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Chromosome and abnormalities are associated with an even worse outcome and karyotype complexity in patiens with chronic lymphocytic leukemia and TP53 A

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dc.contributor.authorBlanco, A
dc.contributor.authorPuiggros, A
dc.contributor.authorBaliakas, P
dc.contributor.authorAthanasiadou, A
dc.contributor.authorGarcía-Malo, MD
dc.contributor.authorCollado, R
dc.contributor.authorXochelli, A
dc.contributor.authorRodríguez-Rivera, M
dc.contributor.authorOrtega, M
dc.contributor.authorCalasanz, MJ
dc.contributor.authorLuño, E
dc.contributor.authorVargas, MT
dc.contributor.authorGrau, J
dc.contributor.authorMartínez-Laperche, C
dc.contributor.authorValiente, A
dc.contributor.authorPapaioannou, G
dc.contributor.authorCervera, J
dc.contributor.authorAnagnostopoulos, A
dc.contributor.authorPiñán, MA
dc.contributor.authorStalika, E
dc.contributor.authorHernández-Rivas, JM
dc.contributor.authorBatlle, A
dc.contributor.authorSalido, M
dc.contributor.authorOrtuño, F
dc.contributor.authorMelero, c
dc.contributor.authorRobles, D
dc.contributor.authorFerrer, A
dc.contributor.authorIvars, D
dc.contributor.authorRodríguez, A
dc.contributor.authorGonzález, M
dc.contributor.authorBosch, F
dc.contributor.authorAbrisqueta, P
dc.contributor.authorStamatopoulos, K
dc.contributor.authorEspinet, B
dc.contributor.authoraffiliation[Blanco,A; Puiggros,A; Rodríguez-Rivera,M; Salido,M; Melero,C; Ferrer,A; Espinet,B] Laboratori de Citogenètica Molecular, Laboratori de Citologia Hematològica, Servei de Patologia, Hospital del Mar/Grup de Recerca Translacional en Neoplàsies Hematològiques, Institut Hospital del Mar d’Investigacions Mèdiques(IMIM), Barcelona, Spain. [Baliakas,P] Department of Immunology, Genetics and Pathology, Science for Life Laboratory, Uppsala University, Uppsala, Sweden. [Athanasiadou,A; Papaioannou,G; Anagnostopoulos,A] Hematology Department and HCT Unit, G. Papanicolaou Hospital, Thessaloniki, Greece. [García-Malo,MD; Ortuño,F] Servicio de Hematología, Hospital Universitario Morales Meseguer, Murcia, Spain. [Collado,R; Ivars,D] Servicio de Hematología, Consorcio Hospital General Universitario, Valencia, Spain. [Xochelli,A; Stalika,E] Institute of Applied Biosciences, CERTH, Thessaloniki, Greece. [Ortega,M; Bosch,F; Abrisqueta,P] Laboratorio de Citogenética y Servicio de Hematología, Hospital Vall d’Hebron, Barcelona, Spain. [Calasanz,MJ] Servicio de Citogenética, Departamento de Genética, Universidad de Navarra, Pamplona, Spain. [Luño,E] Servicio de Hematología, Hospital Universitario Central de Asturias, Oviedo, Spain. [Vargas,MT; Rodríguez,A] Hospital Universitario Virgen de la Macarena, Sevilla, Spain. [Grau,J] Servei Laboratori Hematologia, ICO-Hospital Germans Trias i Pujol, Institut de Recerca Contra la Leucèmia Josep Carreras (IJC), Universitat Autònoma de Barcelona, Badalona, Spain. [Martínez-Laperche,C] Laboratorio de Genética Hematológica, Servicio de Hematología. Hosp. G.U. Gregorio Marañón, Madrid. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain. [Valiente,A] Servicios de Genética y Hematología, Complejo Hospitalario de Navarra, Pamplona, Spain. [Cervera,J] Unidad de Genética, Hospital Universitario La Fe, Valencia, Spain. [Piñán,MA] Servicio de Hematología, Hospital de Cruces, Bilbao, Spain. [Hernández-Rivas,MJ] Servicio de Hematología, Hospital Universitario de Salamanca, IBSAL, IBMCC, Centro de Investigación del Cáncer, Universidad de Salamanca, CSIC, Salamanca, Spain. [Batlle,A] Servicio de Hematología, Hospital Universitario Marqués de Valdecilla, Santander, Spain. [Robles,D] Servicio de Hematología, Hospital Txagorritxu, Vitoria, Spain. [Stamatopoulos,K] Hematology Department and HCT Unit, G. Papanicolaou Hospital/Institute of Applied Biosciences, CERTH, Thessaloniki, Greece.es
dc.date.accessioned2016-11-23T12:11:34Z
dc.date.available2016-11-23T12:11:34Z
dc.date.issued2016-06-09
dc.description.abstractTP53 aberrations (deletions and/or mutations, TP53ab) in chronic lymphocytic leukemia (CLL) are associated with dismal clinical outcome and reduced life expectancy. However, mounting evidence suggests that within cases carrying TP53ab other cytogenetic features may also influence the clinical outcome. Alterations in chromosome 8, in particular 8p losses (affecting several regions, from 8p12 to 8p23) and 8q gains (usually involving 8q24, where MYC is located), are enriched in TP53ab patients and have been proposed as features with potential prognostic value within this aggressive group.es
dc.description.versionYeses
dc.identifier.citationBlanco G, Puiggros A, Baliakas P, Athanasiadou A, García-Malo MD, Collado R, el al. Chromosome and abnormalities are associated with an even worse outcome and karyotype complexity in patiens with chronic lymphocytic leukemia and TP53 A. HAEMATOLOGICA. 2016, Vol. 101, (S1) pp. 229-230es
dc.identifier.essn1592-8721
dc.identifier.issn0390-6078
dc.identifier.urihttp://hdl.handle.net/10668/2539
dc.journal.titleHaematologica
dc.language.isoen
dc.publisherFerrata Storti Foundationes
dc.relation.publisherversionhttp://www.haematologica.org/content/101/s1es
dc.rights.accessRightsopen access
dc.subjectCromosomas humanos par 8es
dc.subjectCitogenéticaes
dc.subjectLeucemia linfoidees
dc.subjectEsperanza de vidaes
dc.subjectEliminación de secuenciaes
dc.subject.meshMedical Subject Headings::Anatomy::Cells::Cellular Structures::Chromosomes::Chromosomes, Mammalian::Chromosomes, Human::Chromosomes, Human, 6-12 and X::Chromosomes, Human, Pair 8es
dc.subject.meshMedical Subject Headings::Disciplines and Occupations::Natural Science Disciplines::Biological Science Disciplines::Biology::Genetics::Cytogeneticses
dc.subject.meshMedical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humanses
dc.subject.meshMedical Subject Headings::Diseases::Neoplasms::Neoplasms by Histologic Type::Leukemia::Leukemia, Lymphoides
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Life Expectancyes
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Mutationes
dc.subject.meshMedical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity::Prevalencees
dc.subject.meshMedical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Processes::Mutagenesis::Sequence Deletiones
dc.titleChromosome and abnormalities are associated with an even worse outcome and karyotype complexity in patiens with chronic lymphocytic leukemia and TP53 Aes
dc.typeconference presentation
dc.type.hasVersionVoR
dspace.entity.typePublication

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