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Title: | mTOR Expression in Liver Transplant Candidates with Hepatocellular Carcinoma: Impact on Histological Features and Tumour Recurrence. |
Authors: | Guerrero, Marta Ferrín, Gustavo Rodríguez-Perálvarez, Manuel González-Rubio, Sandra Sánchez-Frías, Marina Amado, Víctor Pozo, Juan C Poyato, Antonio Ciria, Rubén Ayllón, María D Barrera, Pilar Montero, José L de la Mata, Manuel |
Keywords: | hepatocellular carcinoma;immunosuppression;liver transplantation;mTOR |
metadata.dc.subject.mesh: | Carcinoma, Hepatocellular Female Humans Kaplan-Meier Estimate Liver Neoplasms Liver Transplantation Male Middle Aged Multivariate Analysis Neoplasm Recurrence, Local Phosphorylation Proportional Hazards Models ROC Curve Signal Transduction TOR Serine-Threonine Kinases |
Issue Date: | 15-Jan-2019 |
Abstract: | (1) Background: The mammalian target of rapamycin (mTOR) pathway activation is critical for hepatocellular carcinoma (HCC) progression. We aimed to evaluate the mTOR tissue expression in liver transplant (LT) patients and to analyse its influence on post-LT outcomes. (2) Methods: Prospective study including a cohort of HCC patients who underwent LT (2012⁻2015). MTOR pathway expression was evaluated in the explanted liver by using the "PathScan Intracellular Signalling Array Kit" (Cell Signalling). Kaplan-Meier and Cox regression analyses were performed to evaluate post-LT HCC recurrence. (3) Results: Forty-nine patients were included (average age 56.4 ± 6, 14.3% females). Phospho-mTOR (Ser2448) was over-expressed in peritumoral tissue as compared with tumoral tissue (ΔSignal 22.2%; p |
URI: | http://hdl.handle.net/10668/13429 |
metadata.dc.identifier.doi: | 10.3390/ijms20020336 |
Appears in Collections: | Producción 2020 |
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PMC6359509.pdf | 3,07 MB | Adobe PDF | View/Open |
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