Publication: Effectiveness and safety of dual therapy with rilpivirine and boosted darunavir in treatment-experienced patients with advanced HIV infection: a preliminary 24 week analysis (RIDAR study).
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Identifiers
Date
2019-02-28
Authors
Pasquau, Juan
de Jesus, Samantha E
Arazo, Piedad
Crusells, María J
Ríos, María J
Lozano, Fernando
de la Torre, Javier
Galindo, María J
Carmena, Jorge
Santos, Jesús
Advisors
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Abstract
The objective was to analyze the effectiveness and safety of dual therapy with rilpivirine plus boosted-darunavir (RPV + bDRV) in real-life patients. Observational, retrospective, multi-center study in HIV+ patients who had received RPV + bDRV for 24 weeks to optimize/simplify their previous antiretroviral treatment. We determined the percentage of patients without virologic failure (2 consecutive viral loads > 50 copies/mL) at 24 weeks of treatment. The study included 161 patients from 15 hospitals with median age of 49 years; 29.3% had previous AIDS stage and median CD4+ lymphocyte nadir of 170 cells/uL. They had been diagnosed with HIV for a median of 17 years and had received 14 years of ART, with five previous treatment combinations, and 36.6% had a history of virological failure. The reasons for the switch were simplification/optimization (49.7%), toxicity/intolerance (17.4%), or inadequate effectiveness of previous ART (10.6%). Baseline VL of 50-1000 copies/mL was recorded in 25.5% of the patients. In the"intention-to-treat" analysis at 24 weeks, 87.6% of 161 patients continued the study treatment without virologic failure criteria. In the "on treatment" analysis (excluding patients who discontinued treatment with dual therapy for any reason other than virologic failure) the efficacy was 94.6% (141/149 patients). Dual therapy with RPV + DRVb proved to be effective and safe in patients with advanced HIV infection, long exposure to ART, low CD4 nadir, previous virologic failure, and/or history of ineffective ART.
Description
MeSH Terms
Adult
Anti-HIV Agents
CD4-Positive T-Lymphocytes
Darunavir
Drug Therapy, Combination
Female
HIV Infections
Humans
Male
Middle Aged
Retrospective Studies
Rilpivirine
Treatment Outcome
Viral Load
Anti-HIV Agents
CD4-Positive T-Lymphocytes
Darunavir
Drug Therapy, Combination
Female
HIV Infections
Humans
Male
Middle Aged
Retrospective Studies
Rilpivirine
Treatment Outcome
Viral Load
DeCS Terms
CIE Terms
Keywords
Darunavir, Dual therapy, HIV, Nuke-sparing regimens, Rilpivirine, Simplification