Publication:
Spatiotemporal Characteristics of the Largest HIV-1 CRF02_AG Outbreak in Spain: Evidence for Onward Transmissions.

Simple item page
dc.contributor.authorKostaki, Evangelia-Georgia
dc.contributor.authorFlampouris, Andreas
dc.contributor.authorKaramitros, Timokratis
dc.contributor.authorChueca, Natalia
dc.contributor.authorAlvarez, Marta
dc.contributor.authorCasas, Paz
dc.contributor.authorAlejos, Belen
dc.contributor.authorHatzakis, Angelos
dc.contributor.authorGarcia, Federico
dc.contributor.authorParaskevis, Dimitrios
dc.contributor.authorCoRIS
dc.date.accessioned2023-01-25T13:32:21Z
dc.date.available2023-01-25T13:32:21Z
dc.date.issued2019-03-11
dc.description.abstractBackground and Aim: The circulating recombinant form 02_AG (CRF02_AG) is the predominant clade among the human immunodeficiency virus type-1 (HIV-1) non-Bs with a prevalence of 5.97% (95% Confidence Interval-CI: 5.41-6.57%) across Spain. Our aim was to estimate the levels of regional clustering for CRF02_AG and the spatiotemporal characteristics of the largest CRF02_AG subepidemic in Spain. Methods: We studied 396 CRF02_AG sequences obtained from HIV-1 diagnosed patients during 2000-2014 from 10 autonomous communities of Spain. Phylogenetic analysis was performed on the 391 CRF02_AG sequences along with all globally sampled CRF02_AG sequences (N = 3,302) as references. Phylodynamic and phylogeographic analysis was performed to the largest CRF02_AG monophyletic cluster by a Bayesian method in BEAST v1.8.0 and by reconstructing ancestral states using the criterion of parsimony in Mesquite v3.4, respectively. Results: The HIV-1 CRF02_AG prevalence differed across Spanish autonomous communities we sampled from (p
dc.identifier.doi10.3389/fmicb.2019.00370
dc.identifier.issn1664-302X
dc.identifier.pmcPMC6421502
dc.identifier.pmid30915040
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6421502/pdf
dc.identifier.unpaywallURLhttps://www.frontiersin.org/articles/10.3389/fmicb.2019.00370/pdf
dc.identifier.urihttp://hdl.handle.net/10668/13760
dc.journal.titleFrontiers in microbiology
dc.journal.titleabbreviationFront Microbiol
dc.language.isoen
dc.organizationHospital Universitario San Cecilio
dc.organizationHospital Universitario San Cecilio
dc.organizationHospital Universitario de Jaén
dc.organizationHospital Universitario Virgen de la Victoria
dc.organizationHospital Costa del Sol
dc.organizationHospital Costa del Sol
dc.organizationÁrea de Gestión Sanitaria Sur de Sevilla
dc.organizationHospital Universitario Virgen del Rocío
dc.organizationAGS - Sur de Sevilla
dc.page.number370
dc.pubmedtypeJournal Article
dc.rightsAttribution 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectCRF02_AG
dc.subjectHIV-1
dc.subjectSpain
dc.subjectregional dispersal
dc.subjectspatiotemporal characteristics
dc.titleSpatiotemporal Characteristics of the Largest HIV-1 CRF02_AG Outbreak in Spain: Evidence for Onward Transmissions.
dc.typeresearch article
dc.type.hasVersionVoR
dc.volume.number10
dspace.entity.typePublication

Files

Original bundle

Now showing 1 - 1 of 1
Thumbnail Image
Name:
PMC6421502.pdf
Size:
2.92 MB
Format:
Adobe Portable Document Format
Download

Collections

SAS - Hospital Universitario San Cecilio
SAS - Hospital Costa del Sol
SAS - Hospital Universitario de Jaén
SAS - Hospital Universitario Virgen de la Victoria
SAS - Hospital Universitario Virgen de Valme
SAS - Hospital Universitario Virgen del Rocío

© 2023 – Repositorio Institucional de Salud de Andalucía - Fundación Pública Andaluza Progreso y Salud - Consejería de Salud y Consumo de la Junta de Andalucía