Publication:
Mitochondrial Homeostasis in Obesity-related Hypertriglyceridemia.

dc.contributor.authorMela, Virginia
dc.contributor.authorRuiz-Limón, Patricia
dc.contributor.authorBalongo, Manuel
dc.contributor.authorMotahari Rad, Hanieh
dc.contributor.authorSubiri-Verdugo, Alba
dc.contributor.authorGonzalez-Jimenez, Andres
dc.contributor.authorSoler, Rocio
dc.contributor.authorOcaña, Luis
dc.contributor.authorEl Azzouzi, Hamid
dc.contributor.authorTinahones, Francisco J
dc.contributor.authorValdivielso, Pedro
dc.contributor.authorMurri, Mora
dc.date.accessioned2023-05-03T13:35:48Z
dc.date.available2023-05-03T13:35:48Z
dc.date.issued2022
dc.description.abstractThe prevalence of obesity and hypertriglyceridemia is an alarming worldwide health issue. Mitochondria play a central role in these disorders as they control cell metabolism. The aim of the present study was to characterize mitochondrial homeostasis in subcutaneous and visceral adipose tissue (SAT and VAT) in grade III obese patients with and without hypertriglyceridemia. Moreover, this study presents the evaluation of mitochondrial fitness as a marker for hypertriglyceridemia improvement. Eight control and 12 hypertriglyceridemic (HTG) grade III obese subjects undergoing bariatric surgery were included. Anthropometric and biochemical data were obtained before and 3 months after surgery. Mitochondrial homeostasis was evaluated by mitochondrial DNA (mtDNA), gene expression and protein abundance in SAT and VAT. Mitophagy-related gene expression was increased in HTG SAT and VAT, while mitochondrial marker gene expression and mtDNA were decreased, indicating an altered mitochondrial homeostasis in HTG. Mitophagy protein abundance was increased in VAT of those subjects that did not improve their levels of triglycerides after bariatric surgery, whereas mitochondrial protein was decreased in the same tissue. Indeed, triglyceride levels positively correlated with mitophagy-related genes and negatively with mitochondrial content markers. Moreover, mitochondria content and mitophagy markers seem to be significant predictors of hypertriglyceridemia and hypertriglyceridemia remission. Mitochondrial homeostasis of adipose tissue is altered in hypertriglyceridemic patients. At the protein level, mitochondria content and mitophagy are potential markers of hypertriglyceridemia remission in obese patients after bariatric surgery. These results may contribute to the implementation of a clinical approach for personalized medicine.
dc.identifier.doi10.1210/clinem/dgac332
dc.identifier.essn1945-7197
dc.identifier.pmcPMC9282366
dc.identifier.pmid35608825
dc.identifier.pubmedURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9282366/pdf
dc.identifier.unpaywallURLhttps://doi.org/10.1210/clinem/dgac332
dc.identifier.urihttp://hdl.handle.net/10668/20395
dc.issue.number8
dc.journal.titleThe Journal of clinical endocrinology and metabolism
dc.journal.titleabbreviationJ Clin Endocrinol Metab
dc.language.isoen
dc.organizationHospital Universitario Virgen de la Victoria
dc.organizationHospital Universitario Virgen de la Victoria
dc.organizationInstituto de Investigación Biomédica de Málaga-IBIMA
dc.page.number2203-2215
dc.pubmedtypeJournal Article
dc.pubmedtypeResearch Support, Non-U.S. Gov't
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.accessRightsopen access
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjecthypertriglyceridemia
dc.subjectmetabolism
dc.subjectmitochondrial fitness
dc.subjectmitophagy
dc.subjectobesity
dc.subject.meshBiomarkers
dc.subject.meshDNA, Mitochondrial
dc.subject.meshHomeostasis
dc.subject.meshHumans
dc.subject.meshHypertriglyceridemia
dc.subject.meshIntra-Abdominal Fat
dc.subject.meshMitochondria
dc.subject.meshObesity
dc.subject.meshSubcutaneous Fat
dc.titleMitochondrial Homeostasis in Obesity-related Hypertriglyceridemia.
dc.typeresearch article
dc.type.hasVersionAM
dc.volume.number107
dspace.entity.typePublication

Files