the follow-up. The territory presenting the greatest uptake of 18F-FDG, was the thoracic aorta with an average of 1.77 (± 0.27 TBR) in the aortic arch, while the greatest degree of calcification was obtained in the abdominal aorta (52% with a Calcium Score ≥ 3). 24% of the patients presented a sum Calcium Score ≥15, and 17% a TBR ≥1.6. Patients with high TBR, (17%), had not a higher frequency of cardiovascular comorbidities beforehand, nor did they in the follow-up. However, those with a sum Calcium Score ≥15 (24%), were older, had more cardiovascular risk factors and ischemic events during follow-up. The calcium score, but not the TBR, predicted the emergence of a cardiovascular event (HR 4.9 IC95% 2.1-9.1, P In our cohort, a high Calcium Score was an independent predictor for developing cardiovascular events.
metadata.dc.identifier.doi: 10.1093/qjmed/hcz036
Appears in Collections:Producción 2020

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