Publication: Changes in the total effective xenoestrogen burden (TEXB) of breast cancer patients during an 18-month post-surgical follow-up.
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2017-03-10
Authors
Fernandez, Mariana F
Pumarega, Jose
Porta, Miquel
Molina-Molina, Jose Manuel
Arrebola, Juan P
Olea, Nicolas
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Abstract
We aimed to assess changes in the total effective xenoestrogen burden (TEXB) -a biomarker of combined effect of mixtures of xenoestrogens- in breast cancer patients at surgery (breast adipose tissue) and at different time points during an 18-month follow-up (abdominal adipose tissue), and to analyze the potential influence of socio-demographic, reproductive, tumor, and treatment characteristics on TEXB levels. TEXB-alpha (due to persistent organohalogenated chemicals) and TEXB-beta (due mainly to endogenous estrogens) were quantified in 44 women. TEXB values significantly increased over follow-up (p
Description
MeSH Terms
Adipose Tissue
Adult
Aged
Aged, 80 and over
Body Burden
Breast Neoplasms
Environmental Pollutants
Estrogens
Female
Humans
Hydrocarbons, Chlorinated
Middle Aged
Postoperative Period
Adult
Aged
Aged, 80 and over
Body Burden
Breast Neoplasms
Environmental Pollutants
Estrogens
Female
Humans
Hydrocarbons, Chlorinated
Middle Aged
Postoperative Period
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Keywords
TEXB, breast cancer, cancer treatment, chemotherapy, estrogen receptor tumors, follow up, total effective xenoestrogen burden