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Characterization of Metabolomic Profile Associated with Metabolic Improvement after Bariatric Surgery in Subjects with Morbid Obesity.

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dc.contributor.authorPalau-Rodriguez, Magali
dc.contributor.authorTulipani, Sara
dc.contributor.authorMarco-Ramell, Anna
dc.contributor.authorMiñarro, Antonio
dc.contributor.authorJauregui, Olga
dc.contributor.authorGonzalez-Dominguez, Raul
dc.contributor.authorSanchez-Pla, Alex
dc.contributor.authorRamos-Molina, Bruno
dc.contributor.authorTinahones, Francisco J
dc.contributor.authorAndres-Lacueva, Cristina
dc.date.accessioned2023-01-25T10:11:17Z
dc.date.available2023-01-25T10:11:17Z
dc.date.issued2018-06-29
dc.description.abstractThe exact impact of bariatric surgery in metabolically "healthy" (MH) or "unhealthy" (MU) phenotypes for the study of the metabolic improvement is still unknown. We applied an untargeted LC-ESI-TripleTOF-MS-driven metabolomics approach in serum samples from 39 patients with morbid obesity (MH and MU) 1, 3, and 6 months after bariatric surgery. Multiple factor analysis, along with correlation and enrichment analyses, was carried out to distinguish those metabolites associated with metabolic improvement. Hydroxypropionic acids, medium-/long-chain hydroxy fatty acids, and bile acid glucuronides were the most discriminative biomarkers of response between MH and MU phenotypes. Hydroxypropionic (hydroxyphenyllactic-related) acids, amino acids, and glycerolipids were the most significant clusters of metabolites altered after bariatric surgery in MU ( p
dc.identifier.doi10.1021/acs.jproteome.8b00144
dc.identifier.essn1535-3907
dc.identifier.pmid29893570
dc.identifier.unpaywallURLhttp://diposit.ub.edu/dspace/bitstream/2445/162377/1/683368.pdf
dc.identifier.urihttp://hdl.handle.net/10668/12578
dc.issue.number8
dc.journal.titleJournal of proteome research
dc.journal.titleabbreviationJ Proteome Res
dc.language.isoen
dc.organizationHospital Universitario Virgen de la Victoria
dc.organizationInstituto de Investigación Biomédica de Málaga-IBIMA
dc.page.number2704-2714
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.rightsCC0 1.0 Universal
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/
dc.subjectbariatric surgery
dc.subjecthydroxyphenyllactic
dc.subjectindole metabolites
dc.subjectmass spectrometry
dc.subjectmetabolically healthy
dc.subjectmicrobiota metabotype
dc.subjectobesity
dc.subjectuntargeted metabolomics
dc.subject.meshAdult
dc.subject.meshAmino Acids
dc.subject.meshBariatric Surgery
dc.subject.meshBiomarkers
dc.subject.meshFatty Acids
dc.subject.meshFemale
dc.subject.meshHumans
dc.subject.meshLactates
dc.subject.meshLipid Metabolism
dc.subject.meshMale
dc.subject.meshMetabolomics
dc.subject.meshMiddle Aged
dc.subject.meshObesity, Morbid
dc.subject.meshPropionates
dc.titleCharacterization of Metabolomic Profile Associated with Metabolic Improvement after Bariatric Surgery in Subjects with Morbid Obesity.
dc.typeresearch article
dc.type.hasVersionAM
dc.volume.number17
dspace.entity.typePublication

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