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A nutritional intervention study with hydrolyzed collagen in pre-pubertal Spanish children: influence on bone modeling biomarkers

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dc.contributor.authorMartin-Bautista, Elena
dc.contributor.authorMartin-Matillas, Miguel
dc.contributor.authorMartin-Lagos, Jose A.
dc.contributor.authorMiranda-Leon, M\ Teresa
dc.contributor.authorMuñoz-Torres, Manuel
dc.contributor.authorRuiz-Requena, Estrella
dc.contributor.authorRivero, M.
dc.contributor.authorQuer, Josefa
dc.contributor.authorPuigdueta, Isabel
dc.contributor.authorCampoy, Cristina
dc.contributor.authoraffiliation[Martin-Bautista,E; Martin-Matillas,M; Martin-Lagos,JA; Campoy,C] Department of Pediatrics, School of Medicine. University of Granada, Granada, Spain. [Miranda-Leon,MT] Department of Biostatistics, School of Medicine, University of Granada, Granada, Spain. [Munoz-Torres,M] Service of Endocrinology, University Hospital San Cecilio, Granada, Spain. [Ruiz-Requena, E] Service of Biochemistry, University Hospital San Cecilio, Granada, Spain. [Rivero,M; Quer,J; Puigdueta, I]Grupo de Estudios en Nutrición y Alimentación-GENA, Barcelona, Spain.es
dc.date.accessioned2014-02-03T10:16:03Z
dc.date.available2014-02-03T10:16:03Z
dc.date.issued2011-04
dc.descriptionJournal Article; Randomized Controlled Trial.es
dc.description.abstractAim: The aim of the study was to investigate the influence of dietary intake of commercial hydrolyzed collagen (Gelatine Royal ®) on bone remodeling in pre-pubertal children. Methods: A randomized double-blind study was carried out in 60 children (9.42 ± 1.31 years) divided into three groups according to the amount of partially hydrolyzed collagen taken daily for 4 months: placebo (G-I, n = 18), collagen (G-II, n = 20) and collagen + calcium (G-III, n = 22) groups. Analyses of the following biochemical markers were carried out: total and bone alkaline phosphatase (tALP and bALP), osteocalcin, tartrate-resistant acid phosphatase (TRAP), type I collagen carboxy terminal telopeptide, lipids, calcium, 25-hydroxyvitamin D, insulin-like growth factor 1 (IGF-1), thyroid-stimulating hormone, free thyroxin and intact parathormone. Results: There was a significantly greater increase in serum IGF-1 in G-III than in G II (p < 0.01) or G-I (p < 0.05) during the study period, and a significantly greater increase in plasma tALP in G-III than in G-I (p < 0.05). Serum bALP behavior significantly (p < 0.05) differed between G-II (increase) and G-I (decrease). Plasma TRAP behavior significantly differed between G-II and G-I (p < 0.01) and between G-III and G-II (p < 0.05). Conclusion: Daily dietary intake of hydrolyzed collagen seems to have a potential role in enhancing bone remodeling at key stages of growth and development.es
dc.description.versionYeses
dc.identifier.citationMartin-Bautista E, Martin-Matillas M, Martin-Lagos JA, Miranda-Leon MT, Muñoz-Torres M, Ruiz-Requena E, et al. A nutritional intervention study with hydrolyzed collagen in pre-pubertal spanish children: influence on bone modeling biomarkers. J. Pediatr. Endocrinol. Metab. 2011; 24(3-4):147-53es
dc.identifier.doi10.1515/JPEM.2011.009
dc.identifier.essn2191-0251
dc.identifier.issn0334-018X
dc.identifier.pmid21648282
dc.identifier.urihttp://hdl.handle.net/10668/1484
dc.journal.titleJournal of pediatric endocrinology & metabolism : JPEM
dc.language.isoen
dc.publisherWalter de Gruyteres
dc.relation.publisherversionhttp://www.degruyter.com/view/j/jpem.2011.24.issue-3-4/jpem.2011.009/jpem.2011.009.xmles
dc.rights.accessRightsopen access
dc.subjectBonees
dc.subjectChildrenes
dc.subjectProteines
dc.subjectProteínas en la Dietaes
dc.subjectColágeno Tipo Ies
dc.subjectMarcadores Biológicoses
dc.subjectFosfatasa Alcalinaes
dc.subjectNiñoes
dc.subjectRemodelación Óseaes
dc.subjectProteínas en la Dietaes
dc.subjectPruebas de Química Clínicaes
dc.subjectFuerza de la Manoes
dc.subjectDietaes
dc.subjectHidrólisises
dc.subjectFemeninoes
dc.subjectMasculinoes
dc.subjectHumanoes
dc.subjectEspañaes
dc.subjectPubertades
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Biological Factors::Biological Markerses
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Musculoskeletal and Neural Physiological Phenomena::Musculoskeletal Physiological Phenomena::Musculoskeletal Physiological Processes::Bone Remodelinges
dc.subject.meshMedical Subject Headings::Named Groups::Persons::Age Groups::Childes
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Clinical Laboratory Techniques::Clinical Chemistry Testses
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Macromolecular Substances::Polymers::Biopolymers::Collagen::Fibrillar Collagens::Collagen Type Ies
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Physiological Phenomena::Nutritional Physiological Phenomena::Dietes
dc.subject.meshMedical Subject Headings::Technology, Industry, Agriculture::Food and Beverages::Food::Dietary Proteinses
dc.subject.meshMedical Subject Headings::Check Tags::Femalees
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Diagnostic Techniques and Procedures::Physical Examination::Muscle Strength::Hand Strengthes
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Chemical Phenomena::Chemical Processes::Hydrolysises
dc.subject.meshMedical Subject Headings::Check Tags::Malees
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Pubertyes
dc.subject.meshMedical Subject Headings::Geographicals::Geographic Locations::Europe::Spaines
dc.subject.meshMedical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Esterases::Phosphoric Monoester Hydrolases::Alkaline Phosphatasees
dc.titleA nutritional intervention study with hydrolyzed collagen in pre-pubertal Spanish children: influence on bone modeling biomarkerses
dc.typeresearch article
dc.type.hasVersionVoR
dspace.entity.typePublication

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