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Title: Results from the European Prospective Investigation into Cancer and Nutrition Link Vitamin B6 Catabolism and Lung Cancer Risk.
Authors: Zuo, Hui
Ueland, Per M
Midttun, Øivind
Vollset, Stein E
Tell, Grethe S
Theofylaktopoulou, Despoina
Travis, Ruth C
Boutron-Ruault, Marie-Christine
Fournier, Agnès
Severi, Gianluca
Kvaskoff, Marina
Boeing, Heiner
Bergmann, Manuela M
Fortner, Renée T
Kaaks, Rudolf
Trichopoulou, Antonia
Kotanidou, Anastasia
Lagiou, Pagona
Palli, Domenico
Sieri, Sabina
Panico, Salvatore
Bueno-de-Mesquita, H Bas
Peeters, Petra H
Grankvist, Kjell
Johansson, Mikael
Agudo, Antonio
Garcia, Jose Ramon Quiros
Larranaga, Nerea
Sanchez, Maria-Jose
Chirlaque, Maria Dolores
Ardanaz, Eva
Chuang, Shu-Chun
Gallo, Valentina
Brennan, Paul
Johansson, Mattias
Ulvik, Arve
metadata.dc.subject.mesh: Adult
Case-Control Studies
Lung Neoplasms
Middle Aged
Prospective Studies
Pyridoxal Phosphate
Pyridoxic Acid
Risk Factors
Vitamin B 6
Issue Date: 25-Oct-2017
Abstract: Circulating pyridoxal-5'-phosphate (PLP) has been linked to lung cancer risk. The PAr index, defined as the ratio 4-pyridoxic acid/(pyridoxal + PLP), reflects increased vitamin B6 catabolism during inflammation. PAr has been defined as a marker of lung cancer risk in a prospective cohort study, but analysis of a larger numbers of cases are needed to deepen the significance of this study. Here, we conducted a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC, n = 521,330), which included 892 incident lung cancer cases and 1,748 controls matched by center, gender, date of blood collection, and date of birth. The association of PAr with risk of lung cancer was evaluated by using conditional logistic regression. Study participants with elevated PAr experienced higher risk of lung cancer in a dose-response fashion, with a doubling in PAr levels associated with 52% higher odds of lung cancer after adjustment for tobacco smoking, serum cotinine levels, educational attainment, and BMI [OR, 1.52; 95% confidence interval (CI) 1.27-1.81; P
metadata.dc.identifier.doi: 10.1158/0008-5472.CAN-17-1923
Appears in Collections:Producción 2020

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